Xem 1-14 trên 14 kết quả Kidney drugs
  • Description: Identifies drug products approved on the basis of safety and effectiveness by the Food and Drug Administration under the Federal Food, Drug, and Cosmetic Act.

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  • The publication Approved Drug Products with Therapeutic Equivalence Evaluations (the List, commonly known as the Orange Book) identifies drug products approved on the basis of safety and effectiveness by the Food and Drug Administration (FDA) under the Federal Food, Drug, and Cosmetic Act (the Act). (For more information, see the Orange Book Preface.)

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  • Hypertension and Chronic Kidney Disease: Cause and Consequence – Therapeutic Considerations 45 Elsa Morgado and Pedro Leão Neves Potassium-Sparing Diuretics in Hypertension 67 Cristiana Catena, GianLuca Colussi and Leonardo A. Sechi Hypertension and Renin-Angiotensin System Roberto de Barros Silva Pharmacokinetic Interactions of Antihypertensive Drugs with Citrus Juices 95 Yoshihiro Uesawa Drug Interaction

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  • The kidneys comprise only 0.5% of body weight, yet they receive 25% of the cardiac output. Drugs that affect renal function have important roles in cardiac failure and hypertension. Disease of the kidney must be taken into account when prescribing drugs that are eliminated by it. Diuretic drugs: their sites and modes of action, classification, adverse effects and uses in cardiac, hepatic, renal and other conditions. Carbonic anhydrase inhibitors. Cation-exchange resins and their uses. Alteration of urine pH Drugs and the kidney. Adverse effects.

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  • Diuretics increase the rate of urine flow and sodium excretion and are used to adjust the volume and/or composition of body fluids in a variety of clinical situations, including hypertension, heart failure, renal failure, nephrotic syndrome, and cirrhosis. The objective of this chapter is to provide the reader with unifying concepts as to how the kidney operates and how diuretics modify renal function. The chapter begins with a description of renal anatomy and physiology, as this information is prerequisite to a discussion of diuretic pharmacology....

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  • Following their lipophilicity, it is more plausible that vitamin E and ß-carotene cooperate to protect membranes and lipoproteins from oxidative damages. Of course, as all antioxidants, vitamin E exerts other biological functions that are independent from its antioxidant properties, including modulation of cellular signaling, gene expression, immune response, and many more. However, as opposed to other vitamins, lack of vitamin E results in rather unspecific symptoms, also highlighting that this vitamin is mainly needed for its antioxidant activity in vivo.

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  • Metabolomics (or metabonomics) is metabolite profil- ing, measuring the real outcome of the potential changes suggested by genomics and proteomics. Metabolomics investigates regulation and metabolic fluxes in individual cells or cell types. Metabonomics combines the power of high-resolution nuclear magnetic resonance with statistical data analysis of in vivo metabolite patterns. This technique enables rapid screening for xenobiotic toxicity, disease state, drug efficiency, nutritional status and even gene function in the “whole” organism. (Nicholson et al., 2002).

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Clinical review: Drug metabolism and nonrenal clearance in acute kidney injury...

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  • The most important treatment of acute rheumatic fever is prevention, associated with improvements in socioeconomic conditions. Once acute rheumatic fever has occurred, treatment includes penicillin to eradicate the streptococcal infection, high dose aspirin as an anti-inflammatory drug, or steroids if the cardiac disease is severe. Heart failure is treated with diuretics, and urgent heart valve replacement may occasionally be required.

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  • In spite of remarkable progress in drug therapy, childhood and adolescent epilepsy is often a distressing condition lasting several years before possible recovery. Adaptation problems to the disease and also to health recovery are likely to occur. Stigma and discrimination may persist also after recovery. 11,12 Depression in children and adolescents with epilepsy is a common but often unrecognized disorder. Both epilepsy and depression are characterized by a chronic course and poor long- term psychosocial outcome.

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  • Congenital abnormalities of the kidney and urinary tract are reported to occur in 5 to 10% of the population [9]. They represent 25% of the total ultrasonographically diagnosed malformations that occur in 0.25–0.7% of fetuses. About 1/3 to 2/3 of ESRD in children are due to congenital ab- normalities of the kidney and urinary tract. In addition, these abnormalities occur in 23% of patients with chromosomal aberrations, and 2/3 of patients with abnormalities of other organ systems.

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  • This handbook emphasizes the use of synthetic membranes for separations involving industrial or municipal process streams. Little will be said concerning the use of membranes in medical applications as in artificial kidneys or for controlled drug release. Most of the membrane processes are pressure driven. The notable exception to this is electrodialysis (ED) by which ions are separated under the influence of an electric field. In addition, the chapter on coupled transport covers processes which are driven under the influence of a concentration gradient....

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  • Renal Disease Renal excretion of parent drug and metabolites is generally accomplished by glomerular filtration and by specific drug transporters, only now being identified. If a drug or its metabolites are primarily excreted through the kidneys and increased drug levels are associated with adverse effects, drug dosages must be reduced in patients with renal dysfunction to avoid toxicity. The antiarrhythmics dofetilide and sotalol undergo predominant renal excretion and carry a risk of QT prolongation and arrhythmias if doses are not reduced in renal disease.

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  • Evaluation of the patient with jaundice. MRCP, magnetic resonance cholangiopancreatography; ALT, alanine aminotransferase; AST, aspartate aminotransferase; SMA, smooth-muscle antibody; AMA, antimitochondrial antibody; LKM, liver-kidney microsomal antibody; SPEP, serum protein electrophoresis; CMV, cytomegalovirus; EBV, Epstein-Barr virus. Isolated Elevation of Serum Bilirubin Unconjugated Hyperbilirubinemia The differential diagnosis of an isolated unconjugated hyperbilirubinemia is limited (Table 43-1).

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