Xem 1-8 trên 8 kết quả Genomic instability
  • Changes in the pattern of DNA methylation are commonly seen in human tumors. Both genome wide hypomethylation (insufficient methylation) and region-specific hypermethylation (excessive methylation) have been suggested to play a role in carcinogenesis2. A common cause of the loss of tumor-suppressor miRNAs in cancer is the silencing of primary transcripts by CpG island promoter by hypermethylation3.

    pdf400p yeutinh98 22-09-2012 23 4   Download

  • The inverted repeats present in a genome play dual roles. They can induce genomic instability and, on the other hand, regulate gene expression. In the present study, we report the distribution and sequence features of recombi-nogenic long inverted repeats (LIRs) that are capable of forming stable stem-loops or palindromes within the human genome.

    pdf13p viettel02 22-02-2013 12 1   Download

  • Understanding the biological basis of aging has fascinated people throughout recorded history, and is one of the great remaining scientific questions. The question has never been more important than now, as we anticipate the impact that a rapidly growing older population will have on the social, political, and medical landscape over the next 50 years. There is increasing evidence that aging involves damage to the genome, and it is certainly the case that such damage explains much of the coupling of most cancers to aging.

    pdf598p hyperion75 18-01-2013 20 5   Download

  • This book describes a course of cancer growth starting from normal cells to cancerous form and the genomic instability, the cancer treatment as well as its prevention in form of the invention of a vaccine. Some diseases are also discussed in detail, such as breast cancer, leucaemia, cervical cancer, and glioma. Understanding cancer through its molecular mechanism is needed to reduce the cancer incidence.

    pdf496p phoebe75 19-02-2013 24 5   Download

  • Bank accounts that are denominated in foreign currencies can offer some advantages to diasporas. First, in offering such foreign-currency denominated bank accounts, banks are the ones that shoulder the risk of foreign exchange. If account holders hold currency in local denomination, they are the ones who bear foreign currency risks. Foreign currency deposit (FCD) accounts have often been used by domestic savers to maintain the real value of their savings during times of macroeconomic instability.

    pdf25p machuavo 19-01-2013 25 3   Download

  • The Nbs1 protein associates with Mre11 and Rad50 proteins to form the Mre11–Rad50–Nbs1 complex, which plays an important role in the intracellular signaling pathway activated in response to DNA damage. Mutations in the genes for each of these three components of the Mre11– Rad50–Nbs1 complex result in human diseases characterized by genomic instability.

    pdf7p inspiron33 26-03-2013 16 3   Download

  • Cytolethal distending toxin, produced by several Gram-negative bacteria, and colibactin, secreted by several commensal and extraintestinal patho-genic Escherichia coli strains, are the first bacterial genotoxins to be described to date.

    pdf12p cosis54 04-01-2013 11 2   Download

  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Dynamic instability of the major urinary protein gene family revealed by genomic and phenotypic comparisons between C57 and 129 strain mice...

    pdf16p coxanh_8 05-11-2011 15 1   Download

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