Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:CD7 in acute myeloid leukemia: correlation with loss of wild-type CEBPA, consequence of epigenetic regulation
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Epigenetic regulation: DNA confers identity but is not enough to maintain it...
For decades, endocytosis has been recognized as a fundamental cellular process that
regulates the uptake of small molecules (cell surface proteins, bacteria, toxins, etc.) into
the cell. So why, after years of study, does this simple process warrant more
discussion? Anyone who has examined the endocytic pathway will appreciate that this
conceptually simple mechanism is highly complex and sophisticated. Like ballet
dancers who make their synchronous performance seem effortless, the cell brings in
molecules via a carefully choreographed mechanism.
MicroRNAs (miRNAs) comprise species of short noncoding RNA that
regulate gene expression post-transcriptionally. Recent studies have demon-strated that epigenetic mechanisms, including DNA methylation and his-tone modification, not only regulate the expression of protein-encoding
genes, but also miRNAs, such as let-7a, miR-9, miR-34a, miR-124, miR-137, miR-148 and miR-203.
Chapter 16 - Gene regulation in eukaryotes. The main contents of this chapter include all of the following: Overview of eukaryotic gene regulation, control of transcription initiation, chromatin structure and epigenetic effects, regulation after transcription, a comprehensive example: sex determination in Drosophila.
MicroRNAs (miRNAs) are involved in a plethora of important biological
processes, from embryonic development to homeostasis in adult tissues.
Recently, miRNAs have emerged as a class of epigenetic regulators of
metabolism and energy homeostasis.
(BQ) Part 1 book "Epigenetics and dermatology" presents the following contents: Introduction to epigenetics, laboratory methods in epigenetics, epigenetics and fibrosis, epigenetic modulation of hair follicle stem cells, epigenetics and the regulation of inflammation,...
There is growing evidence on the importance of studies focusing on mechanisms and
strategies leading to cancer prevention. The plethora of approaches include regulation
of oxidative stress using antioxidant therapies, carefully balanced diets and living
habits, epidemiological evidence and molecular approaches on the role of key
biological molecules such as antioxidant enzymes, vitamins, proteins and naturally
occurring free radical scavengers as well as controversial results and clinical
applications. These are some of the topics that this book highlights.
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Advances in the genetics and epigenetics of gene regulation and human disease...
Histone acetylation plays an integral role in the epigenetic regulation of
gene expression. Transcriptional activity reflects the recruitment of oppo-sing classes of enzymes to promoter elements; histone acetyltransferases
(EC 22.214.171.124) that deposit acetyl marks at a subset of histone residues and
histone deacetylases that remove them.
The folding of eukaryotic DNA into the 30 nm fibre comprises the first
level of transcriptionally dormant chromatin. Understanding its structure
and the processes of its folding and unfolding is a prerequisite for under-standing the epigenetic regulation in cell differentiation.
During the development of multicellular organisms, both transient and stable gene expression patterns have to be established in a precisely orchestrated sequence. Evidence from diverse model organisms indicates that this epigenetic program involves not only transcription factors, but also the local structure, composition, and modiﬁcation of chromatin, which deﬁne and maintain the accessibility and transcriptional competence of the nucleosomal DNA template.
After recent accounting scandals in once high-flying firms like Enron and WorldCom, man-
agement behavior has been under close scrutiny by regulators, financial media, and researchers.
Jensen (2005) argues that the dramatic increase in corporate scandals around the turn of the cen-
tury can be explained by agency costs of overvalued equity: when a firm’s equity is substantially
overvalued, managers are forced to take value-destroying actions (some perhaps fraudulent) to
satisfy the market’s unrealistic growth expectations.
The transcription factor ZBP-89 has been implicated in the induction of
growth arrest and apoptosis. In this article, we demonstrate that ZBP-89
was able to restrain senescence in NCI-H460 human lung cancer cells,
through epigenetically regulating p16
Epigenetics refers to heritable phenotypic alterations in the absence of
DNA sequence changes, and DNA methylation is one of the extensively
studied epigenetic alterations. DNA methylation is an evolutionally con-served mechanism to regulate gene expression in mammals.
Cancer may constitute the most extensively studied
disease entity of our time. Nevertheless, our comprehension
of the cellular and molecular pathology
of malignant transformation is incomplete. In view
of the diverse clinical presentations of various
malignancies, doubts may be raised as to whether it
is appropriate to refer to cancer as one group of disease
states. The notion of malignant tumors as a
pathologic and pathophysiologic class of conditions
begs the question for defining criteria that characterize
all malignant growths, regardless of their tissue
With complaints and inquiries from senior citizen investors concerning financial services and
investment fraud increasing, the Missouri Securities Division, a division in the Office of Missouri
Secretary of State Robin Carnahan,
took steps to determine how to best increase protection
for those investors.
Does this mean that differences in genetic diversity levels will have predictable
ecological consequences? The answer is no, because only one portion of genetic diversity is
connected to ecological factors, i.e. adaptation. Ecological adaptation is a significant factor
for example, in range expansion of plant species. Plants with different genotypes conferring
the highest levels of fitness are expected to survive and reproduce better, shifting the gene
pool over time towards higher frequencies of the alleles making up the more successful
genotypes (Ward et al., 2008).
Remaining Funds, which account for €147 billion of shares/units in issue, consist primarily
of mixed funds, but also include real estate and other unclassified funds. This category has
performed positively in Q1 2012, second only to equity funds in terms of revaluations, with
asset growth of €8.9 billion or 6.4 per cent. Remaining funds were the strongest performing
category in Q4 2011, and despite a continued resilient performance, the category attracted
negligible net new investment of €0.1 billion.