Complex Genetic Disorders
The expression of many common diseases such as cardiovascular disease, hypertension, diabetes, asthma, psychiatric disorders, and certain cancers is determined by a combination of genetic background, environmental factors, and lifestyle. A trait is called polygenic if multiple genes contribute to the phenotype or multifactorial if multiple genes are assumed to interact with environmental factors. Genetic models for these complex traits need to account for genetic heterogeneity and interactions with other genes and the environment.
Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học quốc tế đề tài: Genetic heterogeneity of residual variance estimation of variance components using double hierarchical generalized linear models
The epidemiology of infectious diseases is one of the great triumphs of applied
ecology. In particular, the public health importance of parasites has
lead to a large literature, exploring their impact on the population dynamics,
population genetics and evolutionary biology of human populations. An
important milestone was the Dahlem Conference on population biology of infectious
diseases, held in 1981. The resulting book (Anderson and May 1982)
lucidly summarised the contemporary state of parasite ecology and epidemiology.
Many disorders exhibit the feature of locus heterogeneity, which refers to the fact that mutations in different genes can cause phenotypically similar disorders. For example, osteogenesis imperfecta (Chap. 357), long QT syndrome (Chap. 226), muscular dystrophy (Chap. 382), homocystinuria (Chap. 358), retinitis pigmentosa (Chap. 29), and hereditary predisposition to colon cancer (Chap. 87) or breast cancer (Chap. 86) can each be caused by mutations in distinct genes.
Phenotypic heterogeneity occurs when more than one phenotype is caused by allelic mutations (e.g., different mutations in the same gene) (Table 62-4). For example, laminopathies are monogenic multisystem disorders that result from mutations in the LMNA gene, which encodes the nuclear lamins A and C. Twelve autosomal dominant and four autosomal recessive disorders are caused by mutations in the LMNA gene.
The heterogeneous nuclear ribonucleoprotein (hnRNP) type I, a modulator of alternative splicing, localizes in the nucleoplasm of mammalian cells and in a discrete perinucleolar structure. HnRNP I contains a novel type of bipartite nuclear localization signal (NLS) at the N-terminus of the protein that we have previously named nuclear determinant localization type I (NLD-I). Recently, a neural counterpart of hnRNP I has been identiﬁed that contains a putative NLS with two strings of basic amino acids separated by a spacer of 30 residues....
Gaps in knowledge were detected in the
course of this review. These are summarized
in the following section, which also
suggests directions for further investigation.
Further study and regular dietary
monitoring are needed in order to know
more about food consumption habits in
seniors. These investigations must be
adapted to the reality of targeted aging
populations using precise measurements,
diverse approaches, appropriate methods
and accurate dietary assessment tools to
reflect the great heterogeneity typical of
While the ECB’s policy response has, to a signiﬁ cant extent, sheltered the non-ﬁ nancial private
sector from the sovereign debt crisis, and has avoided major disruptions in the ﬁ nancing of the
economy, the ﬁ nancing environment of both banks and the non-ﬁ nancial private sector of countries
affected by the sovereign debt crisis remains challenging.
The realisation of such a marketing strategy requires not only the existence of a he t-
erogeneous consumer goods market, but also the possibility to identify market seg-
ments which are internally homogeneous and externally heterogeneous with regard to
the product related needs and wants of their members.
Abstract—Efficient event delivery in a content-based
publish/subscribe system has been a challenging problem.
Existing group communication solutions, such as IP multicast or
application-level multicast techniques, are not readily applicable
due to the highly heterogeneous communication pattern in such
systems. We first explore the design space of event routing
strategies for content-based publish/subscribe systems.
Tuyển tập các báo cáo nghiên cứu về lâm nghiệp được đăng trên tạp chí lâm nghiệp Original article đề tài: Across-site heterogeneity of genetic and environmental variances in the genetic evaluation of Eucalyptus globulus trials for height growth...
Tuyển tập các báo cáo nghiên cứu về lâm nghiệp được đăng trên tạp chí lâm nghiệp Original article đề tài: "Across-site heterogeneity of genetic and environmental variances in the genetic evaluation of Eucalyptus globulus trials for height growth"
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Genetics of childhood and adolescent depression: insights into etiological heterogeneity and challenges for future genomic research
Tuyển tập các báo cáo nghiên cứu về lâm nghiệp được đăng trên tạp chí lâm nghiệp Original article đề tài: Genetic variation of Prunus avium in susceptibility to cherry leaf spot (Blumeriella jaapii) in spatially heterogeneous infected seed orchards...
Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Expected efficiency of selection for growth
in a French beef cattle breeding scheme. II. Prediction of asymptotic genetic gain in a heterogeneous population
Uterine myomas are the most common benign tumors in women, affecting
20%–50% of reproductive age population. Myomas cause significant morbidity
and are the single most common indication for hysterectomy in the United States,
representing a major personal and public health concern worldwide. Recent
research on the cellular and molecular biology of myomas has enabled us to
understand better the pathogenesis and pathophysiology of this tumor, but more
remains to be done.
The structure of human telomeric DNA is controversial; it depends upon
the sequence contexts and the methodologies used to determine it. The
solution structure in the presence of K
is particularly interesting, but the
structure is yet to be elucidated, due to possible conformational heterogen-eity.
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Genetic and phylogenetic evolution of HIV-1 in a low subtype heterogeneity epidemic: the Italian example...