The brain is a physical organ just like the heart or lungs or liver and, as such, its functioning can be
affected by our environment, particularly the substances we put in our bodies. I first became aware of
smart drugs from an article in Omni magazine some twenty years ago while I was attending college.
It was also at that time that I was becoming aware of health foods, and the article so impressed me
that, while other students were taking speed and No-Doz to cram for exams, I was gobbling hand-fuls
of vitamins. While my approach was undoubtedly too haphazard and belated to have...
N-tert-Butyl-N,N¢-dibenzoylhydrazine and its analogs are
nonsteroidal ecdysone agonists that exhibit insect molting
hormonal and larvicidal activities. The interaction mode of
those ecdysone agonists with the heterodimer of the ecdy-sone receptor andultraspiracle has not been fully elucidated.
We expressed the ecdysone receptor B1 and the ultraspiracle
of the lepidopteran,Chilo suppressalis,using anin vitro
transcription/translation system and confirmed, using gel-shift assays, that the proteins functionas ecdysone receptors.
We also analyzed their ligand-binding affinity. ...
This chapter provides a brief overview of the immune response as background for understanding the
mechanism of action of immunomodulatory agents. The general principles of pharmacological
immunosuppression are discussed in the context of potential targets, major indications, and
unwanted side effects.
Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are rare and heterogeneous
neoplasms with overall increasing incidence, but not an associated increase in survival rate
over the past few decades. Tumors originate from at least 16 different cells of diffuse
endocrine system (DES), scattered through mucosa of gastrointestinal tract. They are mainly
sporadic, but sometimes exhibit familial inheritance.