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Growth factors are a group of proteins that regulate a wide variety of cel-lular processes, including proliferation, differentiation, motility, adhesion,
and apoptosis of target cells. They play crucial roles in the formation and
maintenance of tissue architecture in embryonic development and adult
We previously reported that the inhibition of catalase and glutathione per-oxidase activities by treatment with 3-amino-1,2,4-triazole (ATZ) and mer-captosuccinic acid evoked sustained increases in the levels of reactive
oxygen species and apoptosis in rat primary hepatocytes.
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Hepatic apoptosis is elevated in patients with non-alcoholic steatohepatitis
and is correlated with the severity of the disease. Long-chain saturated
fatty acids, such as palmitate, induce apoptosis in liver cells. The present
study examined adiponectin-mediated protection against saturated fatty
acid-induced apoptosis in the human hepatoma cell line, HepG2.