Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Effects of prolonged endotoxemia on liver, skeletal muscle and kidney mitochondrial function...
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Transient expression of bC1 protein differentially regulates host genes related to stress response, chloroplast and mitochondrial functions
Mitochondria are dynamic organelles that undergo continual fusion and
fission to maintain their morphology and functions, but the mechanism
involved is still not clear. Here, we investigated the effect of mitochondrial
oxidative stress triggered by high-fluence low-power laser irradiation (HF-LPLI) on mitochondrial dynamics in human lung adenocarcinoma cells
(ASTC-a-1) and African green monkey SV40-transformed kidney fibroblast
We investigated the changes in the oxidative stress response of yeast cells
suffering mitochondrial dysfunction that could impair their viability.
First, we demonstrated that cells with this dysfunction rely exclusively on
cytosolic thioredoxin peroxidase I (cTPxI) and its reductant sulfiredoxin,
among other antioxidant enzymes tested, to protect them against H2O2
Mitochondrial functional and structural impairment and generation of oxidative stress have been implicated in aging, various diseases and chemotherapies. This study analyzed azidothymidine (AZT)-caused failures in mitochondrial functions, in redox regulation and activation of the HIV-1 gene expression. We monitored intracellular concentrations of ATP and glutathione (GSH) as the indicators of energy production and redox conditions, respectively, during the time-course experiments with U937 and MOLT4 human lymphoid cells in the presence of AZT (0.05 mgÆmL)1) or H2O2 (0.
Calcium is an extraordinarily versatile signaling ion, encoding cellular
responses to a wide variety of external stimuli. In neurons, mitochondria
can accumulate enormous amounts of calcium, with the consequence that
mitochondrial calcium uptake, sequestration and release play pivotal roles
in orchestrating calcium-dependent responses as diverse as gene transcrip-tion and cell death.
There is an ongoing debate on the presence of beneficial effects of mino-cycline (MC), a tetracycline-like antibiotic, on the preservation of mito-chondrial functions under conditions promoting mitochondria-mediated
Aging is accompanied by gradual cellular dysfunction associated with an
accumulation of damaged proteins, particularly via oxidative processes.
This cellular dysfunction has been attributed, at least in part, to impair-ment of mitochondrial function as this organelle is both a major source of
oxidants and a target for their damaging effects, which can result in a
reduction of energy production, thereby compromising cell function.
To examine whether valinomycin induces a mitochondrial
permeability transition (PT), we investigated its effects on
mitochondrial functions under various conditions. The
acceleration of mitochondrial respiration and swelling,
induced by valinomycin, were found to be insensitive to
inhibitors of the ordinary PT, indicating that valinomycin
does not induce the ordinary PT. Results of experiments
usingmitochondria isolated fromtransgenicmice expressing
human bcl-2 also supported this conclusion.
The increased level of reactive oxygen species (ROS) in living organisms over 60 years
ago was implicated in the development of diseases and aging (Harman, 1956; 1983).
This book is a collective scientific monograph presenting several important aspects
related to ROS role in human and animal pathologies. In 1985, German scientist
Helmut Sies first denoted oxidative stress concept, which immediately attracted
attention of researchers in diverse basic fields. Several discoveries substantially
stimulated the interest to ROS as ones related to many diseases.
The existence of an inducible mitochondrial nitric oxide synthase has been
recently related to the nitrosative⁄oxidative damage and mitochondrial dys-function that occurs during endotoxemia. Melatonin inhibits both inducible
nitric oxide synthase and inducible mitochondrial nitric oxide synthase
activities, a finding related to the antiseptic properties of the indoleamine.
Inhibition of the mitochondrial adenine nucleotide translocator (ANT) by
long-chain acyl-CoA esters has been proposed to contribute to cellular dys-function in obesity and type 2 diabetes by increasing formation of reactive
oxygen species and adenosine via effects on the coenzyme Q redox state,
mitochondrial membrane potential (Dw) and cytosolic ATP concentrations.
Mutational analysis of functional domains in Mrs2p, the mitochondrial Mg2+ chanThe nuclear geneMRS2in Saccharomyces cerevisiaeencodes an integral
protein (Mrs2p) of the inner mitochondrial membrane. It forms an ion
channel mediating influx of Mg
into mitochondria. Orthologues of
Mrs2p have been shown to exist in other lower eukaryotes, in vertebrates
and in plants.nel protein of Saccharomyces cerevisiae
` Julian Weghuber, Frank Dieterich, Elisabeth M. Froschauer, Sona Svidova and Rudolf J. Schweyen
Sco proteins are present in all types of organisms, including the vast major-ity of eukaryotes and many prokaryotes. It is well established that Sco pro-teins in eukaryotes are involved in the assembly of the CuAcofactor of
mitochondrial cytochromecoxidase; however their precise role in this pro-cess has not yet been elucidated at the molecular level.
Mitochondrial biogenesis, which depends on nuclear as well as mitochon-drial genes, occurs in response to increased cellular ATP demand. The
nuclear transcriptional factors, estrogen-related receptor a (ERRa) and
nuclear respiratory factors 1 and 2, are associated with the coordination of
the transcriptional machinery governing mitochondrial biogenesis
The mitochondrial carriers are a family of transport proteins that shuttle
metabolites, nucleotides and cofactors across the inner mitochondrial mem-brane. The genome ofDrosophila melanogasterencodes at least 46 mem-bers of this family. Only five of these have been characterized, whereas the
transport functions of the remainder cannot be assessed with certainty.
Mood disorders are a crucial group of mental disorders that last for a life time, cause psychosocial dysfunction, disrupts interpersonal relationships and are overall highly restrictive. The facts that mood disorders are seen as high as 3-5% of the society and 70% of the patients' first psychiatric application puts forward that they are not well known show that these are a serious type of mental illness. The average time to make the right diagnose is reported as 10 years.
Mitochondria, which are the cellular energy plants, also act as the integra-tion center of cellular signaling pathways. Apoptosis is a well-known
pathway in which mitochondria are involved. Protein kinase Cehas been
classified as a novel type of protein kinase C and is involved in many
cellular events regulating mitochondrial function.