Genomic technology

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  • This is a book about medical genomics, a new field that is attempting to combine knowledge generated from the Human Genome Project (HGP) and analytic methods from bioinformatics with the practice of medicine. From my perspective as a research molecular biologist, genomics has emerged as a result of automated high-throughput technologies entering the molecular biology laboratory and of bioinformatics being used to process the data.

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  • Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Genomics technology for assessing soil pollution...

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  • The birth of livestock genomics 15 years ago was inspired by the human genome initiative and the potential for capturing both its technologies and massive comparative data sets for application to livestock species, most of which are mammals. We are currently reaping the benefits of these efforts, with sequencing projects completed or ongoing in chickens, cattle, pigs, and horses and valuable mapping resources developed for others such as sheep and turkeys.

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  • Tham khảo sách 'dna methylation – from genomics to technology edited by tatiana tatarinova and owain kerton', y tế - sức khoẻ, y học thường thức phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả

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  • Tham khảo sách 'biomems and biomedical nanotechnology - volume ii micro/nano technology for genomics and proteomics', giáo dục - đào tạo, cao đẳng - đại học phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả

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  • It has been a privilege to watch the growth of RNA interference technology over the last ten years. Starting with a mixture of curiosity and chagrin, the field has grown into a substantial enterprise which impacts (and utilizes resources from) virtually every field of biomedical research. Research in RNAi derives from a set of apparently unconnected observations: strange pigment patterns in plants, unexpected failures and successes in antisense and overexpression studies, small regulatory RNAs in bacteria.

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  • Chapter 10 introduce to the genomes and proteomes. The main contents of this chapter include all of the following: Large-scale genome mapping and analysis, major insights from the human and model organism genome sequences, global analysis of genes and their mRNAs, global analysis of proteomes, repercussions of the human genome project and high-throughput technology.

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  • The genomics revolution of the past decade has greatly enhanced our understanding of the genetic composition of living organisms including many plant species of economic importance. Complete genomic sequences of Arabidopsis and several major crops, together with high-throughput technologies for analyses of transcripts, proteins and mutants, provide the basis for understanding the relationship between genes, proteins and phenotypes.

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  • Flow cytometry is a technology that simultaneously measures and analyses multiple physical characteristics of single particles, usually cells, as they flow in a fluid stream through a beam of light. The properties measured include a particle’s relative size (represented by forward angle light scatter), relative granularity or internal complexity (represented by right-angle scatter), and relative fluorescence intensity.

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  • Researchers have theorized that anti-inflammatory medications may help prevent diseases, such as coronary artery diseases (CAD), cardio vascular diseases (CVD), stroke, colon cancer and Alzheimer’s. Several recent findings from different laboratories in the world employing case-control human studies and/or specific animal models for chronic human diseases support these ideas.

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  • In recent years, completion of the sequencing of the human genome as well as the genomes of dozens of other organisms and subsequent development of tools for comprehensive analysis of other cellular constituents have revolutionized biology. These new technologies, referred to broadly as “genomics,” have integrated biologic sciences with information sciences and engineering.

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  • The Computer Revolution: Progress in computer technology: Underpinned by Moore’s Law. Makes novel applications feasible: Computers in automobiles, Cell phones, Human genome project, World Wide Web, Search Engines. Computers are pervasive.

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  • The rapid adoption of the Internet and computing technologies by all sectors of modern society has made them an indispensable part of our daily work and life. Access to these resources is taken for granted by public agencies providing services to the community, by those who conduct business and commerce, and by those who use them to stay current on public affairs and in touch with their families and friends on a daily basis.

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  • Since the discovery of X rays by Roentgen in 1895, the ionizing radiation has been extensively utilized in a variety of medical and industrial applications. And it has also played crucial roles in development of modern sciences and technologies, as witnessed by more than 60 Nobel Prize winners awarded for achievements in atomic sciences and ionizing radiation-related researches.

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  • Changes in the pattern of DNA methylation are commonly seen in human tumors. Both genome wide hypomethylation (insufficient methylation) and region-specific hypermethylation (excessive methylation) have been suggested to play a role in carcinogenesis2. A common cause of the loss of tumor-suppressor miRNAs in cancer is the silencing of primary transcripts by CpG island promoter by hypermethylation3.

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  • The 2005 Declaration discussed above and the Universal Declaration on the Human Genome and Human Rights, 1997 are both resolutions passed in the General Assembly. They have no immediate binding effect. They play a signifi cant role in the formation of customary international law. There are many different forms of law making in international law and although an international convention or a treaty is a source of binding rules, the importance of other methods of formation of international law cannot be underestimated.

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  • Toxicogenomics has been described as a discipline combining ex- pertise in toxicology, genetics, molecular biology, and environmental health to elucidate the response of living organisms to stressful environ- ments. It includes the study of how genomes respond to toxicant expo- sures and how genotype affects responses to toxicant exposures. As the technologies for monitoring these responses rapidly develop, it is critical that scientists and regulators are confident that the technologies are reli- able and reproducible and that the data analyses have been validated.

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  • Glofish is the first transgenic animal approved to be consumed by human in the USA  The insertion of different constructs of GFP into the fish genomes to give different green colors.The idea for recombinant DNA was first proposed by Peter Lobban, a graduate student of Prof. Dale Kaiser in the Biochemistry Department at Stanford University Medical School. The first publications describing the successful production and intracellular replication of recombinant DNA appeared in 1972 and 1973.

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  • Nutrigenomics, proteomics and metabolomics are three new disciplines that will contribute to the rapid development of functional foods. Bioinformatics is a new tool that uses computer database technology to integrate data from multiple, and sometimes disparate, disciplines. Already these disciplines and tools have improved our understanding of food science and human nutrition. Discoveries in genetics make it possible to understand the effects of nutrients in processes at the molecular level in the body and also the variable effects of dietary components on each individual.

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  • 30 April 2004 Genome Biology 2004, 5:324 The electronic version of this article is the complete one and can be found online at http://genomebiology.com/2004/5/5/324 © 2004 BioMed Central Ltd reviews A report on the 5th annual Advances in Genome Biology and Technology (AGBT) and Automation in DNA Mapping and Sequencing (AMS) meeting, Marco Island, USA, 4-7 February 2004.

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