Xem 1-20 trên 38 kết quả Malignant breast
  • Noninvasive Breast Cancer Breast cancer develops as a series of molecular changes in the epithelial cells that lead to ever more malignant behavior. Increased use of mammography has led to more frequent diagnosis of noninvasive breast cancer. These lesions fall into two groups: ductal carcinoma in situ (DCIS) and lobular carcinoma in situ (lobular neoplasia). The management of both entities is controversial. Ductal Carcinoma In Situ (DCIS) Proliferation of cytologically malignant breast epithelial cells within the ducts is termed DCIS.

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  • Chemotherapy Unlike many other epithelial malignancies, breast cancer responds to multiple chemotherapeutic agents, including anthracyclines, alkylating agents, taxanes, and antimetabolites. Multiple combinations of these agents have been found to improve response rates somewhat, but they have had little effect on duration of response or survival. The choice among multidrug combinations frequently depends on whether adjuvant chemotherapy was administered and, if so, what type.

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  • In spite of the massive efforts being made worldwide to understand molecular genetics and epigenetic factors responsible for the initiation and progression of cancer, the statistics on this malignancy have remained enormously negative; the following data testify to this unfortunate human condition. There are more than 100 types of cancers that can inflict any part of the body. In 2005, 7.6 million people died of cancer, which makes up 13% of the 58 million deaths worldwide. Approximately 1.

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  • Harrison's Internal Medicine Chapter 86. Breast Cancer Breast Cancer: Introduction Breast cancer is a malignant proliferation of epithelial cells lining the ducts or lobules of the breast. In the year 2007, about 180,510 cases of invasive breast cancer and 40,910 deaths occurred in the United States. Epithelial malignancies of the breast are the most common cause of cancer in women (excluding skin cancer), accounting for about one-third of all cancer in women.

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  • If a nonpalpable mammographic lesion has a low index of suspicion, mammographic follow-up in 3–6 months is reasonable. Workup of indeterminate and suspicious lesions has been rendered more complex by the advent of stereotactic biopsies. Morrow and colleagues have suggested that these procedures are indicated for lesions that require biopsy but are likely to be benign—that is, for cases in which the procedure probably will eliminate additional surgery. When a lesion is more probably malignant, open biopsy should be performed with a needle localization technique.

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  • Rare patients with localized early stage mycosis fungoides can be cured with radiotherapy, often total-skin electron beam irradiation. More advanced disease has been treated with topical glucocorticoids, topical nitrogen mustard, phototherapy, psoralen with ultraviolet A (PUVA), electron beam radiation, interferon, antibodies, fusion toxins, and systemic cytotoxic therapy. Unfortunately, these treatments are palliative. Adult T Cell Lymphoma/Leukemia Adult T cell lymphoma/leukemia is one manifestation of infection by the HTLV-I retrovirus.

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  • Average annual age-adjusted cancer incidence rates were calculated for each poverty area group in New Jersey. Included in the report are the average annual age-adjusted incidence rates per 100,000 population for all types of cancer combined and 16 cancers that are the most common types among men and/or women, or among the leading causes of cancer death.

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  • A definitive summary of novel techniques, this 1st volume in the New Technologies Series details the most current and multidisciplinary approach to new technologies used in general plastic, hand, peripheral nerve, microsurgery, breast, esthetic, and trauma surgery and provides an overview of the most important and clinically relevant plastic surgery research. New surgical images of new surgical approaches are all accompanied with anatomical descriptions.

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  • The potential value of artificial neural networks (ANNs) as a predictor of malignancy has now been widely recognised. The concept of ANNs dates back to the early part of the 20th century; however, their latest resurrection started in earnest in the 1980s when they were applied to many problems in the areas of pattern recognition, control, and optimisation.

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  • It has been said that the control of disease has three goals, which, in increasing order of attraction are palliation, cure, and prevention. For most types of disseminated cancer, medical science has achieved only the first of these objectives, while for some malignancies the side effects of the therapeutic agents employed rival the disease itself in precluding a desirable quality of life.

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  • Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Toxoplasmosis presenting as a swelling in the axillary tail of the breast and a palpable axillary lymph node mimicking malignancy: a case report...

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  • Breast cancer is a malignant proliferation of epithelial cells lining the ducts or lobules of the breast. In the year 2007, about 180,510 cases of invasive breast cancer and 40,910 deaths occurred in the United States. Epithelial malignancies of the breast are the most common cause of cancer in women (excluding skin cancer), accounting for about one-third of all cancer in women.

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  • The tactile examination of the breast is best performed with the patient re- cumbent with her arm raised above her head. A small pillow under her upper back can further distribute the breast tissue over the chest wall. Palpation is performed using the base of the fingertips in small circular motions with vari- able depth. Recall that breast tissue extends beyond the region usually defined by a bra cup.

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  • In Mozambique, Pathfinder is going beyond traditional maternal and child health to ensure the survival of children into adulthood. In addition to their traditional role distributing family planning information and products, CHWs have begun distributing water-purification solution and insecticide-treated bed nets for malaria prevention to pregnant women and mothers of children under five. They are promoting exclusive breast-feeding to the age of six-months, iron and folate supplements for pregnant women, growth monitoring, deworming, and proper nutrition.

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  • Glutamate carboxypeptidase III (GCPIII) is a metalloenzyme that belongs to the transferrin receptor⁄glutamate carboxypeptidase II (GCPII; EC superfamily. GCPIII has been studied mainly because of its evo-lutionary relationship to GCPII, an enzyme involved in a variety of neuro-pathologies and malignancies, such as glutamatergic neurotoxicity and prostate cancer.

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  • Abstract Dermatofibrosarcoma protuberans is an uncommon locally aggressive malignant neoplasm that most frequently appears in the trunk, followed by the extremities, head, and neck. But occurrence in the breast is extremely rare. We present a case of a 28-year-old woman, who had a history of trauma 5 years previously and excision 1 year before presentation at our clinic. We performed wide excision, together with microscopic and immunohistochemical analysis. No postoperative oncologic treatment was used and she remains disease-free 1 year after the surgery without any tumor recurrence.

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Radio-induced malignancies after breast cancer postoperative radiotherapy in patients with Li-Fraumeni syndrome...

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  • Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Successfully treated synchronous double malignancy of the breast and esophagus: a case report...

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  • Steroid hormone receptors are important drug targets and have been the focus of basic and applied research for decades. Steroid hormone receptors act as ligand-dependent transcription factors. Upon ligand binding, the receptors bind to hormone responsive cis-acting DNA elements (HREs) in the nucleus and regulate the expression of target genes by recruiting chromatin-modifying activities that either promote or deny access to the basal transcription machinery.

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  • Licensing origins for replication upon completion of mitosis ensures genomic stability in cycling cells. Cdt1 was recently discovered as an essential licensing factor, which is inhibited by geminin. Over-expression of Cdt1 was shown to predis-pose cells for malignant transformation. We show here that Cdt1 is down-regulated at both the protein and RNA level when primary human fibroblasts exit the cell cycle into G0, and its expression is induced as cells re-enter the cell cycle, prior to S phase onset. ...

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