Our understanding of the importance of noncoding RNA molecules is steadily growing. One such important
class of RNA molecules are microRNAs (miRNAs). These tiny RNAs fulfi ll important functions in cellular
behavior by infl uencing the protein output levels of a high variety of genes through the regulation of
target messenger RNAs. Moreover, miRNAs have been implicated in a wide range of diseases. In pathological
conditions, the miRNA expression levels can be altered due to changes in the transcriptional or
posttranscriptional regulation of miRNA expression.
MicroRNAs (miRNAs) are a class of small noncoding RNAs that have
gained status as important regulators of gene expression. Recent studies
have demonstrated that miRNAs are aberrantly expressed in the cardiovas-cular system under some pathological conditions.
MicroRNAs (miRNAs) are small noncoding RNAs (~22 nucleotides) that regulate gene expression by cleaving mRNAs or inhibiting translation. The baboon is a well-characterized cardiovascular disease model; however, no baboon miRNAs have been identified. Evidence indicates that the baboon and human genomes are highly conserved; based on this conservation, we hypothesized that comparative genomic methods could be used to identify baboon miRNAs.
RNomics is a newly emerging sub-discipline of genomics that categorically
studies the structure, function and processes of non-coding ribo nucleic acids in
a cell. MicroRNomics is a sub-field of RNomics that describes the biogenesis and
mechanisms of tiny RNA regulators, and their involvement in the processes of
development, differentiation, cell proliferation, cell death, chromosomal segregation
and metabolism. The discovery of microRNAs in species ranging from
Caenorhabditis elegans (C.
important regulators of biological processes in animals
and plants. MiRNAs regulate gene expression at
the posttranscriptional level by binding to mRNAs and
either inhibit translation or modify the stability of the
mRNA. Due to the important biological role of miRNAs
it is of great interest to study their expression level in
the cells. Furthermore, miRNAs have been associated
with cancer and other diseases  and miRNA expression
can help in the diagnosis and prognostic of human
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" MicroRNAs in inflammatory lung disease - master regulators or target practice?...
It is increasingly clear that microRNAs (miRNAs) play an important role
in many diseases, including tumorigenesis. However, the mechanisms by
which miRNAs regulate bladder cancer development remain poorly under-stood.
Many recent studies have reported that microRNA (miRNA) biogenesis
and function are related to the molecular mechanisms of various clinical
diseases. Several methods, including northern blotting and DNA chip anal-yses, are capable of assessing miRNA-production patterns in cells. How-ever, the development of repetitive monitoring of the miRNA-production
profile in a noninvasive manner is demanded for the application of
miRNAs to human medicine.
Breast cancer (BC), the most common type of cancer among women worldwide, is a polygenetic disease which is caused by the interaction of several genes. Understanding the genetic factors for early diagnosis of BC is crucial to ensure the survival of BC patients. MicroRNA 27a (miR-27a), an oncogenic miRNA, has been predicted to target on the tumor suppressor ZBTB10 that can regulate many processes of cell.