Xem 1-8 trên 8 kết quả Genomic heterogeneity
  • Our model identifies new explanations for why large and small firms make different insurance offer decisions; they are based on turnover rates and within-firm and between-firm heterogeneities. Large firms tend to have greater within-firm heterogeneity than small ones, and so they are more likely to have some employees who strongly desire health insurance and less likely to attract only workers who do not find health insurance attractive.

    pdf22p quaivatxanh 29-11-2012 21 5   Download

  • Sindbis virus (SV) is the prototype of alphaviruses which are a group of widely distributed human and animal pathogens. Heterogeneous nuclear ribonucleoprotein (hnRNP) A1 is an RNA-binding protein that shuttles between the nucleus and the cytoplasm. Our recent studies found that hnRNP A1 relocates from nucleus to cytoplasm in Sindbis virus (SV)-infected cells. hnRNP A1 binds to the 5′ UTR of SV RNA and facilitates the viral RNA replication and translation.

    pdf7p toshiba23 18-11-2011 24 4   Download

  • Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Genetics of childhood and adolescent depression: insights into etiological heterogeneity and challenges for future genomic research

    pdf6p panasonic02 15-12-2011 17 3   Download

  • Last decade major advances have been made in the field of mouse model engineering. Newly developed conditional mouse models have overcome important drawbacks in conventional mouse models. Conditional mouse models are especially suited for the development of models of sporadic human carcinomas. These models can control gene (in)activation in a time and/or tissue-specific manner. Here, we review two important conditional mouse model systems, based on the Tet off/on and the Cre-Lox system.

    pdf215p tom_123 15-11-2012 13 2   Download

  • We report here the direct evidence for the formation of alternative DNA structures in a plasmid DNA, termed pTIR10, containing a 0.23-kb pyrimidine/purine-biased (Pyr/Pur) stretch isolated from the rat genome. Long Pyr/Pur sequences are abundant in eukaryotic genomes, and they may modulate the biological activity of genes and genomes via formation of various types of triplex-related structures. The plasmid DNA in sodium acetate buffer (pH 4.35) was deposited on APS-modified mica, and after drying it was imaged with an atomic force microscope in air. ...

    pdf5p system191 01-06-2013 15 2   Download

  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: A statistical approach for detecting genomic aberrations in heterogeneous tumor samples from single nucleotide polymorphism genotyping data...

    pdf15p thulanh22 20-11-2011 17 1   Download

  • We used a PCR-based method to determine the genomic DNA sequences encoding phospholipases A2(PLA2s) from the venoms ofVipera aspis aspis(V. a. aspis),Vipera aspis zinnikeri (V. a. zinnikeri), Vipera berus berus(V. b. berus) and a neurotoxicV. a. aspissnake (neurotoxicV. a. aspis) from a population responsible for unusual neurotoxic envenomations in south-east France. We sequenced five groups of genes, each corresponding to a different PLA2.

    pdf10p fptmusic 16-04-2013 11 1   Download

  • Personalized cancer medicine is defined as medical care based on the particular biological characteristics of the disease process in individual patients. By using genomics and proteomics, individuals can be classified into subpopulations based on their susceptibility to a particular disease or response to a specific treatment. They may then be given preventive or therapeutic interventions that will be most effective given their particular characteristics.

    pdf95p mnemosyne75 02-02-2013 18 1   Download

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