Milk evolved as a means of providing for the postnatal needs of the developing
mammalian neonate. Any perception that milk is a simple, homogeneous fluid does
not adequately acknowledge the remarkable array of complex activities and
functionalities of its constituent components.
The large intestine of breast-fed infants is colonized
predominantly by bi®dobacteria, which have a protective
eect against acute diarrhea. In this study we report for the
®rst time the identi®cation of human milk peptides that
selectively stimulate the growth of bi®dobacteria. Several
pepsin-treated human milk and identi®ed as proteolytically
generated fragments from the secretory component of the
soluble polyimmunoglobulin receptor and lactoferrin;...
The present work reports isolation and characterization of a highly glycosylated protein from bovine milk fat globule membranes, known as PAS III. Partial amino-acid sequencing of the puriﬁed protein allowed construction of degenerate oligonucleotide primers, enabling isolation of a full-length cDNA encoding a protein of 330 amino-acid residues. N-terminal amino-acid sequencing of derived peptides and the puriﬁed protein conﬁrmed 76% of the sequence and demonstrated presence of a cleavable signal peptide of 23 residues, leaving a mature protein of 307 amino acids.