Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:Nicotine enhances murine airway contractile responses to kinin receptor agonists via activation of JNK- and PDE4-related intracellular pathways...
This book spans a variety of approaches to address the complex problem of Alzheimer´s
disease - what is the cause, is there a single pathogenetic pathways or are there many of
them, how can we address the whole clinical spectrum of the disease, how can the disease
be diagnosed early and reliable and which perspectives we have for prevention and treat‐
ment. The collection covers actual topics of interest for basic researcher, clinicians, epidemi‐
ologists and provides insight...
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Hyperoxic acute lung injury and ventilator-induced/associated lung injury: new insights into intracellular signaling pathways...
This book, with its 16 chapters, documents the present state of knowledge of the
adenosine A3 receptor. It covers a wide range of information, including data from
studies of theoretical, molecular and cellular pharmacology, signal transduction,
integrative physiology, new drug discoveries and clinical applications. It fills an
important gap in the literature since no alternative source of such information is
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: A pathway sensor for genome-wide screens of intracellular proteolytic cleavage...
Somatostatin receptor (SSTR) endocytosis influences cellular responsiveness
to agonist stimulation and somatostatin receptor scintigraphy, a common
diagnostic imaging technique. Recently, we have shown that SSTR1 is dif-ferentially regulated in the endocytic and recycling pathway of pancreatic
cells after agonist stimulation.
Following up on our previous findings that the skin pos-sesses steroidogenic activity from progesterone, we now
show widespread cutaneous expression of the full cyto-chrome P450 side-chain cleavage (P450scc) system required
for the intracellular catalytic production of pregnenolone,
i.e. the genes andproteins for P450scc enzyme, adrenodoxin,
adrenodoxin reductase and MLN64. Functionality of the
system was confirmed in mitochondria from skin cells.
The leptin receptor (LEPR) is a class I cytokine receptor signalling via
both the janus kinase⁄signal transducer and activator of transcription
(JAK⁄STAT) and the MAP kinase pathways. In addition, leptin has been
shown previously to activate AMP-activated kinase (AMPK) in skeletal
muscle. To enable a detailed analysis of leptin signalling in pancreatic beta
cells, LEPR point mutants with single or combined exchanges of the three
intracellular tyrosines were expressed in HIT-T15 insulinoma cells....
Autophagy and apoptosis have been known to be interconnected positively
or negatively; however, the molecular mechanisms mediating these two cel-lular processes are not fully understood. In the present study, we demon-strated that the exposure of L929 cells to oridonin led to intracellular
reactive oxygen species generation, followed by lipid peroxidation, as well
as decreases in superoxide dismutase and glutathione activities.
Chloride intracellular channels (CLICs) are soluble, signal peptide-less pro-teins that are distantly related to W-type glutathione-S-transferases.
Although some CLICs bypass the classical secretory pathway and auto-insert into cell membranes to form ion channels, their cellular roles remain
Several protein toxins, such as the potent plant toxin ricin, enter mamma-lian cells by endocytosis and undergo retrograde transport via the Golgi
complex to reach the endoplasmic reticulum (ER). In this compartment the
catalytic moieties exploit the ER-associated degradation (ERAD) pathway
to reach their cytosolic targets. Bacterial toxins such as cholera toxin or
Pseudomonasexotoxin A carry KDEL or KDEL-like C-terminal tetrapep-tides for efficient delivery to the ER.
The vacuolar H
-ATPase (V-ATPase) is a multimeric
enzyme complex that acidi®es organelles of the vacuolar
system in eukaryotic cells. Proteins that interact with the
V-ATPase may play an important role in controlling the
intracellular localization and activity of the proton pump.
The neuroendocrine-enriched V-ATPase accessory subunit
Ac45 may represent such a protein as it has been shown to
interactwith themembrane sector of theV-ATPase inonlya
subset of organelles.
In human neutrophils, both changes in intracellular Ca
, and activation of phosphatidyl-inositol-3 kinase (PtdIns3K) have been proposed to play a
role in regulating cellular function induced by chemoattr-actants. In this studywe have investigated the role of [Ca
and its effector molecule calmodulin in human neutrophils.
(BQ) Part 1 book "Elsevier's integrated review biochemistry" presents the following contents: Acid-Base concepts, structure and properties of biologic molecules, protein structure and function, enzymes and energetics, membranes and intracellular signal transduction, glycolysis and pyruvate oxidation, minor carbohydrate pathways,...
Enzymes that function within plants, animals, and microorganisms are fundamental to
life, and their contributions to metabolic pathways and processes have been studied extensively.
For over 100 years there has been interest in what today is called ecological or
environmental enzymology. This aspect of enzymology originates from the work of
Woods, who, in 1899, wrote about the survival and function in soil of plant peroxidases
following their release from decaying plant roots.
At the beginning of the 21st century, medicine is increasingly
based on understanding the functions of genes and the molecular
mechanisms of diseases. In pancreatology, the understanding
of functions and dysfunctions of the exocrine and
endocrine pancreas is derived from molecular biological data
on the actions of compounds in subcellular compartments and
intracellular transcription pathways.
Methionine (Met) is an essential amino acid and the only sub-strate for synthesis of S-adenosylmethionine (AdoMet) that is the
main substrate for multiple intracellular methylases. There are
two modes of Met metabolism in liver. In case of its dietary
restriction Met can be metabolized via conservative remethylation
cycle. In case of Met excess (high [Met]) it is mostly converted to
cysteine via transsulfuration pathway.
The Nbs1 protein associates with Mre11 and Rad50 proteins to form the
Mre11–Rad50–Nbs1 complex, which plays an important role in the
intracellular signaling pathway activated in response to DNA damage.
Mutations in the genes for each of these three components of the Mre11–
Rad50–Nbs1 complex result in human diseases characterized by genomic
Connective tissue growth factor (CTGF/CCN2) is an
immediate early gene-encoded polypeptide modulating cell
growth and collagen synthesis. The importance of CTGF/
CCN2 function is highlighted by its disregulation in fibrotic
disorders. In this study, we investigated the regulation and
signaling pathways that are required for various stimuli of
intracellular signaling events to induce the expression of the
endogenous CTGF/CCN2gene in smooth muscle cells.
Although the role of arachidonic acid (AA) in the regulation
of steroidogenesis is well documented, the mechanism for
AArelease isnot clear.Therefore, theaimof this studywas to
characterize the role of an acyl-CoA thioesterase (ARTISt)
and an acyl-CoA synthetase as members of an alternative
pathway in the regulation of the intracellular levels of AA in
steroidogenesis. Purified recombinant ARTISt releases AA
from arachidonoyl-CoA (AA-CoA) with a Kmof 2lM.