Internal Medicine is designed to provide the busy clinician
with precisely the information needed where and when it is
needed. The Associate Editors and contributors are internationally
recognized authorities, and they have organized the
content specifically so as to convey the essentials necessary for
diagnosis, differential diagnosis, management, treatment and
follow-up. Many topics start with a “What To Do First” heading
which brings the collective experience and guidance of top
experts to bear on the “up front” considerations the clinician
The overall approach to learning medicine can be summed up in two questions: What is it? What do you do for it? The
goal is to have a concise review that is readable and easy to follow with algorithms, diagrams, radiographs, and pathologic findings.
This book is divided into subspecialty topics, each chapter written by an author(s) with clinical expertise in the designated
topic. Images and tables are provided. Each chapter has bulleted items that highlight key points. These may be summary points
from previous paragraphs or new points. Bulleted items also address typical clinical scenarios.
Peripheral blood smear from patients with membrane-cytoskeleton abnormalities. A. Hereditary spherocytosis. B. Hereditary elliptocytosis, heterozygote. C. Elliptocytosis, with both alleles of the α-spectrin gene mutated. [From L Luzzatto, in J Gribben and D Pravan (eds): Molecular Hematology, 2d edition. Oxford, Blackwell, 2005; with permission.]
Table 101-3 Inherited Diseases of the Red Cell MembraneCytoskeleton
Chromoso mal Location
Protei n Produced s)
Disease( with s
Evaluation Methods in Medical Informatics, Second Edition is a heavily updated and revised volume based on editors Friedman and Wyatt's successful first edition. This book incorporates the solid foundation of evaluation theories, methods, and techniques laid out in the first edition, and builds on it to include case studies from real world situations. Designed as a guide for both the informatics novice and the seasoned professional seeking a comprehensive resource, this book explores information systems evaluation from the ground up.
I am pleased to have had the opportunity to present an overview of red cell membranes
in normal and disease states with my background of nearly 30 years in this
area of research.
I believe that this kind of publication on red cell membrane is a very timely summary
of all the results obtained by the tremendous efforts worldwide by all of the
scientists in this field during the past few decades.
As reviewed in Chapter 1, the general concepts of red cell membrane abnormalities
and the categories of each red cell membrane disorder are now well established.
The 20th century brought us the birth of the atomic age, with Albert
Einstein’s understanding that E = MC2 in 1905, Ernest Rutherford’s theory
of the structure of the atom in 1911, and the first sustained nuclear reaction
in Chicago in 1942. While it brought the promise of a robust use of
nuclear technologies for peaceful purposes, it also brought the reality of
nuclear weapons in 1945. Those initial weapons were large, heavy, and
complex to make and use. Moreover, only nations had nuclear weapons,
not individuals or groups.
To see the world as a web of information is a recent view. Humanity has contemplated
the source and character of our knowledge since the dawn of time, but the
present technologically oriented civilization demands a more concrete concept.
Knowledge has been replaced by information. The information has to be carried
by physical objects, and these are described by the theories of physics. Thus, we
have to develop a theory for information coded in physical objects.
Long ago, scientists developed formal descriptions of classical information
transfer and its manipulation.