Glycosylation and glycoproteins

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  • A clustering of the disease among close relatives has also been shown, although there is no consensus on which inheritable genetic defects are involved. In spite of extensive research, reliable findings on risk factors relating to lifestyle, diet or the environment remain elusive. Possible lifestyle risk factors are high intakes of α-linolenic acid (a polyunsaturated fatty acid in vegetables and dairy products) and calcium.

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  • The presence or absence of diseases is strongly associated with individual health but did not fulfil the multidimensional concept of health. Health is characterised by dynamic and multi-factorial influences on the physical, psychological and social functioning of an individual. On the one hand, an objective health status includes the set of diagnosed physiological and psychological diseases of an individual.

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  • Taken as a whole, the German cinema is both more and less than the sum of its films. When one thinks of individual titles, quite a few, especially from the 1920s and early 1930s, have entered the canon, have become cultural icons the world over. Yet in these very same classics, the brilliant and the dark sides of their genius appear not only close together but inextricable. If we think of The Golem, The Cabinet of Dr Caligari, Nosferatu and Dr Mabuse: these are titles which by themselves evoke the spirit of an age, conjuring up...

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  • The health impacts of a range of air pollutants are evaluated in this paper. However, to avoid double counting, it follows Kunzli et al. (1999) in using PM10 (particulate matter with an equivalent aerodynamic diameter of 10 µm or less) as the single indicator (the index pollutant) of the health impacts of common ambient air pollutants, and including non-overlapping health endpoints2 only when calculating the total health impact of air emissions.

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  • In the course of updating the earlier research, the authors reviewed the 12 regulatory categories covered in the original report and eliminated three of them (restrictions on portraying children, athletic achievement, and intoxication) because of their limited scope and the difficulty in enforcing them. Two of the earlier placement categories (outdoor ads near children and outdoor ads near schools, playgrounds, and churches) had substantial overlap and were combined into a single “outdoor ads” category.

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  • An additional element in the prevention of introduction and spread of disease is the use of vaccination. The manual does not cover this aspect but the importance of an appropriate vaccination strategy is acknowledged, and vaccination as a possible risk management measure should form part of the overall biosecurity assessment and strategy. The purpose of the manual is to establish a minimum set of biosecurity guidelines, applicable to all poultry producers (including ratites) from hatcheries to the point of delivery at the processor.

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  • Tumor markers are secreted, released, or leaked into the interstitial fluids, and thus into the lymph, and finally (or directly) into the bloodstream, where they become detectable in serum samples. To be able to enter the bloodstream directly, larger molecules, often proteins, are cleaved into truncated forms or fragments, which are sometimes specific to the protease micro-environment of the tumor. Tumor markers can be associated with patient diagnosis, prognosis, clinical management, and follow-up.

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  • Capital flows are highly liquid, can respond abruptly to changes in economic and financial conditions, and exercise a primary influence on exchange rates and through those on global flows of goods and services. Economists generally attribute recent rise and fall in foreign investment to a number of factors, including a “safe haven” effect during times of uncertainty; comparatively favorable returns on investments relative to risk, a surplus of saving in other areas of the world, the well-developed U.S. financial system, and the overall stability of the U.S. economy.

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  • The distribution of scores is also interesting (Figure 2). The modal (the most frequently achieved) score in many countries is 6 (Albania, Armenia, Hungary, Ireland, Malaysia, Norway, Peru, Poland, UK, BVI), whilst some countries have a modal score of 7 (Czech Republic, and Estonia). Just one country, Germany, has the maximum value as the modal value. By looking at the distribution we can see that some countries, such as Albania, Norway, and South Africa have a relatively large proportion of the population scoring between 0 and 2.

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  • Investors in quoted companies come in all shapes and sizes with a multiplicity of requirements, risk tolerances, investment styles and processes. Indeed no two investors are the same and may actually approach the purchase of a company’s shares from equal and opposite directions. It is fortunate that this is the case as it takes buyers and sellers to make a market. From an investor relations perspective, it is therefore important that quoted companies know their investors.

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  • Strategic Approach: 1) Identify genetic risk factors for neurocognitive and psychiatric illnesses through high throughput genotyping, proteomics or next generation sequencing platforms, 2) leverage Canada's unique populations and cohorts for the genetic analysis, 3) develop new phenotyping modalities to stratify populations for analysis. Global Context: All neurocognitive and psychiatric disorders of childhood seen in Canada occur worldwide.

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  • There are many ways to find a doctor for a second opinion. You can ask your doctor, a local or state medical society, a nearby hospital, or a medical school for names of specialists. Other sources can be found in the NCI fact sheet How To Find a Doctor or Treatment Facility If You Have Cancer. Nonprofit groups with an interest in lymphoma may be of help. Many such groups are listed in the NCI fact sheet National Organizations That Offer Services to People With Cancer and Their Families. Page 46 tells how to get NCI fact sheets....

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  • Professional care at birth can help reduce maternal mor tality. The proportion of women who deliver with the assistance of a skilled health-care provider - doctor , nurse, midwife - is highly correlated with materna mortality ratios. Trends in this indicator during the 1990s suggest that significant progress has been made in developing countries, with an overall increase from 41% to 57% between 1990 and 2003. However , there are important differences across regions, as shown in Figure 6.

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  • In the last part of the 20th century scientists discovered drugs that made the brain more resistant to ischemia, to such an extent that cerebral tissue treated with them was only little damaged, or was not damaged at all, by an ischemic insult that badly damaged control, untreated tissue. It was the beginning of a very exciting era in neuroscience research, a period when academic and industrial scientists all pursued the research of a “neuroprotectant” that could defend the ischemic brain from irreversible damage.

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  • It is worth emphasising however that we now appear to have a range of compounds that in some patients at least, and for some time, help to control positive psychotic symptoms. While this is very important, this benefit may come with associated adverse consequences in other ways for some patients, such as cardio-metabolic side effects that can have a major impact on physical health. Clinicians therefore will need to exercise careful and skilled judgement about which antipsychotic to use in order to benefit individual patient’s symptoms, and minimise adverse health effects.

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  • The veterinary sector has witnessed considerable change in recent years, and this has had a significant impact on the wider veterinary business landscape. Most noteworthy, perhaps, has been the change at the global level in the focus of animal welfare, with a growth in small/companion animal care and a reduction in large animal work (Lowe, 2009). This has resulted in increased competition amongst veterinary practices and the recognition that veterinary services need to be appropriately marketed.

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  • After the correct placement in the muscle head, the needles were retrieved and the neochordae platform was secured with extracorporeal knots tied by the assistant using a closed knot pusher. Each neochordae loop was attached to the edge of the prolapsing leaflet by applying a single-armed V60 U-clip per loop. The singlearmed U-clip was placed in the leaflet edge with a robotic large needle holder and the neochordae loop was captured in the open clip circle. The U-clip was deployed by pulling the needle off the clip portion, securing the neochordae loop to the leaflet...

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  • Consequently, it is necessary to integrate the information of all the spectral images to classify tissues. Multi-spectral image processing techniques [1-3] are hence employed to collect spectral information for classification and of clinically critical values. In this paper, a new classification approach was proposed, it is called unsupervised Vector Seeded Region Growing (UVSRG). The UVSRG mainly select seed pixel vectors by means of standard deviation and relative Euclidean distance.

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  • Concerns about rising health care costs and affordability of health care for families persist despite the enactment of comprehensive health reform legislation in March 2010 (the Affordable Care Act, or ACA). 1 The ACA changed the health care landscape considerably by providing significant financial assistance to help people with low and moderate incomes afford coverage and associated cost sharing.

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  • The calculation of indirect and induced (multiplier) impacts is made on the basis of input-output (I-O) accounting tables. These matrices show the pattern of purchases and sales between industries in the economy. Base tables are constructed at a national level, and tables for smaller regions are derived by regionalizing the core BEA tables to reflect inter-regional purchasing patterns.

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