Lysophosphatidylcholine

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  • Phospholipids are known to influence fibril formation of amyloid beta (Ab) peptide. Here, we show that lysophosphatidylcholine (LPC), a polar phos-pholipid, enhances Ab(1-42) fibril formation, by decreasing the lag time and the critical peptide concentration required for fibril formation, and increasing the fibril elongation rate.

    pdf9p mobifone23 07-01-2013 15 3   Download

  • Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Product inhibition of secreted phospholipase A2 may explain lysophosphatidylcholines' unexpected therapeutic properties...

    pdf10p thulanh27 13-12-2011 12 2   Download

  • Lysophosphatidylcholine induces expression of adhesion molecules; how-ever, the underlying molecular mechanisms of this are not well elucidated. In this study, the intracellular signaling by which lysophosphatidylcholine upregulates vascular cell adhesion molecule-1 and P-selectin was delineated using YPEN-1 and HEK293T cells.

    pdf12p galaxyss3 21-03-2013 12 2   Download

  • Mononuclear phagocytes play a pivotal role in the pro-gression of septic shock by producing tumor necrosis factor-a(TNF-a) andother inflammatorymediators in response to lipopolysaccharide (LPS) fromGram-negativebacteria.Our previous studies have shown monocyte and macrophage activationcorrelatewithchanges inmembranephospholipid composition, mediated by acyltransferases. Interferon-c (IFN-c), which activates and primes these cells for enhanced inflammatory responses to LPS, was found to selectively activate lysophosphatidylcholine acyltransferase (LPCAT) (P...

    pdf7p fptmusic 16-04-2013 12 1   Download

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