ETuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: lectroporation increases antitumoral efficacy of the bcl-2 antisense G3139 and chemotherapy in a human melanoma xenograft
Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : Electroporation increases antitumoral efficacy of the bcl-2 antisense G3139 and chemotherapy in a human melanoma xenograft
Lysophosphatidicacid (LPA), oneof thenaturallyoccurring
phospholipids, stimulates cellmotility through theactivation
of Rho family members, but the signaling mechanisms
remain tobe elucidated. In thepresent study,we investigated
the roles of p21-activated kinase 1 (PAK1) onLPA-induced
focal adhesion kinase (FAK) phosphorylation and cell
In chapter nineteen, Kaneda et al. develop a
hemagglutinating virus of Japan envelope (HVJ-E) vector using inactivated Sendai
virus, as a pseudovirion for gene and drug delivery. They evaluate the anti-tumor
effects of HVJ-E itself on mouse and human melanoma in animal models, and also the
enhancement of anti-tumor effects of HVJ-E containing IL-12 gene.
Gamma-retroviral vectors, commonly designated retroviral vectors, were the first viral
vector employed in Gene Therapy clinical trials in 1990 and are still one of the most used.
More recently, the interest in lentiviral vectors, derived from complex retroviruses such as
the human immunodeficiency virus (HIV), has been growing due to their ability to
transduce non-dividing cells (Lewis et al. 1992; Naldini et al. 1996), an attribute that
distinguishes them from other viral vectors, including their simple counterparts, gammaretroviral
Modern communication tools such as the Internet provide a relatively inexpensive, accessible,
easy-entry means of sharing ideas, information, and pictures around the world. In a political and
human rights context, in closed societies when the more established, formal news media is denied
access to or does not report on specified news events, the Internet has become an alternative
source of media, and sometimes a means to organize politically.
Desmoplastic melanoma (DM) is an unusual, non-pigmented, sclerosing variant of spindle
cell malignant melanoma that can range in appearance from sarcomatoid to scar-like lesion.
Cytomorphologic features described on FNA include a moderate cellularity with pleomorphic
spindle cells occurring singly and in small aggregates. The spindle cells exhibit plump
nuclei with deep grooves and folds, coarse and clumped chromatin, and inconspicuous to
multiple, prominent nucleoli, along with naked spindly nuclei. Intranuclear cytoplasmic
inclusions are rare.
From this list the information specialist sifted and removed any irrelevant material based on
the title or abstract before passing to the researcher. All the remaining articles were then
stored in a Reference Manager electronic library.
Searches were updated and re-run 6–8 weeks before the stakeholder consultation, thereby
ensuring that the latest relevant published evidence was included in the database. Any
evidence published after this date was not included.
Thea-melanocyte-stimulating hormone (aMSH) receptor
(MC1R) is amajordeterminant ofmammalianskinandhair
pigmentation. Binding ofaMSHtoMC1Rinhuman mel-anocytes stimulates cell proliferation and synthesis of pho-toprotective eumelanin pigments. Certain MC1Ralleles
have been associated with increased riskof melanoma. This
can be theoretically considered on two grounds. First, gain-of-function mutations may stimulate proliferation, thus
promoting dysplastic lesions.
Excessive inflammatory responses can be horribly destructive.
Unsurprisingly, therefore, immune responses are dampened down
and fine-tuned in a multitude of ways to minimize their damaging
effects. Four articles in this issue provide examples of such
immune regulation on four different levels.
Wolfgang Junger (page 201) explains that cells take it upon themselves
to control their behaviour to extracellular cues through autocrine feedback
loops involving purinergic receptors.
Although the psychosocial oncology literature is strong, substantial limitations and
unanswered questions remain. Much of the research has focused on heterogeneous
samples of patients who vary widely across disease site (e.g., melanoma vs. breast
cancer), stage of progression (e.g., localized vs. metastatic), and phase of illness (e.g.,
initial diagnosis vs. long-term survival). The challenges patients face vary widely across
these dimensions, and therefore, it is crucial for research designs to take this into
Toll-like receptors and RNA helicase family members [retinoic acid-inducible gene I (RIG-I) and melanoma differentiation associated gene-5
(MDA5)] play important roles in the induction of interferon-bas a major
event in innate immune responses after virus infection. TRIF (adaptor pro-tein of Toll-like receptor 3)-mediated and Cardif (adaptor protein of RIG-I
or MDA5)-mediated signaling pathways contribute rapid induction of
interferon-bthrough the activation of interferon regulatory factor-3 (IRF-3)....
A second paragraph will
address Diffuse Reflectance Spectroscopy (DRS) that has been tested on phantoms
mimicking melanoma. A third paragraph will talk about two techniques that have given
preliminary results on potential Breslow index determination: the first one, infrared
microimaging, performed on fixed and paraffin-embedded tissues (i.e. after excision of the
tumour) and the second one, photoacoustic microscopy, performed in vivo on mice on which
melanoma human cells were xenografted.
A series of alpha-substituted 2’,5’-dihydroxychalcones bearing a cyanide, bromine, or methyl group at alpha-position were synthesized and evaluated for in vitro cytotoxicity against three cancer cell lines, including B16, murine melanoma, HCT116 (colon cancer), A431 (human epidermoid carcinoma), and HUVEC (human umbilical venous endothelial cell). The synthesized chalcones showed significant cytotoxicity against most of cell lines, with IC50 values ranging from 0.97 to 10 µg/mL.
The MeOH extract of Nam ginseng (roots and rhizomes of Dracaena angustifolia) afforded two new furostanol saponins, named namonins E and F (1 and 2), along with another four known steroidal saponins (3 - 6). Their structures were determined on basis of spectral analyses and chemical methods. All compounds were tested for their antiproliferative activity against murine colon 26-L5 carcinoma, human HT-1080 fibrosar- coma and B-16 BL6 melanoma cells. Compounds 10, 11 and 14 showed potent antiprolife- rative activity against HT-1080 fibrosarcoma cells, having IC50 values of 0.2 µM, 0.