Over the last three decades, knowledge on the molecular biology of human cancers has vastly expanded. A host of genes and proteins involved in cancer development and progression have been defined and many mechanisms at the molecular, cellular and even tissue level have been, at least partly, elucidated. Insights have also been gained into the molecular mechanisms underlying carcinogenesis by chemical, physical, and biological agents and into inherited susceptibility to cancer. Accordingly, Part I of the book presents many of the molecules and mechanisms generally important in human cancers.
Tham khảo sách 'carcinogenesis, diagnosis, and molecular targeted treatment for nasopharyngeal carcinoma edited by shih-shun chen', y tế - sức khoẻ, y học thường thức phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả
There is growing evidence on the importance of studies focusing on mechanisms and
strategies leading to cancer prevention. The plethora of approaches include regulation
of oxidative stress using antioxidant therapies, carefully balanced diets and living
habits, epidemiological evidence and molecular approaches on the role of key
biological molecules such as antioxidant enzymes, vitamins, proteins and naturally
occurring free radical scavengers as well as controversial results and clinical
applications. These are some of the topics that this book highlights.
There have been a significant number of advances
in the field of cancer research since the
first edition of Cancer Biology, which was published
in 1981. These include advances in defining
the genetic and phenotypic changes in cancer
cells, the genetic susceptibility to cancer, molecular
imaging to detect smaller and smaller tumors,
the regulation of gene expression, and the
‘‘-omics’’ techniquesofgenomics, proteomics,and
metabolomics, among others.
Gastric cancer is the second most common cause of cancer-related death in the world. There are no screening tests available for its diagnosis, therefore patients usually presents in late stages, associated with poor prognosis. Currently, many efforts are made toward new advances in the treatment strategies. The book makes an insight into the assessment of premalignant lesions, current management of early gastric cancer, risk and protective factors in gastric carcinogenesis.
The book brings together the expert knowledge
from more than 40 internationally renowned scientists, and conveys the basic
information, from classification, analysis and treatment, to novel molecular
mechanism and principles observed in acute leukemia. It combines and assembles
scientific groups worldwide dealing with acute leukemia, from the molecular to the
clinical point of view. After a thorough revision of more than 30 reviews submitted,
only about 50 percent were selected for the first phase of this editorial process....
MicroRNAs (miRNAs) are small, noncoding RNAs of 18–25 nucleotides
that are generally believed to either block the translation or induce the deg-radation of target mRNA. miRNAs have been shown to play fundamental
roles in diverse biological and pathological processes, including cell prolif-eration, differentiation, apoptosis and carcinogenesis.
One of the more interesting aspects of the announcement by Ian Wilmut that
he and his colleagues in Scotland had successfully “cloned” a sheep born in 1996
was the enormous public interest and misunderstanding about cloning. The common
misperception, which persists to this day, is that a cloned individual would
be an exact duplicate of another.
Abstract Mitochondria are sub-cellular organelles that produce adenosine triphosphate (ATP) through oxidative phosphorylation (OXPHOS). As suggested over 70 years ago by Otto Warburg and recently confirmed with molecular techniques, alterations in respiratory activity and in mitochondrial DNA (mtDNA) appear to be common features of malignant cells. Somatic mtDNA mutations have been reported in many types of cancer cells, and some reports document the prevalence of inherited mitochondrial DNA polymorphisms in cancer patients.
It is important that cord blood transplantation is one of the risk
factors of symptomatic adenoviremia (Robin et al., 2007), which develops to acute renal
failure in the terminal stage (Abe T et al., 2009).
At present, there is no established consensus about the treatment for acute renal failure
induced by adenovirus after stem cell transplantation. This chapter focuses on the recent
advances in diagnosis, mostly due to the development of molecular methods, and
Carcinogenesis covers molecular, biochemical and cellular processes that underpin this field. The complex nature of cancer means that a broad understanding of these processes is advantageous when designing novel preventative, therapeutic or diagnostic strategies. This book commences with chapters discussing cancer predisposition and pre-cancerous lesions. Factors that initiate or progress cancer development, including viral, hormonal, oncogenic and biochemical stimuli are then described, as are interactions with the cancer extracellular environment....
Pancreatic cancer is one of the most fatal human malignancies with extremely poor
prognosis making it the fourth leading cause of cancer-related deaths in the United
States. The molecular mechanisms of pancreatic carcinogenesis are not well
understood. The major focus of these two books is towards the understanding of the
basic biology of pancreatic carcinogenesis, identification of newer molecular targets
and the development of adjuvant and neoadjuvant therapies.
In the past 15 years, molecular biologists and geneticists have uncovered
some of the most basic mechanisms by means of which normal stem cells
in a certain organ or tissue develop into cancerous tumors. This biological
knowledge serves as a basis for various models of carcinogenesis.
Admission to veterinary programmes around the globe is a highly competitive process, with
candidates typically required to attain top grades in science-based subjects to qualify for
entry. Owing to the large number of applicants to veterinary schools, interviews often form
part of the selection process. Although curricula will vary from provider to provider,
veterinary programmes are extremely intensive courses of study and typically include pre-
clinical, para-clinical and clinical components.
The Hsp90 molecular chaperone catalyses the final activa-tion step of many of themost important regulatory proteins
of eukaryotic cells. The antibiotics geldanamycin and rad-icicol act as highly selective inhibitors of in vivo Hsp90
function through their ability to bindwithin the ADP/ATP
binding pocket of the chaperone. Drugs based on these
compounds are now being developed as anticancer agents,
their administration having the potential to inactivate sim-ultaneously several of the targets critical for counteracting
multistep carcinogenesis. ...
Christina DeStefano-Shields graduated
with a B.S. in Biochemistry and Molecular
Biology from the University of Georgia and
then worked as a research assistant at the
University of California Berkeley and Davis
campuses. She was interested in research
that would combine molecular mechanisms
of toxicants, understanding toxicants in
the environment, and translation of this
research to improve human and environmental