Mitochondrial defects

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  • The process likely begins with the development of defects in the supply of cholesterol and fats to neurons, progressing to extensive oxidative damage, mitochondrial defects, and a shift of metabolism towards utilizing sources other than glucose and minimizing mito- chondrial involvement. In the end stage, neurons can no longer transmit signals effectively, and apoptosis is the best option to avoid damaging neighboring cells. A crucial role is played by astrocytes, the glial cells that supply cholesterol and fats to neurons.

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  • Content marketing is all the rage. In a distracted world, where consumers are bombarded with advertising and overwhelmed by media and device choices, brands are searching for a new ways to connect—ideally over the long term. And many marketers are turning to content with varying degrees of success.

    pdf21p mokahd 27-04-2013 39 25   Download

  • The ability of privately insured individuals to obtain faster access to care is significantly influenced by governmental policies and approaches. Allowing public providers to treat both private and public patients and to receive different remuneration levels for these separate activities can encourage their involvement in the private sector. This spurs the development of a market for PHI products offering access to more timely elective care in the private sector.

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  • While the structure of the dairy processing industry has improved dramatically, milk collection and distribution is fragmented compared to systems found in other countries. There is a need to improve the supply chain from farmer to consumer in Pakistan. There is very limited data available on the routes to market or the distribution channels employed in Pakistan. Most of the milk produced in the farms is consumed at the household level.

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  • Despite the prominence of gender issues in the IADGs, effectiveness of development cooperation has not focussed enough on outcomes of gender equality and women’s rights in terms of either the inclusion of indicators tracking the focus of development cooperation on gender equality or the participation of women’s organisations in initiatives to hold actors to account. 2012 analysis conducted for the DCF shows that aid/partnership policies, targets and mutual accountability processes do not focus adequately on the gender impact of development cooperation.

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  • B2B Content Marketing: 2012 Benchmarks, Budgets and Trends is the second annual survey about content marketing in the business-to-business (B2B) space. We surveyed 1,092 marketers from diverse industries and a wide range of company sizes in August 2011. Last year, the results revealed content marketing is a well-established, core marketing strategy in the B2B marketplace. However, while many marketers were using these tactics, they were uncertain about their effectiveness.

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  • This document is copyrighted by the NFPA. It is made available for a wide variety of both public and private uses. These include both use, by reference, in laws and regulations, and use in private self-regulation, standardization, and the promotion of safe practices and methods. By making this document available for use and adoption by public authorities and private users, the NFPA does not waive any rights in copyright to this document. Use of NFPA documents for regulatory purposes should be accomplished through adop- tion by reference.

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  • Competitiveness, as measured by the SBSI, relates strongly to the ability of a small business to succeed in meeting broad business goals. Owners of businesses in the “highly competitive” category largely believe they have successful businesses; for example, the businesses are growing, creating wealth, avoiding risk, and meeting the owners’ expectations for income and an attractive lifestyle.

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  • Evidence of increasing age includes wrinkles and sagging skin. Aging skin appears thinner, more pale, and clear (translucent). Thus, skin is at higher risk for injury. Large pigmented spots (called age spots, liver spots, or lentigos) may appear in sun-exposed areas. The blood vessels of the skin become more fragile. This leads to bruising, bleeding under the skin. Women’s skin gradually produces less oil beginning after menopause. This can make it harder to keep the skin moist, resulting in dryness and itchiness. The sweat glands produce less sweat.

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  • Another trend to be examined in the depiction of female characters is the clear dichotomy which is followed. The woman is docile, domestic, honourable, noble, and ideal or she is the other extreme – wayward, reckless and irresponsible. Why does Bollywood shy away from taking the middle path? Where are women who are good or bad as per the situation they face in their lives? Where are the women who negotiate with troubles on a daily basis and emerge victorious? In David Dhawan‟s Biwi no.1 (1999), the wife played by Karishma Kapoor is shown to have sacrificed...

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  • If your route can be organised as a predominantly self-guided walk this means you don’t need so many marshals or signs. This reduces the cost, time and effort spent putting up signs. However, large, mass- participation events do need highly visible marshals and may well need signs placed at strategic points to keep people on the right route. If you want to put up signs you’ll need to get approval from the local authority. If the route is mostly self-guided everyone should be given a clear map.

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  • Cropproductioninthepasthasfocusedmainlyonreducedinputsprovidedperkgofeconomic product,however,inabiobasedeconomy,newparadigmsareemerging.Netenergybalanceis one feature thathas to taken intoaccount forsustainableproductionsystems.Furthermore, comparing the environmental impact of processes and products is necessary, as they are criteria for selecting the most sustainable option.

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  • Encouraging country ownership and strengthening health systems: Ultimately, governments – together with non- governmental organizations (NGOs), civil society organizations (CSOs) including affected communities, faith-based organizations (FBOs), the private sector and others in countries – must decide upon their countries’ health needs and strategies. They are responsible for making and sustaining progress, and they must be accountable to those served by their health systems.

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  • Several sexuality education programs have been evaluated, and many include a combination of abstinence messages for sexually inexperienced teens and messages about contraceptive use for sexually experienced teens. Slightly more than half of these programs show some positive impacts on reproductive health outcomes for at least some populations (Aarons et al., 2000; Eisen, Zellman & McAlister, 1990; Kirby, 2001; Thomas et al., 1992).

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  • In both countries, the early years of transition were associated with fiscal decentralization. In each of the transition economies, fiscal decentralization was a central piece of economic policy reform, for, as reforming economies became more decentralized and market-based, the public finances became the primary instrument for supplying public goods, protecting vulnerable members of society, and maintaining growth and stability. Yet, while fiscal decentralization fostered rapid growth in China, in Russia, de facto fiscal decentralization had dire consequences.

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  • Applying much more phosphorus fertilizer and manure than crops can use builds up phosphorus in soil. After continuous over-fertilization, agricultural fields become a persistent reservoir for phosphorus that ends up polluting water bodies. Recent USGS study found that in the agricultural Midwest, many streams have their highest nitrogen concentrations in the spring, peaking in April-May.

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  • The average cost to bring to market a so-called block-buster drug is currently estimated at $895 million (EFPIA, 2002). Obviously firms who spend that kind of money need to recoup their costs. Furthermore industry analysts point out that Big Pharma under pressure. It needs to expand sales of blockbuster drugs since there are fewer drugs in pipeline. In order to sustain current levels of growth, firms would need to introduce one new product each year that would sell $4.9 million for each 1 to 1.5 per cent it has of the world pharmaceutical market. “A company the size of the...

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  • In Istanbul, the business and financial services sectors form the major source of demand, with letting activity being mainly con- centrated on the European side, where more office space exists. The city’s modern Central Business District (CBD) is stretched on a ‘strip’ on the European side that crosses two separate boroughs and includes the areas of Levent, Esentepe, Zincirlikuyu and Maslak. The high quality office buildings (Class A) are mainly found in Levent and Maslak.

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  • Another challenge that may present an issue for a venture capital fund or private equity fund under the Exchange Act is the requirement that any U.S. issuer (for our purposes, any U.S. fund) that has more than 499 holders of record or any non-U.S. issuer (non-U.S. fund) that has more than 299 holders of record resident in the United States comply with public disclosure, reporting, and other obligations as a public company under the Exchange Act. As a result, great care is taken to ensure that these limits are not exceeded.

    pdf17p quaivattim 04-12-2012 29 4   Download

  • A complete screening medical examination for tuberculosis consists of a medical history, physical examination, chest radiography (CXR, when required), determination of immune response to Mycobacterium tuberculosis antigens (i.e., tuberculin skin testing [TST] or interferon gamma release assay [IGRA], when required), and sputum testing for M. tuberculosis (when required, Figures 1 and 2). Applicants ≥15 years of age require a medical history, physical examination, and CXR.

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