Xem 1-18 trên 18 kết quả Genetic modification
  • Genetically modified foods and food products derived from genetically engineered organisms are among a number of biotechnological developments intended to improve shelf life, nutritional content, flavor, color, and texture, as well as agronomic and processing characteristics. Although in popular parlance the term genetically modified often is used interchangeably with genetically engineered, in this report genetic modification refers to a range of methods used to alter the genetic composition of a plant or animal, including traditional hybridization and breeding.

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  • Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Genetic modification of alternative respiration in Nicotiana benthamiana affects basal and salicylic acid-induced resistance to potato virus X

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  • Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Genetic modification of Bluetongue virus by uptake of “synthetic” genome segments

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  • Transcriptional activation can be divided into three main mechanisms: 1. Events that alter chromatin structure can enhance the access of transcription factors to DNA. For example, histone acetylation generally opens chromatin structure and is correlated with transcriptional activation. 2. Posttranslational modifications of transcription factors, such as phosphorylation, can induce the assembly of active transcription complexes.

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  • GMO CN gen mở ra tiền đồ to lớn trong việc tạo ra các cây trồng chuyển gen ( GMC= Genetic Modification Containment hay GMO = Genetically Modified Organism): Cây thuốc lá là cây chuyển gen đầu tiên được đưa vào ứng dụng (1983). Sau đó là cây bông kháng sâu và kháng cỏ dại (1986). Khi đó chỉ mới có 5 loại GMC được đưa ra thử nghiệm. Đến năm 1992 số GMC đã tăng lên đến 675 loại.

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  • This book came about initially as a result of informal discussions between the authors, all of whom are involved directly, to a greater or lesser extent, with agricultural science and research.

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  • Different types of mutation can vary in size, from structural variants to single base-pair substitutions, but what they all have in common is that their nature, size and location are often determined either by specific characteristics of the local DNA sequence environment or by higher order features of the genomic architecture. The genomes of higher organisms are now known to contain "pervasive architectural flaws" in that certain DNA sequences are inherently mutation prone by virtue of their base composition, sequence repetitivity and/or epigenetic modification....

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  • Biodiversity forms patterns not just across space, but also across time. New species emerge, old ones become extinct; rates of diversification speed up and slow down. These long-term patterns in evolution get their start in the generation-to- generation processes of natural selection, genetic drift, and reproductive isolation. When a lineage of organisms evolves over a few million years, these processes can potentially produce a wide range of patterns (see ). Natural selec- tion may produce a significant change in a trait such as body size, for example.

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  • Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học quốc tế đề tài: Inclusion of genetically identical animals to a numerator relationship matrix and modification of its inverse

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  • Susan L.Lindquist*† and Steven Henikoff‡ *Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 02142; and ‡The Fred Hutchinson Cancer Research Center, Seattle, WA 98109 Over the past half-century, the central dogma, in which DNA makes RNA makes protein, has dominated thinking in biology, with continuing refinements in understanding of DNA inheritance, gene expression, and macromolecular interactions. However, we have also witnessed the elucidation of epigenetic phenomena that violate conventional notions of inheritance.

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  • In yeast, the N-linked oligosaccharide modification in the Golgi apparatus is initiated by a1,6-mannosyltransferase (encoded by theOCH1gene) with the addition of mannose to the Man8GlcNAc2or Man9GlcNAc2 endoplas-mic reticulum intermediates. In order to characterize its enzymatic proper-ties, the soluble form of the recombinant Och1p was expressed in the methylotrophic yeastPichia pastorisas a secreted protein,

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  • Proteins are covalently modified with a variety of lipids, including fatty acids, isoprenoids, and cholesterol. Lipid modifications play important roles in the localization and function of proteins. The focus of this review is S-palmitoylation, the reversible addition of palmitate and other long-chain fatty acids to proteins at cysteine residues in a variety of sequence contexts.

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  • Protein-tyrosine phosphatases are tightly controlled by various mecha-nisms, ranging from differential expression in specific cell types to restricted subcellular localization, limited proteolysis, post-translational modifications affecting intrinsic catalytic activity, ligand binding and dimerization. Here, we review the regulatory mechanisms found to control the classical pro-tein-tyrosine phosphatases.

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  • The transcription factor hypoxia inducible factora-subunit (HIFa)is pivotal in the cellular response to the stress of hypoxia. Post-translational modification of HIFa by hydroxylase enzymes has recently been identified as a key oxygen sensing mechanism within the cell. The absence of the substrate oxygen prevents the hydroxylases from modi-fying HIFaduring hypoxia and allows dramatic up-regula-tion of both HIFaprotein stability and transcriptional activation capability.

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  • The cationic peptide antibiotic polymyxin has recently been reevaluated in the treatment of severe infections caused by gram negative bacteria. Methods: In this study, the genetic determinants for capsular polysaccharide level and lipopolysaccharide modification involved in polymyxin B resistance of the opportunistic pathogen Klebsiella pneumoniae were characterized. The expressional control of the genes responsible for the resistance was assessed by a LacZ reporter system.

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  • Efforts to isolate carrier protein-mediated synthases from natural product-producing organisms using reporter-linked post-translational modification have been complicated by the efficiency of the endogenous process. To address this issue, we chose to target endogenous phosphopantetheinyl transferases (PPTases) for inhibitor design to facilitate natural product syn-thase isolation through a chemical genetics approach.

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  • The envelope protein gp64 of the baculovirusAutographa californicanuclear polyhedrosis virus is essential for viral entry into insect cells, as the glycoprotein bothmediates pH-dependentmembrane fusionandbinds tohost cell receptors. Surface modification of baculovirus particles by genetic engineering of gp64 has been demonstrated by various strategies and thus has become an important and powerful tool in molecular biology.

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  • This chapter include objectives: Evaluate the effects of continuous variation, pleiotropic genes, lack of complete dominance, environmental modifications of genes, and epistasis on disease; understand the importance of crossing over in terms of gene assortment and construction of genetic maps; describe the many genetic disorders discussed in the text, their symptoms, relative frequency in specialized populations, and their genetic basis;...

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