Metabolic theory

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  • The discovery of a new drug is a challenging task that includes (a) identifica- tion of a biochemical target for certain diseases and (b) screening of a large number of compounds from libraries of compounds arising from synthetic chemistry, combinatorial chemistry, and natural product isolation for lead gen- eration. The lead compound is then optimized based on biological activity, selectivity, pharmacokinetic property, and metabolism.

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  • Great efficiencies have been achieved in the drug discovery process as a result of technological advances in target identification, high-throughput screening, high-throughput organic synthesis, just-in-time in vitro ADME (absorption, distribution, metabolism, and excretion), and early pharmacokinetic screening of drug leads. These advances, spanning target selection all the way through to clinical candidate selection, have placed greater and greater demands on the analytical community to develop robust high-throughput methods.

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  • Recent advances in mass spectrometry have rendered it an attractive and versatile tool in industrial and academic research laboratories. As a part of this rapid growth, a considerable body of literature has been devoted to the application of mass spectrometry in clinical studies. In concert with separation techniques such as liquid chromatography, mass spectrometry allows the rapid characterization and quantitative determination of a large array of molecules in complex mixtures.

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  • More than ten years ago, two of us (AGH and DGR) were lucky enough to edit a previous symposium of the British Ecological Society (BES) – Aquatic Ecology: Scale, Pattern and Process (Giller, Hildrew & Raffaelli, 1994). In the Introduction to that volume, we pointed out that the BES had not devoted a single previous symposium to aquatic ecosystems.

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  • Like money, power and empires, economic theory and practice have a short half-life. Joan Robinson remarks: “It has generally been the fate of economics to run a losing race against the course of history, and never to have completed the analysis of one phase of economic development before another takes its place.” 57 She was speaking of the discipline, of course. Like other disciplines, economics is incarnate in human flesh, contrary to public rumour. Whether, with Keynes, in the long run economists are all dead, their dogmas die seasonally, like flies.

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  • The classical metabolic control theory [Kacser, H. & Burns, J.A. (1973)Symp.Soc.Exp.Biol. 27, 65–104; Heinrich, R. & Rapoport, T. (1974)Eur. J. Biochem.42, 89–95.] does not take into account experimental evidence for correlations between enzyme concentrations in the cell. We investigated the implications of two causes of linear correlations: competition between enzymes, which is a mere physical adaptation of the cell to the limitation of resources and space, and regulatory correlations, which result from the existence of regulatory networks....

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  • When was the last time you did something really special just for you? If you’re like a lot of nurses, the answer might be, “I can’t remember!” I wrote Fit Nurse: Your Total Plan for Getting Fit and Living Well with the goal of changing that answer to, “I do something special for myself every day !” This book will help you rise above the many challenges and struggles you face as a nurse when it comes to your own self-care, fitness, nutrition, weight management, stress management, and well-being.

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