Xem 1-8 trên 8 kết quả Hormonal intermediates
  • We have shown that hormone-induced downregulation of luteinizing hor-mone receptor (LHR) in the ovary is post-transcriptionally regulated by an mRNA binding protein. This protein, later identified as mevalonate kinase (MVK), binds to the coding region of LHR mRNA, suppresses its transla-tion, and the resulting ribonucleoprotein complex is targeted for degrada-tion.

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  • Growth and productivity of higher plants are adversely affected by various environmental stresses which are of two main types, biotic and abiotic, depending on the source of stress. Broad range of abiotic stresses includes osmotic stress caused by drought, salinity, high or low temperatures, freezing, or flooding, as well as ionic, nutrient, or metal stresses, and others caused by mechanical factors, light, or radiation.

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  • Liver metabolism is influenced by hormones and nutrients. Amino acids such as glutamine or leucine induce an anabolic response, which resembles that of insulin in muscle and adipose tissue. In this work, the signalling pathways and the effects of insulin were compared to those of glutamine and leucine in isolated hepatocytes from normal and streptozotocin-diabetic rats.

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  • The expansion of DNA repeat sequences is associated with many genetic diseases in humans. Simple bulge DNA structures have been implicated as intermediates in DNA slippage within the DNA repeat regions. To probe the possible role of bulged structures in DNA slippage, we designed and synthesized a pair of simple chiral spirocyclic compounds [Xi Z, Ouyang D & Mu HT (2006)Bioorg Med Chem Lett16, 1180–1184],

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  • Resonance Raman spectroscopy has been used to observe changes in the iron–ligand stretching frequency in photo-product spectra of the proximal cavitymutant ofmyoglobin H93G. The measurements compare the deoxy ferrous state of the heme iron in H93G(L), where L is an exogenous imidazole ligand bound in the proximal cavity, to the pho-tolyzed intermediate of H93G(L)*CO at 8 ns.

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  • Recent discoveries have indicated that the hormone hepcidin plays a major role in the control of iron homeostasis. Hepcidin regulates the iron level in the blood through the interaction with ferroportin, an iron exporter molecule, causing its internalization and degradation.

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  • ent-Kaurene is a tetracyclic diterpene hydrocarbon and a biosynthetic intermediate of the plant hormone gibberellins. In flowering plants, ent-kaurene is biosynthesized from geranylgeranyl diphosphate (GGDP) by two distinct cyclases,ent-copalyl diphosphate synthase (CPS) and ent-kaurene synthase (KS).

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  • After studying this chapter you will be able to: Know which hormones stimulate fat catabolism; know how acyl-CoAs are formed; know how acyl-CoAs are transported from the cytosol to the mitochondria; know the enzymatic steps of normal β-oxidation. Be able to draw the intermediates of one round of β-oxidation, know the co-enzymes and co-substrates involved in each step;...

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