The 3 billion base pair sequence of the human genome is now available, and attention is focusing on annotating it to extract biological meaning. I will discuss what we have obtained, and the methods that are being used to analyse biological sequences. In particular I will discuss approaches using stochastic grammars analogous to those used in computational linguistics, both for gene finding and protein family classification.
Chapter 10 introduce to the genomes and proteomes. The main contents of this chapter include all of the following: Large-scale genome mapping and analysis, major insights from the human and model organism genome sequences, global analysis of genes and their mRNAs, global analysis of proteomes, repercussions of the human genome project and high-throughput technology.
We used the genotyping data generated by the International HapMap Project
to study the patterns of linkage disequilibrium (LD) in human genic regions.
LD patterns for 11 998 genes from 11 HapMap populations were identified
by analyzing the distribution of haplotype blocks.
(BQ) Part 1 book "Thompson & Thompson genetics in medicine" presents the following contents: Introduction to the human genome, human genetic diversity-mutation and polymorphism principles of clinical cytogenetics and genome analysis, the chromosomal and genomic basis of disease-disorders of the autosomes and sex chromosomes, genetic variation in populations,...
This is a book about medical genomics, a new field that is
attempting to combine knowledge generated from the Human
Genome Project (HGP) and analytic methods from bioinformatics
with the practice of medicine. From my perspective as
a research molecular biologist, genomics has emerged as a result
of automated high-throughput technologies entering the molecular
biology laboratory and of bioinformatics being used to
process the data.
Harrison's Internal Medicine Chapter 62. Principles of Human Genetics
Impact of Genetics on Medical Practice
Impact of Genetics on Medical Practice: Introduction
The beginning of the new millennium was marked by the announcement that the vast majority of the human genome had been sequenced. This milestone in the exploration of the human genome was preceded by numerous conceptual and technological advances.
Table 62-1 Selected Databases Relevant for Genomics and Genetic Disorders
National Center Biotechnology Information (NCBI) for
Molecular biology information, public databases, computational
Extensive links to other
databases, genome resources, tutorials and
National Human Genome
information about the human genome sequence, genomes of other organisms, and research genomic ...
The Genetic Map
Given the size and complexity of the human genome, initial efforts aimed at developing genetic maps to provide orientation and to delimit where a gene of interest may be located. A genetic map describes the order of genes and defines the position of a gene relative to other loci on the same chromosome. It is constructed by assessing how frequently two markers are inherited together (i.e., linked) by association studies. Distances of the genetic map are expressed in recombination units, or centiMorgans (cM).
The Human DNA Sequence
The complete DNA sequence of each chromosome provides the highest resolution physical map. The primary focus of the HGP was to obtain DNA sequence for the entire human genome as well as model organisms. Although the prospect of determining the complete sequence of the human genome seemed daunting several years ago, technical advances in DNA sequencing and bioinformatics led to the completion of a draft human sequence in June 2000, well in advance of the original goal year of 2003.
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: A BAC clone fingerprinting approach to the detection of human genome rearrangements...
In this book leading experts provide the state-of-the-art in the emerging and exciting
field of pharmacogenomics. The multitude of ways that pharmacogenomics
can be approached and applied reflects the possibilities brought about by the
wealth of data generated by the Human Genome Project, in conjunction with parallel
advances in bioinformatics and biotechnology. Procedures that are now routine
were a decade ago thought to be impossible.
Lecture Biology - Chapter 17: Genome sequencing, molecular biology, and medicine. The topics discussed in this chapter are: How do defective proteins lead to diseases? What kinds of DNA changes lead to diseases? How does genetic screening detect diseases? What is cancer? How are genetic diseases treated? What have we learned from the human genome project?
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Bench-to-bedside review: Fulfilling promises of the Human Genome Project...
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Functional constraint and small insertions and deletions in the ENCODE regions of the human genome...
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Systematic analysis of transcribed loci in ENCODE regions using RACE sequencing reveals extensive transcription in the human genome...
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: A comprehensive transcript index of the human genome generated using microarrays and computational approaches...
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Large-scale discovery and validation of functional elements in the human genome...