The truncated C-terminal portion of Bid (tBid) is an important intermedi-ate in ligand-induced apoptosis. tBid has been shown to be sensitive to pro-teasomal inhibitors and downregulated by activation of the epidermal
growth factor (EGF) pathway. Here, we provide evidence that tBid is a
substrate of the ubiquitin ligase Itch, which can specifically interact with
and ubiquitinate tBid, but not intact Bid.
A series of chimeric receptors was generated between the epidermal growth factor (EGF) receptor, ErbB-1, and its homologue, ErbB-4, to investigate the roles of the extracellular domains (I–IV) in the ligand speciﬁcities. As compared with ErbB-1 and the chimeras with both domains I and III of ErbB-1, the chimeras with only one of these domains exhibited reduced binding of 125I-labeled EGF. Particularly, the contribution of domain III was appreciably larger than that of domain I of ErbB-1 in 125I-labeled EGF binding.
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:Tumor necrosis factor alpha and epidermal growth factor act additively to inhibit matrix gene expression by chondrocyte...
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: " The epidermal growth factor receptor (EGFR) in head and neck cancer: its role and treatment implications...
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Platelet-derived growth factor receptor-b and epidermal growth factor receptor in pulmonary vasculature of systemic sclerosis-associated pulmonary arterial hypertension versus idiopathic pulmonary arterial hypertension and pulmonary veno-occlusive disease: a case-control study...
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:"Role of epidermal growth factor receptor activation in regulating mucin synthesis...
Abstract Epidermal growth factor receptor (EGFR) kinase domain mutations hyperactivate the kinase and confer kinase addiction of the non-small-cell lung cancer (NSCLC) tumor cells. Almost all of these mutations are located within exons 18-21. The -216 single nucleotide polymorphism in the promoter region is associated with increased EGFR production. We present a method for detecting these common mutations in 81 cases of NSCLC.
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Wildtype epidermal growth factor receptor (Egfr) is not required for daily locomotor or masking behavior in mice...
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Sustained complete remission of human epidermal growth factor receptor 2-positive metastatic breast cancer in the liver during long-term trastuzumab (Herceptin) maintenance therapy in a woman: a case report
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Safety, immunogenicity and preliminary efficacy of multiple-site vaccination with an Epidermal Growth Factor (EGF) based cancer vaccine in advanced non small cell lung cancer (NSCLC) patients...
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Proinflammatory role of amphiregulin, an epidermal growth factor family member whose expression is augmented in rheumatoid arthritis patients...
Epidermal growth factor receptor (EGFR) and its three related proteins
(the ERBB family) are receptor tyrosine kinases that play essential roles in
both normal physiological conditions and cancerous conditions. Upon
binding its ligands, dynamic conformational changes occur in both extra-
The discovery that signaling by the epidermal growth factor receptor
(EGFR) plays a key role in tumorigenesis prompted efforts to target this
receptor in anticancer therapy. Two different types of EGFR-targeted ther-apeutic agents were subsequently developed: mAbs, such as cetuximab and
panitumumab, which target the extracellular domain of the receptor,
A common physiological response of organisms to environmental stresses
is the increase in expression of heat shock proteins (Hsps). In insects, this
process has been widely examined for heat stress, but the response to cold
stress has been far less studied.
Both the epidermal growth factor receptor signaling pathway and micro-RNA (miRNA) play an important role in lung cancer development and
progression. To address the potential role of miRNA in epidermal growth
factor receptor signaling, we identified miR-125a-5p as a downstream
target, using an miRNA array.
Controlled activation of epidermal growth factor receptor (EGFR) is sys-tematically guaranteed at the molecular level; however, aberrant activation
of EGFR is frequently found in cancer. Transcription induced by EGFR
activation often involves the coordinated expression of genes that positively
and negatively regulate the original signaling pathway; therefore, altera-tions in EGFR kinase activity may reflect changes in gene expression asso-ciated with the pathway.
The mechanism behind the growth-promoting effect of insulin is a subject
of debate. Employing RT4 bladder cancer cells, we examined the cross-talk
between insulin and the epidermal growth factor system. We found that
insulin induced a time- and dose-dependent (25–1000 nmolÆL
increase in mRNA expression of three ligands from the epidermal growth
We investigated the survival signals of epidermal growth factor (EGF) in
human gastric adenocarcinoma cell line TMK-1. Treatment of TMK-1 cells
with adriamycin (ADR) caused apoptosis and apoptosis-related reactions
such as the release of cytochromecfrom mitochondria and the activation
of caspase 9.
Gangliosideshavebeen found toreside inglycosphingolipid-enriched microdomains (GEM) of the plasma membrane
and to be involved in the regulation of epidermal growth
factor receptor (EGFr or ErbB1) activity.To gain further
insight into the mechanisms involved in EGFr modulation
by gangliosides, we investigated the distribution of EGFr
family members in the plasma membrane of CHO-K1 cells,
which were genetically modified to express different gan-glioside molecules or depleted of glycolipids.