Calcified plaque in the coronary arteries is a marker for atheromatous-plaque burden
and is predictive of future risk of cardiovascular events. We examined the relationship
between estrogen therapy and coronary-artery calcium in the context of a randomized
In our ancillary substudy of the Women’s Health Initiative trial of conjugated equine
estrogens (0.625 mg per day) as compared with placebo in women who had undergone
hysterectomy, we performed computed tomography of the heart in 1064 women
aged 50 to 59 years at randomization.
THỬ NGHIỆM HOẠT TÍNH ESTROGEN CỦA MẦM HẠT ĐẬU NÀNH
TÓM TẮT Mục tiêu: Hạt Đậu nành (Glycine max) là nguồn nguyên liệu chứa nhiều genistein, đây là một loại isoflavonoid có hoạt tính estrogen, được dùng như một liệu pháp hormon thay thế HRT (hormone replacement therapy). Những thử nghiệm dược lý đã chứng minh các flavonoid trong mầm hạt Đậu nành có thể hỗ trợ cho các trường hợp thiểu năng estradiol trên chuột thí nghiệm.
The hippocampus and cerebral cortex are areas associated with
seizure initiation and propagation. It is therefore discussed how pathological disturbances
in the local estrogen production after menopause may contribute to an increase in seizures
in some women (Veliskova, 2007).
Estrone is the primary estrogen after menopause, and its main source is subcutaneous fat.
This might be of importance for overweight women with epilepsy. Little is known on the
influence of estrone on epilepsy.
Estrogen therapy: Using estrogen to treat symptoms of change of life is known as
estrogen therapy or menopausal hormone therapy. Estrogen treatment can reduce hot
flashes, improve vaginal dryness, and help prevent the weakening of the bones
(osteoporosis) that can happen with menopause. But the use of estrogen by itself
increases a woman's risk of getting endometrial cancer in women who still have a uterus.
Estrogen therapy also increases a woman's chance of developing serious blood clots and
Endocrine Therapy Normal breast tissue is estrogen-dependent. Both primary and metastatic breast cancer may retain this phenotype. The best means of ascertaining whether a breast cancer is hormone-dependent is through analysis of estrogen and progesterone receptor levels on the tumor. Tumors that are positive for the estrogen receptor and negative for the progesterone receptor have a response rate of ~30%. Tumors that have both receptors have a response rate approaching 70%. If neither receptor is present, the objective response rates are ...
Chemoprevention of Breast Cancer Hormonal manipulation is being tested in the primary prevention of breast cancer. Tamoxifen is an antiestrogen with partial estrogen agonistic activity in some tissues, such as endometrium and bone. One of its actions is to upregulate transforming growth factor β, which decreases breast cell proliferation. In randomized placebo-controlled trials to assess tamoxifen as adjuvant therapy for breast cancer, tamoxifen reduced the number of new breast cancers in the opposite breast by more than a third.
• Menopausal hormone therapy: Some studies have
suggested that women who take estrogen by itself
(estrogen without progesterone) for 10 or more
years may have an increased risk of ovarian cancer.
Scientists have also studied whether taking certain
fertility drugs, using talcum powder, or being obese are
risk factors. It is not clear whether these are risk
factors, but if they are, they are not strong risk factors.
Having a risk factor does not mean that a woman
will get ovarian cancer. Most women who have risk
factors do not get ovarian cancer.
Do the cancer cells have
Hormone receptors are like ears on and
in breast cells that listen to signals from
hormones. These hormone signals tell
breast cells that have the receptors to
A cancer is called eR-positive if it has
receptors for the hormone estrogen. It’s
called PR-positive if it has receptors for
the hormone progesterone. Breast cells
that do not have receptors are negative
for these hormones.
Breast cancers that are ER-positive,
PR-positive, or both tend to respond to