Genome maintenance

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Genome-wide deletion mutant analysis reveals genes required for respiratory growth, mitochondrial genome maintenance and mitochondrial protein synthesis in Saccharomyces cerevisiae...

    pdf0p thulanh21 15-11-2011 19 1   Download

  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Advances in understanding genome maintenance...

    pdf0p thulanh22 20-11-2011 16 1   Download

  • Homologous recombination (HR) serves to eliminate deleterious lesions, such as double-stranded breaks and interstrand crosslinks, from chromosomes. HR is also critical for the preservation of replication forks, for telomere maintenance, and chromosome segregation in meiosis I. As such, HR is indispensable for the maintenance of genome integrity and the avoidance of cancers in humans. The HR reaction is mediated by a conserved class of enzymes termed recombinases.

    pdf32p taytrang001 25-12-2012 29 7   Download

  • Forty years ago, Congress asked the National Academies Committee on Science, Engineering, and Public Policy (COSEPUP)—the only joint policy committee of the National Academy of Sciences, National Academy of Engineering, and Institute of Medicine—to look at the relationship between basic research and national goals. That request, from the House Committee on Science and Astronautics in 1964, resulted in the report Basic Research and National Goals.

    pdf205p camchuong_1 04-12-2012 25 6   Download

  • DNA replication, the process of copying one double stranded DNA molecule to produce two identical copies, is at the heart of cell proliferation. This book highlights new insights into the replication process in eukaryotes, from the assembly of pre-replication complex and features of DNA replication origins, through polymerization mechanisms, to propagation of epigenetic states. It also covers cell cycle control of replication initiation and includes the latest on mechanisms of replication in prokaryotes. The association between genome replication and transcription is also addressed.

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  • Most (78%) mitochondrial genomes in the studied mutant strain of Drosophila subobscura have undergone a large-scale deletion (5 kb) in the coding region. This mutation is stable, and is transmitted intact to the offspring. This animal model of major rearrangements of mitochondrial genomes can be used to analyse the involvement of the nuclear genome in the production and maintenance of these rearrangements.

    pdf8p research12 01-06-2013 11 3   Download

  • Genomic assays. Unlike individual gene testing, such as testing for HER2, genomic assays analyze the activity of a group of normal and abnormal genes that can increase the risk of breast cancer coming back after treatment. This analysis can help decide if a person is likely to benefit from chemotherapy to reduce the risk of the cancer coming back. Two types of genomic assays for breast cancer are currently in use: Oncotype DX and MammaPrint.

    pdf10p taisaokhongthedung 09-01-2013 21 2   Download

  • he tumor suppressor, breast cancer susceptibility gene 1 (BRCA1), plays an integral role in the maintenance of genome stability and, in particular, the cellular response to DNA damage. Here, the emerging role of BRCA1 in nonhomologous end-joining-mediated DNA repair following DNA dam-age will be reviewed, as well as the activation of apoptotic pathways.

    pdf7p viettel02 19-02-2013 12 1   Download

  • One of the most drastic post-translational modification of proteins in eu-karyotic cells is poly(ADP-ribosyl)ation, catalysed by a family enzymes termed poly(ADP-ribose) polymerases (PARPs). In the human genome, 18 different genes have been identified that all encode PARP family members.

    pdf14p fptmusic 11-04-2013 16 1   Download

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