Lumen formation

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  • During development, cells and tissues undergo dynamic changes in pattern and form that employ a wider range of physical mechanisms than at any other time during an organism’s life. Biological Physics of the Developing Embryo presents a framework within which physics can be used to analyze these biological phenomena. Written to be accessible to both biologists and physicists, major stages and components of biological development are introduced and then analyzed from the viewpoint of physics. The presentation of physical models requires no mathematics beyond basic calculus.

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  • Surfactant protein C (SP-C) constitutes the transmembrane part of prosurf-actant protein C (proSP-C) and isa-helical in its native state. The C-termi-nal part of proSP-C (CTC) is localized in the endoplasmic reticulum lumen and binds to misfolded (b-strand) SP-C, thereby preventing its aggregation and amyloid fibril formation.

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  • The urachus is an embryological canal connecting the urinary bladder of the fetus with the allantois, a structure that contributes to the formation of the umbilical cord. The lumen (inside) of the urachus is normally obliterated during embryonic development, transforming the urachus into a solid cord, a functionless remnant. The urachus lies in the space of Retzius, between the transversalis fascia anteriorly and the peritoneum posteriorly.

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