Molecular architecture

Xem 1-20 trên 22 kết quả Molecular architecture
  • A unique 30-residue cationic peptide oxyopinin 4a (Oxt 4a) was identified in the venom of the lynx spider Oxyopes takobius(Oxyopidae). Oxt 4a con-tains a single N-terminally located disulfide bond, Cys4–Cys10, and is structurally different from any spider toxin studied so far.

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  • Tools shape how we think; when the only tool you have is an axe, everything resembles a tree or a log. The rapid advances in instrumentation in the last decade, which allow us to measure and manipulate individual molecules and structures on the nanoscale, have caused a paradigm shift in the way we view molecular behavior and surfaces. The microscopic details underlying interfacial phenomena have customarily been inferred from in situ measurements of macroscopic quantities. Now we can see and “finger” physical and chemical processes at interfaces.

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  • The transient receptor potential channel vanilloid receptor subunit 1 (TRPV1) is amolecular integrator of physical and chemical stimuli in the peripheral nociceptor terminals. TRPV1 is an ionotropic channel that plays a critical role in both thermal nociception and inflammatoryhyperalgesia. Structure–function relationships are providing fundamental insights of the modular architecture of this neuronal recep-tor.

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  • Next, a few words about our strategy. It is well recognized now that one has to go beyond the Einstein-Hilbert action for gravity, both from the experimental viewpoint (eg.,because of Dark Energy) and from the theoretical viewpoint (eg., because of the UV incompleteness of quantized Einstein gravity, and the need of its unification with the Standard Model of Elementary Particles). In our approach, the origin of inflation is purely geometrical, ie. is closely related to space-time and gravity.

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  • We believe that it is interesting to study the system and software architecture of environments which integrate the evolving ideas of computational grids, distributed objects, web services, peer-to-peer networks and message oriented middleware. Such peer-to-peer (P2P) Grids should seamlessly integrate users to themselves and to resources which are also linked to each other. We can abstract such environments as a distributed system of “clients” which consist either of “users” or “resources” or proxies thereto.

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  • In gravity injection, small volumes of reagents are gravity-fed into injection well(s) over a longer application period. The distribution and dissipation of the reagents in the saturated zone is largely controlled by the site hydrogeologic conditions. The gravity injection approach may reduce some of risks associated with chemical oxidation technologies. Additionally, given its prolonged application period, the oxidants may be able to penetrate into more of the lower permeability soils to address contaminants in these areas.

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  • Volume 4 delves into our interconnected, networked society. The Internet is explored in detail, including its history, applications, and backbone. Molecular computing and artificial life are discussed, as are mobile computing and encryption technology. The reader will find articles on electronic banking, books, commerce, publishing, as well as information access and overload. Ethical matters pertaining to the electronic universe are also addressed. Volume 4 extends our aesthetic interest with articles on photography and the use of computers in art.

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  • A seminal idea proposed in The Intimate Enemy which has subsequently come rather to define Nandy's (frequently mis-represented) public political stance concerns the disjunctions imposed by colonialism which have returned to haunt contemporary India. The pen- etration of the West has created a class of mimic men, "modernists, whose attempts to identify with the colo- nial aggressors has produced...pathetic copies of...

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  • Nanoelectronics is a rapidly expanding field with researchers exploring a very large number of innovative techniques for constructing devices intended to implement high-speed logic or high-density memory. Less common, however, is work intended to examine how to utilize such devices in the construction of a complete computer system. As devices become smaller, it becomes possible to construct ever more complex systems but to do so means that new and challenging problems must be addressed.

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  • Different types of mutation can vary in size, from structural variants to single base-pair substitutions, but what they all have in common is that their nature, size and location are often determined either by specific characteristics of the local DNA sequence environment or by higher order features of the genomic architecture. The genomes of higher organisms are now known to contain "pervasive architectural flaws" in that certain DNA sequences are inherently mutation prone by virtue of their base composition, sequence repetitivity and/or epigenetic modification....

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  • In describing her art, Louise Nevelson has written: “I do not belong to any movement. As my work is related to the present time, it is bound to be related to that of others, consciously or not....” Her art may be more closely related to her collections of African art, American farm tools, architectural elements, and diverse other fragments of the past and her attraction to the art and architecture of pre-Columbian Mexico and Central America.

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  • As grounds for a systematic account of the arts, Herder’s approach seems problematic: as for Hegel, who later similarly attempts to use different means of sensible representation (or media) as a means systematically to differentiate the arts, both literature and architecture cause difficulties for Herder, as neither appears to be directed towards a single sense. (And this is only to mention two other very central, recognized arts in the (eighteenth century) “system of the arts.”) I shall not, however, be concerned with these overarching systematic concerns, however.

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  • c-Glutamyltranspeptidase (GGT; EC 2.3.2.2), an enzyme found in organ-isms from bacteria to mammals and plants, plays a central role in glutathi-one metabolism. Structural studies of GGTs from Escherichia coliand Helicobacter pylori have revealed detailed molecular mechanisms of catalysis and maturation.

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  • Growth factors are a group of proteins that regulate a wide variety of cel-lular processes, including proliferation, differentiation, motility, adhesion, and apoptosis of target cells. They play crucial roles in the formation and maintenance of tissue architecture in embryonic development and adult tissue homeostasis.

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  • Let’s see what the dinner party will involve? (See illustration of work breakdown structure) It is a lot more complicated than one would think. Major tasks include setting up and running the dinner, entertainment, and silent auction, finding a dinner speaker and clean up after the dinner is over. Beneath these major tasks are subtasks broken into 16 discrete categories. Each of the subtasks will break down into repeated or “one-off” steps. The complete list of steps with milestones runs to 75 entries. (See illustration of task list). ...

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  • Flowering plants now dominate the terrestrial ecosystems of the planet, and there are good reasons for supposing that the flower itself has been a major contributing factor to the spread of the Angiosperms. Although the Angiosperm flower is based on four whorls of organs – petals, sepal, stamens and carpels – the 300 000 odd species exhibit a huge array of different floral morphologies. Consider, e.g., the humble periwinkle flower and contrast it with the complex passion flower.

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  • Human Disc large (DLG1) has been demonstrated to be involved in the control of cell polarity and maintenance of tissue architecture, and is fre-quently lost in human tumours. However, the mechanisms controlling DLG1 expression are poorly understood.

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  • Type IV secretion systems (T4SS) are macromolecular assemblies used by bacteria to transport material across their membranes. T4SS are generally composed of a set of twelve proteins (VirB1–11 and VirD4). This repre-sents a dynamic machine powered by three ATPases.

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  • Iron overload in the liver may occur in clinical conditions such as hemo-chromatosis and nonalcoholic steatohepatitis, and may lead to the deterior-ation of the normal liver architecture by mechanisms not well understood. Although a relationship between the expression of ICAM-1, and classical major histocompatibility complex (MHC) class I molecules, and iron over-load has been reported, no relationship has been identified between iron overload and the expression of unconventional MHC class I molecules....

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  • The extracellular matrix (ECM) represents a complex organization of macromolecules that surrounds the cell and comprises the substratum onto which the cell may be attached. The properties and functions of the ECM depend ultimately on its structure, molecular components, architecture, and dynamic modulation. Because the critical role of ECM involved in cell biology and physiology has long been recognized, the structure and biology of the ECM have been extensively studied (Yurchenco and Birk 1994 ; Ayad et al. 1998 ; Robert 2001 ) .

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