(BQ) Part 1 book "Gastrointestinal pathology and its clinical implications" presents the following contents: Dialogue, biopsies–taking and handling, resected specimens; protocols; vascular disorders and related diseases, immunodeficiency disorders, disorders of endocrine cells, motility disorders, mesenchymal tumors,...
(BQ) Part 2 book "Dermatology acne" presentation of content: The Vasculopathic pattern, panniculitis, fibrosing dermatitis, the depositional pattern, the melanocytic tumors, epithelial neoplasms, adnexal neoplasms, the mesenchymal tumors.
The specific features of the plasticity of adult stem cells are largely
unknown. Recently, we demonstrated the hepatic differentiation of human
adipose tissue-derived mesenchymal stem cells (AT-MSCs). To identify the
genes responsible for hepatic differentiation, we examined the gene expres-sion profiles of AT-MSC-derived hepatocytes (AT-MSC-Hepa) using
several microarray methods.
(BQ) Part 2 book "Practical soft tissue pathology - A diagnostic approach" presentation of content: Biphasic tumors and tumors with mixed patterns, adipocytic tumors, vascular tumors, cartilaginous and osseous soft tissue tumors, cutaneous mesenchymal tumors, mesenchymal tumors of the gastrointestinal tract, lower genital soft tissue tumors, applications of molecular testing to differential diagnosis,...
Cancer may constitute the most extensively studied
disease entity of our time. Nevertheless, our comprehension
of the cellular and molecular pathology
of malignant transformation is incomplete. In view
of the diverse clinical presentations of various
malignancies, doubts may be raised as to whether it
is appropriate to refer to cancer as one group of disease
states. The notion of malignant tumors as a
pathologic and pathophysiologic class of conditions
begs the question for defining criteria that characterize
all malignant growths, regardless of their tissue
U mô đệm đường tiêu hóa (GIST: gastrointestinal stromal tumor, u mô đệm) là loại u thường gặp nhất trong các loại u trung mô (mesenchymal tumor) đường tiêu hóa, chiếm tỷ lệ khoảng 1-3% tất cả các u ác tính đường tiêu hóa, với tỷ lệ 6-20 trên 1 triệu dân số(1,2). Hầu hết u phát xuất từ dạ dày (60%), kế tiếp là từ ruột non (30%), và hiếm hơn ở thực quản và đại tràng
Imatinib has also demonstrated targeted activity in other diseases, including gastrointestinal stromal tumors (GIST), rare mesenchymal tumors of the GI tract (stomach and small intestine). The pathogenic molecular event for most patients with this disease is mutation of the proto-oncogene c-Kit, leading to the constitutive activation of this receptor tyrosine kinase without the binding of its physiologic ligand, stem cell factor. About 10% of GISTs encode activating mutations of the PDGFRα instead of c-Kit.
Tumor-Induced Hypoglycemia Caused by Excess Production of IGF-II (See also Chap. 339) Mesenchymal tumors, hemangiopericytomas, hepatocellular tumors, adrenal carcinomas, and a variety of other large tumors have been reported to produce excessive amounts of insulin-like growth factor type II (IGF-II) precursor, which binds weakly to insulin receptors and strongly to IGF-I receptors, leading to insulin-like actions. The gene encoding IGF-II resides on a chromosome 11p15 locus that is normally imprinted (that is, expression is exclusively from a single parental allele).
For decades, endocytosis has been recognized as a fundamental cellular process that
regulates the uptake of small molecules (cell surface proteins, bacteria, toxins, etc.) into
the cell. So why, after years of study, does this simple process warrant more
discussion? Anyone who has examined the endocytic pathway will appreciate that this
conceptually simple mechanism is highly complex and sophisticated. Like ballet
dancers who make their synchronous performance seem effortless, the cell brings in
molecules via a carefully choreographed mechanism.
(BQ) Part 2 book "Liver pathology" presentation of content: Liver allograft pathology, liver involvement in other systemic diseases, benign epithelial nodules and tumors, malignant epithelial tumors, vascular tumors, tumors with mesenchymal component.
(BQ) Part 1 book "Pathology of the maxillofacial bones - A guide to diagnosis" presentation of content: Non-neoplastic diseases, cysts, epithelial odontogenic tumors, odontogenic tumors mesenchymal, odontogenic tumors - mixed epithelial and mesenchymal, odontogenic tumors - malignant.
Other Nonmelanoma Cutaneous Malignancies
Neoplasms of cutaneous adnexa and sarcomas of fibrous, mesenchymal, fatty, and vascular tissues make up 1–2% of NMSC (Table 83-6). Some can portend a poor prognosis such as Merkel cell carcinoma, which is a neural crestderived, highly aggressive malignancy that exhibits a metastatic rate of 75% and a 5-year survival rate of 30–40%. Others, such as the human herpes virus 8-induced, HIV-related Kaposi's sarcoma, exhibit a more indolent course.
Oncogene signaling pathways are activated during tumor progression and promote metastatic potential.
This figure shows a cancer cell that has undergone epithelial to mesenchymal transition (EMT) under the influence of several environmental signals. Critical components include activated transforming growth factor beta (TGF-β) and the hepatocyte growth factor (HGF)/c-Met pathways, as well as changes in the expression of adhesion molecules that mediate cell-cell and cellextracellular matrix interactions.