Conversation between two people is usually of MIXED-INITIATIVE, with CONTROL over the conversation being transferred from one person to another. We apply a set of rules for the transfer of control to 4 sets of dialogues consisting of a total of 1862 turns. The application of the control rules lets us derive domain-independent discourse structures. The derived structures indicate that initiative plays a role in the structuring of discourse.
This work is the first systematic investigation of initiative in human-human tutorial dialogue. We studied initiative management in two dialogue strategies: didactic tutoring and Socratic tutoring. We hypothesized that didactic tutoring would be mostly tutor-initiative while Socratic tutoring would be mixedinitiative, and that more student initiative would lead to more learning (i.e., task success for the tutor).
This chapter explains the methods used in conducting an effective follow-up investigation. In addition to existing internal and external reports and documents, neighborhood and vehicle canvasses in the immediate vicinity of the crime are essential. For various reasons, witnesses and other parties who may have valuable information do not always initiate contact with the police.
Tools to Investigate Improvement Opportunities.
We have discussed the assessment, plotting, and analysis of both PD and PP maturity level data. We know how to target those knowledge areas that should be further investigated for improvement opportunities. We have suggested a few approaches for ranking improvement opportunities. In this chapter we look under the hood at a knowledge area or individual process within a knowledge area to analyze the PD or PP performance to define potential areas for improvement initiatives.
To derive our empirical results, we obtain a sample of equity SRI funds from the Social
Investment Forum for the period 1997-2005 and merge this sample with the CRSP Survivor
Bias Free US Mutual Fund Database. Our results indicate that the SRI constraint does not
reduce funds' before-fee performance, measured using the four-factor alpha of Carhart (1997).
On the contrary, SRI funds outperform comparable conventional funds by a substantial 0.96% to
1.83% per year before expenses.
The collection of data milling damage in the two provinces for more than three mills
each province (Kien Giang and Tien Giang) were made in 2007-2008. Undertaking
the recovery of rice will not only depend on the initial quality of rice (existing cracks or
major cereals), but also on the effectiveness of the milling operation. So, in this work, the fact
milling loss of data is collected in two provinces of Tien Giang and Kien Giang. There exist three
system of rice plants in both provinces:
The past thirty years have witnessed the birth, growth, and evolution of clinical electrophysiology from a field whose initial goals were the understanding of arrhythmia
mechanisms to one of significant therapeutic impact. The development and refinement of implantable devices and catheter ablation have made non-pharmacologic
therapy a treatment of choice for most arrhythmias encountered in clinical practice.
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: The sensory feedback mechanisms enabling couples to walk synchronously: An initial investigation
Federal agencies in Germany are required to fully implement IT-Grundschutz according to the
specifications of the Federal Implementation Plan. In addition to being required to create and
implement a security concept, they are also required to follow the specifications in BSI standards
100-1 [BSI1] and 100-2 [BSI2] as well as to check the success of their implementation through IS
audits. In order to maintain and continuously improve information security.
Three protein factors IF1, IF2 and IF3 are involved in the
initiation of translation in prokaryotes. No clear function
has been assigned to the smallest of these three factors, IF1.
Therefore, to investigate the role of this protein in the initi-ation process inEscherichia coliwe have mutated the cor-responding gene infA. Because IF1 is essential for cell
viability and no mutant selection has so far been described,
the infA gene in a plasmid was mutated by site-directed
mutagenesis in a strain with a chromosomalinfA
The aim of the present study was to investigate in detail the molecular mecha-nisms by which free fatty acids induce liver toxicity in liver cells. HepG2 and
Huh7 human liver cell lines were exposed to varying concentrations of stea-rate (18:0), oleate (18:1), or mixtures of the two fatty acids, and the effects on
cell proliferation, lipid droplet accumulation and induction of endoplasmic
reticulum stress and apoptosis were evaluated.
In recent years, the National Science Foundation (NSF) has been work
ing to develop closer links between the funding of scientific research
and increasing public understanding of science. Its efforts to improve
public understanding of science have focused on schools, colleges, and universities
but have included support for museums, aquariums, and other
programs. Those efforts are designed to prepare future scientists and educators,
as well as to inform the public about how science affects society....
In response to a request by the Lucille P. Markey Charitable Trust, the
National Research Council (NRC) of the National Academies, through
the Board on Higher Education and Workforce (BHEW), is conducting
an evaluation of the Markey Trust’s grant programs in the biomedical
sciences. During an interval of 15 years, the Markey Trust spent more
than $500 million on four programs in the basic biomedical sciences that
support the education and research of graduate students, postdoctoral
fellows, junior faculty, and senior researchers.
The soluble guanylyl cyclases (sGC), the receptor for nitric oxide, are hete-rodimers consisting of ana- and b-subunit. This study aimed to investigate
the translational mechanism of the sGC b2-subunit. Two mRNA species
for sGC b2 were isolated from human kidney.
ABCG2 confers resistance to cancer cells by mediating the ATP-dependent
outward efflux of chemotherapeutic compounds. Recent studies have indi-cated that the protein contains a number of interconnected drug binding
sites. The present investigation examines the coupling of drug binding to
The catalytic reaction mechanism and binding of substrates was investi-gated for the multisubstrateDrosophila melanogasterdeoxyribonucleoside
kinase. Mutation of E52 to D, Q and H plus mutations of R105 to K and
H were performed to investigate the proposed catalytic reaction mech-anism, in which E52 acts as an initiating base and R105 is thought to sta-bilize the transition state of the reaction.
Fairly large proportion of patients attending
for the first time the Chest Clinics in India have
had anti-tuberculosis chemotherapy for some
time though irregularly. The assessment of the
prevalence of Initial Drug Resistance (IDR)
among these patients will be of great value in
their management and also in formulating
general policies of treatment in the Chest
Clinics under the National Tuberculosis Control
In searching for new targets for antimalarials we investigated the biosyn-thesis of hypusine present in eukaryotic initiation factor-5A (eIF-5A) in
Plasmodium. Here, we describe the cloning and expression of deoxyhypu-sine hydroxylase (DOHH), which completes the modification of eIF-5A
through hydroxylation of deoxyhypusine.
We examined whether the fast release of replicon initiation after sudden O2
recovery of hypoxically incubated mammalian cells depends on kinase
activity of Cdk2. We used a system based on starved⁄refed T24 cells elab-orated previously for such investigations [van Betteraey-Nikoleit M, Eisele
KH, Stabenow D & Probst H (2003)Eur J Biochem270, 3880–3890].