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Homologous recombination (HR) serves to eliminate deleterious
lesions, such as double-stranded breaks and interstrand crosslinks,
from chromosomes. HR is also critical for the preservation of replication
forks, for telomere maintenance, and chromosome segregation
in meiosis I. As such, HR is indispensable for the maintenance
of genome integrity and the avoidance of cancers in humans. The
HR reaction is mediated by a conserved class of enzymes termed
For a long time, research on developmental issues in the biological and
social sciences was mostly concerned with the early parts of life, such as
infancy and adolescence. Studies paying full attention to people after they
had passed through late adolescence were rare even though we all know
that humans continue to develop. The dynamics of adult life can be as
forceful and full of transitory states as is life before 20. Individual
development is a lifelong process: from the moment of conception to the
moment of death.
Intact mitochondria isolated from Nicotiana tabacumcv. Bright Yellow 2
(TBY-2) cells can take up riboflavin via carrier-mediated systems that oper-ate at different concentration ranges and have different uptake efficiencies.
Once inside mitochondria, riboflavin is converted into catalytically active
cofactors, FMN and FAD, due to the existence of a mitochondrial ribofla-vin kinase (EC 188.8.131.52) and an FAD synthetase (EC 184.108.40.206).
Human disc-large (hDlg) is a scaffold protein critical for the maintenance
of cell polarity and adhesion. hDlg is a component of the p38c MAP
kinase pathway, which is important for the adaptation of mammalian cells
to changes in environmental osmolarity.
As one class of the most important steroid hormones, glucocorticoids have long been recognised and their therapeutic benefits have been widely used in clinical treatment, especially in anti-inflammation cases.
The vitamins are a chemically disparate group of compounds whose only common
feature is that they are dietary essentials that are required in small amounts for the
normal functioning of the body and maintenance of metabolic integrity.Metabolically,
they have diverse functions, such as coenzymes, hormones, antioxidants,
mediators of cell signaling, and regulators of cell and tissue growth and differentiation.
The lung has a unique vascular structure and function; it has low pressure, low
resistance circulation with a highly compliant system which accommodates the same
amount of flow as the systemic circulation. In addition, pulmonary and systemic
vasculatures have divergent responses to various stimuli. For example, pulmonary
arteries constrict in the setting of hypoxia, while systemic circulation dilates. This is
due to distinctive developmental characteristics, anatomic and histological structure,
as well as physiological properties.
Multiple Variants Modulating Drug Effects As this discussion makes clear, for each drug with a defined mechanism of action and disposition pathways, a set of "candidate genes," in which polymorphisms may mediate variable clinical responses, can be identified. Indeed, polymorphisms in multiple genes have been associated with variability in the effect of a single drug. CYP2C9 loss-of-function variants are associated with a requirement for lower maintenance doses of the vitamin K antagonist anticoagulant warfarin. In rarer (...
Extent of knowledge sharing: Related to the above problem is the question of how much knowledge is available
to the system during its query optimization process. In particular, the ﬁrst step in choosing a query evaluation strategy
is likely to be identifying which nodes have materialized views that can speed query processing. A simple technique
would be to use a centralized catalog of all available views and their locations, analogous to the central directory used
by Napster. Yet this model introduces a single point of failure and a potential scalability bottleneck.
he tumor suppressor, breast cancer susceptibility gene 1 (BRCA1), plays
an integral role in the maintenance of genome stability and, in particular,
the cellular response to DNA damage. Here, the emerging role of BRCA1
in nonhomologous end-joining-mediated DNA repair following DNA dam-age will be reviewed, as well as the activation of apoptotic pathways.
Protein–lipid interactions are important for protein targeting, signal trans-duction, lipid transport, and the maintenance of cellular compartments
and membranes. Specific lipid-binding protein domains, such as PH,
FYVE, PX, PHD, C2 and SEC14 homology domains, mediate interactions
between proteins and specific phospholipids.