Our understanding of the importance of noncoding RNA molecules is steadily growing. One such important
class of RNA molecules are microRNAs (miRNAs). These tiny RNAs fulfi ll important functions in cellular
behavior by infl uencing the protein output levels of a high variety of genes through the regulation of
target messenger RNAs. Moreover, miRNAs have been implicated in a wide range of diseases. In pathological
conditions, the miRNA expression levels can be altered due to changes in the transcriptional or
posttranscriptional regulation of miRNA expression.
Many recent studies have reported that microRNA (miRNA) biogenesis
and function are related to the molecular mechanisms of various clinical
diseases. Several methods, including northern blotting and DNA chip anal-yses, are capable of assessing miRNA-production patterns in cells. How-ever, the development of repetitive monitoring of the miRNA-production
profile in a noninvasive manner is demanded for the application of
miRNAs to human medicine.
RNomics is a newly emerging sub-discipline of genomics that categorically
studies the structure, function and processes of non-coding ribo nucleic acids in
a cell. MicroRNomics is a sub-field of RNomics that describes the biogenesis and
mechanisms of tiny RNA regulators, and their involvement in the processes of
development, differentiation, cell proliferation, cell death, chromosomal segregation
and metabolism. The discovery of microRNAs in species ranging from
Caenorhabditis elegans (C.
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Vive la différence: biogenesis and evolution of microRNAs in plants and animals...