Molecular concepts

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  • “This book is both up-to-date and “This book covers aiswide range of very informative for traditional subjects, and it refreshing to and new generations of plant virologists in both industrialized and developing nations of the world. Moreover, some chapters present very interesting concepts regarding the use of molecular techniques to gain new insight into long-standing pathological issues, such as virus evolution, host adaptation, and epidemiology.

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  • From this Chapter we will study thermal properties of matter, that is what means the terms “hot” or “cold”, what is the difference between “heat” and “temparature”, and the laws relative to these concepts. We will know that the thermal phenomena are determined by internal motions of molecules inside a matter. There exists a form of energy which is called thermal energy, or “heat”, which is the total energy of all molecular motions, or internal energy.

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  • Mainly, the genome project has fundamentally changed the way in which we approach questions in biology. The technology that the genome project has enabled, rather than the data it has produced, has induced the most profound impact on our conduct of biological research. In particular, functional genomics approaches, suchs as DNA microarrays, proteomics and metabolomics have greatly increased the rate at which we can generate data on biological systems allowing us, to begin to observe on a molecular level the holistic response of an organism to a particular stimulus (Quackenbush, 2006)....

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  • Chapter 2 - The molecular nature of genes. Before we begin to study in detail the structure and activities of genes, and the experimental evidence underlying those concepts, we need a fuller outline of the adventure that lies before us. Thus, in this chapter and in chapter 3, we will fl esh out the brief history of molecular biology presented in chapter 1. In this chapter we will begin this task by considering the behavior of genes as molecules.

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  • Before we begin to study in detail the structure and activities of genes, and the experimental evidence underlying those concepts, we need a fuller outline of the adventure that lies before us. Thus, in this chapter and in chapter 3, we will fl esh out the brief history of molecular biology presented in chapter 1. In this chapter we will begin this task by considering the behavior of genes as molecules.

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  • Thus, in living cells, the rates of anterograde and retrograde transport between the two organelles appear to have a substantial effect on the morphology of the Golgi. The effect of the balance between anterograde and retrograde transport on the morphology of the ER remains to be explored. Recently, increasing evidence has suggested that alteration in Golgi morphology during mitosis is not a passive process but rather an active one, which is highly coordinated with entry into mitosis and its progression.

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  • During the last three decades, important advances have been made in the available treatments for the loss of skeletal tissue as a result of trauma or disease. The application of large skeletal allografts and total joint replacement have become successful and reproducible treatment options. Unfortunately there still is a significant incidence of failure because of mechanical or biological complications.

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  • As a research scientist in the area of human nutrition, I have observed a sea change in emphasis within my field over the past 10–15 years. There have always been dynamics within the subject: During the first half of the twentieth century, scientists grappled with discovering the essential micronutrients and with characterizing the biological effects of their deficiency. This interest in “too little” was supplanted in the mid-1980s by a preoccu- pation with too much—too much fat, too much sugar, and too much obesity.

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  • Since this book was first published in 1993, the Advanced Paediatric Life Support (APLS) concept and courses have gone a great way towards their aim of bringing simple guidelines for the management of ill and injured children to front-line doctors and nurses. Over the years an increasing number of experts have contributed to the work and we extend our thanks both to them and also to our instructors who unceasingly provide helpful feedback.The Advanced Paediatric Life Support Course is now well established in several countries outside the United Kingdom.

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  • Pediatric cardiology section enlightens us on cardiovascular changes in fetuses / infants as well as some pediatric cardiovascular surgical procedures needing skill under recent developments. Pediatric hemato-oncology section explains novel developments of well-known diseases such as neuroblastoma and thalassemias. For instance; whole genome searches and molecular basis for diagnosis of neuroblastoma are discussed. However, this section also includes some common complications of oncology e.g. fertility and fatigue seen in these patients.

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  • Few of us can any longer keep up with the flood of scientific literature, even in specialized subfields. Any attempt to do more and be broadly educated with respect to a large domain of science has the appearance of tilting at windmills. Yet the synthesis of ideas drawn from different subjects into new, powerful, general concepts is as valuable as ever, and the desire to remain educated persists in all scientists.

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  • This book is divided into different research areas relevant in Bioinformatics such as biological networks, next generation sequencing, high performance computing, molecular modeling, structural bioinformatics, molecular modeling and intelligent data analysis. Each book section introduces the basic concepts and then explains its application to problems of great relevance, so both novice and expert readers can benefit from the information and research works presented here.

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  • The past three decades have witnessed a steadily increasing awareness of the need to empower women through measures to increase social, economic and political equity, and broader access to fundamental human rights, improvements in nutrition, basic health and education. Along with awareness of the subordinate status of women has come the concept of gender as an overarching socio-cultural variable, seen in relation to other factors, such as race, class, age and ethnicity.

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  • Every patient knows to seek medical help when his or her aches and pains become too much to bear, but how does the healthcare provider determine what is wrong and what to do to restore the patient to good health? The answer depends on the patient’s signs and symptoms and the results from medical tests. In this book you will learn to identify these signs and symptoms, interpret the medical test results, and perform the nursing interventions that will assist in solving or alleviating the patient’s medical problem.

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  • MECHANICS IS THE ENGINEERING SCIENCE that deals with studying, defining, and mathematically quantifying “interactions” that take place among “things” in our universe. Our ability to perceive the physical manifestation of such interactions is embedded in the concept of a force, and the “things” that transmit forces among themselves are classified for purposes of analysis as being solid, fluid, or some combination of the two.

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  • Storage of putative stem/progenitor cells is also an attractive research target in tissue engineering. Collection of cells for tissue engineering is less invasive than conventional tissue or organ transplantation. However, repetitive collection of cells can stress patients. If the stem/progenitor cells could be stored, it is possible that they could be repeatedly used for future therapy, reducing the burden and the cost to patients. The concept of banking stem/progenitor cells in storage is not new. Stem/progenitor cell populations decrease in size with age (D'Ippolito et al.

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  • Forecasting credit portfolio risk poses a challenge for the banking industry. One important goal of modern credit portfolio models is the forecast of the future credit risk given the information which is available at the point of time the forecast is made. Thus, the discussion paper “Forecasting Credit Portfolio Risk“ proposes a dynamic concept for the forecast of the risk parameters default probabilities and default correlations.

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  • We present measures of board structure for the restating and control samples in panel B of Table 5. The two groups of firms have similar board structures. The median board size for restating (control) firms is 7 (8) members. The median proportion of independent directors (PID) is about 71 percent in each sample. About 5 percent of the independent directors hold 5 percent or larger blocks of equity (PID5) in both groups. One striking difference between the two groups is in the incidence of an independent director with financial expertise (IDFE).

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  • The potential value of artificial neural networks (ANNs) as a predictor of malignancy has now been widely recognised. The concept of ANNs dates back to the early part of the 20th century; however, their latest resurrection started in earnest in the 1980s when they were applied to many problems in the areas of pattern recognition, control, and optimisation.

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