Glucose system

Xem 1-20 trên 27 kết quả Glucose system
  • The field of molecular imaging/nuclear medicine continues to build excitement for the medical community as a whole. To be able to visualize fundamental molecular and biochemical processes in patients in a meaningful way has truly become reality. Of all the available molecular probes and tools it is clear that FDG with PET-CT is one of the true clinical success stories. Very few would have been able to predict the eventual impact of a simple glucose analog as a marker for imaging cancer, hibernating myocardium, Alzheimer’s disease, epilepsy and many other important disease processes....

    pdf277p echbuon 02-11-2012 32 7   Download

  • Biomedical Engineering is a highly interdisciplinary and well established discipline spanning across engineering, medicine and biology. A single definition of Biomedical Engineering is hardly unanimously accepted but it is often easier to identify what activities are included in it. This volume collects works on recent advances in Biomedical Engineering and provides a bird-view on a very broad field, ranging from purely theoretical frameworks to clinical applications and from diagnosis to treatment....

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  • Biomedical Engineering is a highly interdisciplinary and well established discipline spanning across engineering, medicine and biology. A single definition of Biomedical Engineering is hardly unanimously accepted but it is often easier to identify what activities are included in it. This volume collects works on recent advances in Biomedical Engineering and provides a bird-view on a very broad field, ranging from purely theoretical frameworks to clinical applications and from diagnosis to treatment....

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Research Glucose sensing in the pancreatic beta cell: a computational systems analysis...

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  • All living cells require metabolic substrates (e.g., oxygen, amino acids, glucose) and a mechanism by which they can remove byproducts of metabolism (e.g., carbon dioxide, lactic acid). Single-cell organisms exchange these substances directly with their environment through diffusion and cellular transport systems. In contrast, most cells of large organisms have limited or no exchange capacity with their environment because their cells are not in contact with the outside environment.

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  • Estrogen is known to influence glucose homeostasis but the role of estrogen receptors in muscle glucose metabolism is unknown. Therefore, we investigated the expression of the two estrogen receptors, ERa and ERb and their influence on regulation of GLUT4, and its associated structural protein, caveolin-1, in mouse muscle. ERaand ERbare co-expressed in the nuclei of most muscle cells and their levels were not affected by absence of estradiol (in aromatase knockout, ArKO, mice).

    pdf6p inspiron33 26-03-2013 17 3   Download

  • UDP-d-glucuronic acid and UDP-d-xylose are required for the biosynthesis of glycosaminoglycan in mammals and of cell wall polysaccharides in plants. Given the importance of these glycans to some organisms, the development of a system for production of UDP-d-glucuronic acid and UDP-d-xylose from a common precursor could prove useful for a number of applications.

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  • Glucokinase (GK) is the central player in glucose-stimulated insulin release from pancreatic b-cells, and catalytic activation by a-D-glucose binding has a key regulatory function. Whereas the mechanism of this activation is well understood, on the basis of crystal structures of human GK, there are no similar structural data on ATP binding to the ligand-free enzyme and how it affects its conformation.

    pdf15p cosis54 05-01-2013 12 2   Download

  • Thirteen glucose analogues bearing electrophilic groups were synthesized (five of themfor the first time) and screened as inhibitors of the glucose transporter (EII Glc )of the Escherichia coli phosphoenolpyruvate–sugar phospho-transferase system (PTS). 2¢,3¢-Epoxypropyl b-D-glucopyr-anoside (3a) is an inhibitor and also a pseudosubstrate. Five analogues are inhibitorsofnonvectorialGlcphosphorylation by EII Glc but not pseudosubstrates.

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  • We have investigated the crr gene of Streptomyces coelicolor that encodes a homologue of enzyme IIAGlucose of Escherichia coli, which, as a component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS) plays a key role in carbon regulation by triggering glucose transport, carbon catabolite repression, and inducer exclusion. As in E. coli, the crr gene of S. coelicolor is genetically associated with the ptsI gene that encodes the general phosphotransferase enzyme I.

    pdf8p research12 01-06-2013 8 2   Download

  • The glycolytic pathway converts glucose to pyruvate and produces two molecules of ATP per glucose only a small fraction of the potential energy available from glucose. Under anaerobic conditions, pyruvate is reduced to lactate in animals and to ethanol in yeast, and much of the potential energy of the glucose molecule remains untapped. In the presence of oxygen, however, a much more interesting and thermodynamically complete story unfolds.

    ppt56p tangtuy15 30-06-2016 2 2   Download

  • As shown in previous chapter, the metabolism of sugars is an important source of energy for cells. Animals, including humans, typically obtain significant amounts of glucose and other sugars from the breakdown of starch in their diets. Glucose can also be supplied via breakdown of cellular reserves of glycogen (in animals) or starch (in plants). What is the nature of gluconeogenesis, the pathway that synthesizes glucose from noncarbohydrate precursors; how is glycogen synthesized from glucose; and how are electrons from glucose used in biosynthesis?

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  • Time-dependent regulation analysis is a new methodology that allows us to unravel, both quantitatively and dynamically, how and when functional changes in the cell are brought about by the interplay of gene expression and metabolism. In this first experimental implementation, we dissect the initial and late response of baker’s yeast upon a switch from glucose-lim-ited growth to nitrogen starvation.

    pdf16p viettel02 20-02-2013 10 1   Download

  • The mechanisms underlying increased cardioprotection in younger female mice are unclear. We hypothesized that serine-threonine protein kinase (protein kinase B; Akt) triggers a metabolic gene switch (decreased fatty acids, increased glucose) in female hearts to enhance mitochondrial bio-energetic capacity, conferring protection against oxidative stress.

    pdf7p media19 04-03-2013 10 1   Download

  • UhpC is a membrane-bound sensor protein inEscherichia colirequired for recognizing external glucose-6-phosphate (Glc6P) and induction of the transport protein UhpT. Recently, it was shown that UhpC is also able to transport Glc6P.In this studywe investigatedwhether these transport and sensing activities are obligatorily coupled in UhpC.We expressed a His-UhpC protein in a UhpC-deficientE. coli strain and verified that this construct does not alter the basic biochemical properties of the Glc6Psensor system....

    pdf8p tumor12 20-04-2013 11 1   Download

  • WhenSaccharomyces cerevisiaecells, grown in galactose, glucose or mannose, were treated with 1.5 mMhydrogen peroxide (H2O2) for 30 min, an important decrease in the ATP, and a less extensive decrease in the GTP, CTP, UTP and ADP-ribose levels was estimated. Concomitantly a net increase in the inosine levels was observed. Treatment with 83mMmenadionepromoted theappearanceof acompound similar to adenosine but no appreciable changes in the nucleotide content of yeast cells, grown either in glucose or galactose....

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  • Lecture Biology - Chapter 7: Pathways that harvest chemical energy. The topics discussed in this chapter are: How does glucose oxidation release chemical energy? What are the aerobic pathways of glucose metabolism? How is energy harvested from glucose in the absence of oxygen? How does the oxidation of glucose form ATP? Why does cellular respiration yield so much more energy than fermentation? How are metabolic pathways interrelated and controlled?

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  • Chapter 26 - Endocrinology, this chapter describe how hormones secreted from the endocrine glands help body maintain homeostasis; describe anatomy and physiology of pancreas and how its hormones maintain normal glucose metabolism; discuss pathophysiology as a basis for key signs and symptoms, patient assessment, and patient management for diabetes and diabetic emergencies of hypoglycemia, diabetic ketoacidosis, and hyperosmolar hyperglycemic nonketotic syndrome;...

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  • In this chapter: Write the overall reaction for glucose breakdown and show that it is a redox reaction; discuss the role of oxidation-reduction enzymes; state the four phases of cellular respiration and tell where each occurs in the cell; contrast the energy-investment step of glycolysis with the energy-harvesting steps;...

    ppt46p tangtuy07 02-04-2016 3 1   Download

  • Unlike in dry milling, where the entire mash is fermented, in wet milling only the starch is fermented. The starch is then cooked, or liquefied, and an enzyme added to hydrolyze, or segment, the long starch chains. In dry milling, the mash, which still contains all the feed coproducts, is cooked and an enzyme added. In both systems a second enzyme is added to turn the starch into a simple sugar, glucose, in a process called saccharification. Saccharification in a wet mill may take up to 48 hours, though it usually requires less time, depending on the amount of enzyme used.

    pdf222p loixinloi 08-05-2013 25 8   Download

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