After the first edition published in 2007 that became a best seller, the continuous scientific
developments in the field have prompted us to produce the second edition of this book. As it
happens in life and science, some of the novel and promising data presented in the first edition
have been confirmed, some not, and new breakthrough achievements have been accomplished.
Stem Cells in Reproductive Medicine, Basic Science and Therapeutic Potential, second edition,
updates the revolutionary advances in stem cell science that may potentially impact on human
Stem cell research has the potential to affect the lives of millions
of people in the United States and around the world.
This research is now regularly front-page news because of the
controversy surrounding the derivation of stem cells from
human embryos. Realizing the promise of stem cells for
yielding new medical therapies will require us to grapple with
more than just scientific uncertainties. The stem cell debate
has led scientists and nonscientists alike to contemplate
profound issues, such as who we are and what makes us
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Future research and therapeutic applications of human stem cells: general, regulatory, and bioethical aspects
We are pleased to offer our committee’s report on guidelines for human embryonic
stem cell research. This report and its recommendations are the result of many
hours of committee meetings as well as a public workshop. During those sessions we
heard from many dedicated and talented people who represent a wide range of
views. We have tried to take these diverse perspectives into account in a report that
mirrors the seriousness with which we have reflected upon them.
Twenty years after the discovery of neural stem cells, the question whether the central nervous system can be considered among regenerative tissues is still open. On one side, deep characterization of neural stem and progenitor cells, their niches, and their progeny in brain neurogenic sites overtly showed that new neurons can be generated in the brain of adult mammals, including humans.
Since stem cells were first isolated from a human embryo in 1998,
interest in the development of a global stem cell market has grown
exponentially. Prior to this, while the existence of human embryonic
stem cells had long been established, it was thought impossible to
isolate them with any degree of success. The 1998 discovery opened
up a new avenue of research that subsequently became one of the
world’s hottest topics.
The specific features of the plasticity of adult stem cells are largely
unknown. Recently, we demonstrated the hepatic differentiation of human
adipose tissue-derived mesenchymal stem cells (AT-MSCs). To identify the
genes responsible for hepatic differentiation, we examined the gene expres-sion profiles of AT-MSC-derived hepatocytes (AT-MSC-Hepa) using
several microarray methods.
Therefore, ex vivo expansion of BMSCs is required to obtain a
sufficient number of transplantable cells. Since BMSCs require several kinds of supportive
factors for their growth, it is standard practice to use fetal bovine serum (FBS), while
autologous human serum (HS) and pooled allogeneic HS have also been used. It has been
suggested that FBS may not be favorable for clinical applications due to the possible risk of
contamination (prions, viruses, zoonosis) or immunological reactions against xenogeneic
serum antigens (Agata et al., 2009).
Human embryonic stem cell (hESC) lines, like those from other species, are
pluripotent cell lines derived from the inner cell mass (ICM) of the developing
embryo. Due to their exceptional capability of proliferating indefi nitely as undifferentiated
cells when cultured in appropriate conditions, and of sustaining a normal
karyotype, hESCs may have broad applications for industrial uses; clinical purposes,
namely, cell-based therapy; and research of early human development,
differentiation mechanisms, and lineage commitment.
New Concepts in the Development of Cancer Therapeutics
Cancer Stem Cells
It has long been recognized that only a small proportion of the cells within a tumor are capable of initiating colonies in vitro or of forming tumors at high efficiency when injected into immunocompromised NOD/SCID mice. Current work indicates that human acute and chronic myeloid leukemias (AML and CML) have a small population of cells (
Graft Failure While complete and sustained engraftment is usually seen posttransplant, occasionally marrow function either does not return or, after a brief period of engraftment, is lost. Graft failure after autologous transplantation can be the result of inadequate numbers of stem cells being transplanted, damage during ex vivo treatment or storage, or exposure of the patient to myelotoxic agents posttransplant. Infections with cytomegalovirus (CMV) or human herpes virus type 6 have also been associated with loss of marrow function.
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Regeneration of human bones in hip osteonecrosis and human cartilage in knee osteoarthritis with autologous adipose-tissue-derived stem cells: a case series...
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Epigenomics of human embryonic stem cells and induced pluripotent stem cells: insights into pluripotency and implications for disease
The editor has incorporated scientific contributions from a diverse group of leading
researchers in the field of hematology and related blood cell research. This book aims
to provide an overview of current knowledge pertaining to our understanding of
hematology. The main subject areas will include blood cell morphology and function,
the pathophysiology and genetics of hematological disorders and malignancies, blood
testing and typing, and the processes governing hematopoiesis. Blood cell physiology,
biochemistry and blood flow are covered in this book....
Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Effects of Expanded Human Adipose Tissue-Derived Mesenchymal Stem Cells on the Viability of Cryopreserved Fat Grafts in the Nude Mouse...
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Intratracheal transplantation of human umbilical cord blood-derived mesenchymal stem cells attenuates ...
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Therapeutic potential of human umbilical cord mesenchymal stem cells in the treatment of rheumatoid arthritis...
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: GeneChip analysis of human embryonic stem cell differentiation into hemangioblasts: an in silico dissection of mixed phenotypes...