Imatinib has also demonstrated targeted activity in other diseases, including gastrointestinal stromal tumors (GIST), rare mesenchymal tumors of the GI tract (stomach and small intestine). The pathogenic molecular event for most patients with this disease is mutation of the proto-oncogene c-Kit, leading to the constitutive activation of this receptor tyrosine kinase without the binding of its physiologic ligand, stem cell factor. About 10% of GISTs encode activating mutations of the PDGFRα instead of c-Kit.
Normalization of tumor blood vessels due to inhibition of VEGF signaling.
A. Blood vessels in normal tissues exhibit a regular hierarchical branching pattern that delivers blood to tissues in a spatially and temporally efficient manner to meet the metabolic needs of the tissue (top). At the microscopic level, tight junctions are maintained between endothelial cells (EC), which are adherent to a thick and evenly distributed basement membrane (BM). Pericytes form a surrounding layer that provides trophic signals to the EC and helps maintain proper vessel tone.
Prostate cancer is one of the most common types of cancer in men and its treatment was constricted to surgery for confined state and androgen ablation for advanced disease until new options have become available. The present book covers a broad range of novel aspects of prostate cancer diagnosis, treatment and patient care, as well as new research on relevant cell biology.
I-band That zone of the sarcomere composed of actin alone. I-cells (CNID) The interstitial cells. ichnotaxon n. [Gr. ichnos, track; taxis, arrangement] A taxon based on fossilized impressions, tracks, trails, and burrows made by an animal, but not part of that animal.
Hirschsprung’s disease is one of the most important and
most fascinating diseases in paediatric surgery. Our understanding
of Hirschsprung’s disease is developing rapidly,
not only in relation to its pathophysiology and the
development of new surgical techniques, but especially
in relation to new genetic findings.
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: Differential cell reaction upon Toll-like receptor 4 and 9 activation in human alveolar and lung interstitial macrophages...
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:"Biochemical and morphological changes in endothelial cells in response to hypoxic interstitial edema...
FELLOWS OF THE ASSOCIATION: In the endeavor to chronicle the lives and achievements of Kentucky
Pioneers in Surgery, I shall not attempt the resurrection of village Hampdens or mute inglorious Miltons. The
men with whom I deal were men of deeds, not men of fruitless promise.
It may with truth be said that from Hippocrates to Gross few in our profession who have done enduring work
have lacked biographers to pay liberal tribute to their worth. In justice to the unremembered few, I turn back
the records of medicine for a century, and put my finger upon two names that in the bustling march of...
The regulation of adenosine kinase (AK) activity has the
potential to control intracellular and interstitial adenosine
(Ado) concentrations. In an effort to study the role of AK in
Ado homeostasis in the central nervous system, two iso-forms of the enzymewere cloned fromamouse brain cDNA
library. Following overexpression in bacterial cells, the cor-responding proteins were purified to homogeneity.
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Probing the mystery of Chinese medicine meridian channels with special emphasis on the connective tissue interstitial fluid system, mechanotransduction, cells durotaxis and mast cell degranulation...
Although group IIA secretory phospholipase A2 (sPLA2-IIA) is known to
be abundantly present in the joints of patients with rheumatoid arthritis
(RA), expression of other sPLA2
s in this disease has remained unknown.
In this study, we examined the expression and localization of six sPLA2s
(groups IIA, IID, IIE, IIF, V and X) in human RA.