Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Involvement of aryl hydrocarbon receptor signaling in the development of small cell lung cancer induced by HPV E6/E7 oncoproteins
Carbaryl (1-naphthyl-N-methylcarbamate), a widely used carbamate insecti-cide, induces cytochrome P450 1A gene expression in mammalian cells.
This activity is usually mediated by the interaction of the compound with
the aryl hydrocarbon receptor.
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: The aryl hydrocarbon receptor-mediated disruption of vitellogenin synthesis in the fish liver: Cross-talk between AHR- and ERα-signalling pathways...
We investigated hypoxia-inducible factor (HIF)-dependent changes in the
expression of 5592 genes in response to hypoxia (0.1% O2, 16 h) by per-forming cDNA microarray analyses of mouse hepa1c1c7 and BpRc1 cells.
BpRc1 cells are a hepa1c1c7 variant defective in HIF-b⁄aryl hydrocarbon
receptor nuclear translocator (Arnt), and are therefore unable to induce
HIF target genes in response to hypoxia.
Ligand binding by the aryl hydrocarbon receptor (AhR), a
member of the bHLH-PAS family of transcriptional reg-ulatory proteins, has been mapped to a region within the
second ÔPASÕ domain, a conserved sequence motif ®rst
discovered in the Per-ARNT-Sim family of proteins.
The aromatic hydrocarbon receptor (AhR)-dependent pathway involved
in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced immunotoxicity
has been studied extensively, but the AhR-independent molecular mechan-ism has not. In previous studies we found that the AhR is not expressed
in L-MAT, a human lymphoblastic T-cell line. In this report, we provide
the following evidence that the protein kinase C (PKC)hactivity is func-tionally involved in the AhR-independent signal transduction mechanism
that participates in the TCDD-induced L-MAT cell apoptosis....
Reactions and transformations of chemicals. Many chemicals undergo reaction or
transformation in the subsurface environment. In contrast to retardation contaminants may be
removed, rather than simply slowed down. Reactions of harmful chemicals to yield benign
products prior to arrival at a receptor are the ideal, e.g. many toxic hydrocarbons have
potential to biodegrade to simple organic acids (of low health concern and themselves
potentially degradable), carbon dioxide (bicarbonate) and water. Transformation often causes
a deactivation (lowering) of toxicity.