This book pilots the reader into the future. The first three chapters introduce new materials and material processing methods. Then five chapters present innovative new design directions and solutions. The main section of the book contains ten chapters organized around problems and methods of manufacturing and technology, from cutting process optimisation through maintenance and control to the Digital Factory. The last two chapters deal with information and energy, as the foundations of a prospering economy....
Various bacterial protein toxins and effectors target the actin cytoskeleton.
At least three groups of toxins⁄effectors can be identified, which directly
modify actin molecules. One group of toxins⁄effectors causes ADP-ribosy-lation of actin at arginine-177, thereby inhibiting actin polymerization.
Freeform fabrication technology does not
require pre-formed mandrels or tooling;
instead, it builds physical objects directly
from computer graphical data. This type of
technology is also known as layer
manufacturing, since it constructs the three-
dimensional object layer by layer (Jacobs,
1992; Beaman et al., 1997). The technology
has proved that it can help to rapidly provide
feedback on design concepts, discover
inconsistencies in the design, modify the
design, and eliminate inconsistency before
fabricating the design.