Our understanding of the importance of noncoding RNA molecules is steadily growing. One such important
class of RNA molecules are microRNAs (miRNAs). These tiny RNAs fulfi ll important functions in cellular
behavior by infl uencing the protein output levels of a high variety of genes through the regulation of
target messenger RNAs. Moreover, miRNAs have been implicated in a wide range of diseases. In pathological
conditions, the miRNA expression levels can be altered due to changes in the transcriptional or
posttranscriptional regulation of miRNA expression.
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Differentiation associated regulation of microRNA expression in vivo in human CD8+ T cell subsets
MicroRNAs (miRNAs) are small noncoding RNAs (~22 nucleotides) that regulate gene expression by cleaving mRNAs or inhibiting translation. The baboon is a well-characterized cardiovascular disease model; however, no baboon miRNAs have been identified. Evidence indicates that the baboon and human genomes are highly conserved; based on this conservation, we hypothesized that comparative genomic methods could be used to identify baboon miRNAs.
MicroRNAs (miRNAs) regulate gene expression post-transcriptionally by
binding to target mRNAs in a sequence-specific manner. A large number
of genes appear to be the target of miRNAs, and an essential role for
miRNAs in the regulation of various conserved cell signaling cascades,
such as mitogen-activated protein kinase, Notch and Hedgehog
MicroRNAs (miRNAs) comprise species of short noncoding RNA that
regulate gene expression post-transcriptionally. Recent studies have demon-strated that epigenetic mechanisms, including DNA methylation and his-tone modification, not only regulate the expression of protein-encoding
genes, but also miRNAs, such as let-7a, miR-9, miR-34a, miR-124, miR-137, miR-148 and miR-203.
MicroRNAs (miRNAs) are a class of small noncoding RNAs that have
gained status as important regulators of gene expression. Recent studies
have demonstrated that miRNAs are aberrantly expressed in the cardiovas-cular system under some pathological conditions.
RNomics is a newly emerging sub-discipline of genomics that categorically
studies the structure, function and processes of non-coding ribo nucleic acids in
a cell. MicroRNomics is a sub-field of RNomics that describes the biogenesis and
mechanisms of tiny RNA regulators, and their involvement in the processes of
development, differentiation, cell proliferation, cell death, chromosomal segregation
and metabolism. The discovery of microRNAs in species ranging from
Caenorhabditis elegans (C.
Non coding endogenous RNAs were first discovered in the last decade of the previous
century. These new discoveries changed our views of the transcriptome landscape of
plant genomes and paradigms of the regulation of gene expression. With the beginning
of this century, we have witnessed an explosion of studies on small regulatory
RNAs that has yielded a basic understanding of the many types of small RNAs in
diverse eukaryotic species and how they are functioning as RNA–protein complexes
along the RNA silencing pathways.
important regulators of biological processes in animals
and plants. MiRNAs regulate gene expression at
the posttranscriptional level by binding to mRNAs and
either inhibit translation or modify the stability of the
mRNA. Due to the important biological role of miRNAs
it is of great interest to study their expression level in
the cells. Furthermore, miRNAs have been associated
with cancer and other diseases  and miRNA expression
can help in the diagnosis and prognostic of human
Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Regulation of microRNA biosynthesis and expression in 2102Ep embryonal carcinoma stem cells is mirrored in ovarian serous adenocarcinoma patients
MicroRNAs are a class of small noncoding RNAs that function as key reg-ulators of gene expression at the post-transcriptional level. Recently, micr-oRNA-373 (miR-373) has been found to function as an oncogene in
testicular germ cell tumors.
MicroRNA mir-9 is speculated to be involved in insulin secretion because
of its ability to regulate exocytosis. Sirt1 is an NAD-dependent protein
deacetylase and a critical factor in the modulation of cellular responses to
altered metabolic flux. It has also been shown recently to control insulin
secretion from pancreaticb-islets.
It is increasingly clear that microRNAs (miRNAs) play an important role
in many diseases, including tumorigenesis. However, the mechanisms by
which miRNAs regulate bladder cancer development remain poorly under-stood.
MicroRNAs are aberrantly expressed in cancer; microRNA-143 (miR-143)
is down-regulated in colon cancer. HCT116 human colorectal cancer cells
were used to investigate the biological role of miR-143. Transient miR-143 overexpression resulted in an approximate 60% reduction in cell via-bility.
MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene
expression by inhibiting translation and⁄or inducing degradation of target
mRNAs, and they play important roles in a wide variety of biological func-tions including cell differentiation, tumorigenesis, apoptosis and metabo-lism.