The peptide hormones of the anterior pituitary are essential for the regulation of growth and
development, reproduction, responses to stress, and intermediary metabolism. Their synthesis and
secretion are controlled by hypothalamic hormones and by hormones from the peripheral endocrine
organs. A large number of disease states as well as a diverse group of drugs also affect their
This book is part of a two-part program focused on the broad theme of “biochemistry
and fine-tuning.” Fitness of the Cosmos for Life began with a symposium
held at Harvard University in October 20031 in honor of the 90th anniversary of
the publication of Lawrence J. Henderson’s The Fitness of the Environment.2 The
symposium was an interdisciplinary, exploratory research meeting of scientists and
other scholars that served as a stimulus for the creative thinking process used in
developing the content of this book.
The smooth functioning of the money market depends critically on brokers and
dealers, who play a key role in marketing new issues of money market instruments and in providing
secondary markets where outstanding issues can be sold prior to maturity. Dealers use RPs to finance their
inventories of securities. Dealers also act as intermediaries between other participants in the RP market by
making loans to those wishing to borrow in the market and borrowing from those wishing to lend in the
Brokers match buyers and sellers of money market instruments on...
Approach to the Patient: Anemia The evaluation of the patient with anemia requires a careful history and physical examination. Nutritional history related to drugs or alcohol intake and family history of anemia should always be assessed. Certain geographic backgrounds and ethnic origins are associated with an increased likelihood of an inherited disorder of the hemoglobin molecule or intermediary metabolism.
The pyruvate dehydrogenase complex occupies a central and strategic posi-tion in muscle intermediary metabolism and is primarily regulated by phos-phorylation⁄dephosphorylation. The identification of multiple isoforms of
pyruvate dehydrogenase kinase (PDK1–4) and pyruvate dehydrogenase
phosphatase (PDP1–2) has raised intriguing new possibilities for chronic
pyruvate dehydrogenase complex control.