The existence of an inducible mitochondrial nitric oxide synthase has been
recently related to the nitrosative⁄oxidative damage and mitochondrial dys-function that occurs during endotoxemia. Melatonin inhibits both inducible
nitric oxide synthase and inducible mitochondrial nitric oxide synthase
activities, a finding related to the antiseptic properties of the indoleamine.
In the synthesis of ammonia, under industrial conditions, the
reaction normally comes sufficiently close to equilibrium for the
applications of thermodynamics to prove of immense value. t Thus
it will predict the influence of changes of pressure, temperature and
composition on the maximum attainable yield. By contrast in the
catalytic oxidation of ammonia the yield of nitric oxide is determined,
not by the opposition of forward and backward reactions, as in
ammonia synthesis, but by the relative speeds of two independent
processes which compete with each other for the available ammonia.
With parallel breakthroughs occurring in molecular biology and nanoscience/technology, the newly
recognized research thrust on “nanomedicine” is expected to have a revolutionary impact on the
future of healthcare. To advance nanotechnology research for cancer prevention, diagnosis, and
treatment, the United States National Cancer Institute (NCI) established the Alliance for
Nanotechnology in Cancer in September 2004 and has pledged $144.3 million in the next five years
(for details, visit http://nano.cancer.gov).