Klinefelter syndrome

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  • The preparation of human karyotype for the first time in 1959 led to the identification of numerical aberrations in the following years associated with Down’s, Turner and Klinefelter syndromes which implied the need for routine screening for chromosomal anomalies in certain clinical conditions.

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  • American men face a staggering array of health concerns. According to the Centers for Disease Control and Prevention, 70 percent of American men are overweight, a key predictor of future health problems. Almost 25 percent smoke, another key risk factor. One in five American men has heart disease, and 29 percent aged twenty and older suffer from hypertension. More than 11 percent of men face a limitation in their usual activities due to chronic health conditions. In addition, the medical concerns men face often differ from those of most concern to women.

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  • Table 105-5 Diseases or Exposures Associated with Increased Risk of Development of Malignant Lymphoma Inherited immunodeficiency disease Klinefelter's syndrome Chédiak-Higashi syndrome Ataxia telangiectasia syndrome Wiscott-Aldrich syndrome Common variable immunodeficiency disease Acquired immunodeficiency diseases Iatrogenic immunosuppression HIV-1 infection Acquired hypogammaglobulinemia Autoimmune disease Sjögren's syndrome Celiac sprue Rheumatoid arthritis and systemic lupus erythematosus Chemical or drug exposures Phenytoin Dioxin, phenoxyherbicides Radiation P...

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