Tham khảo sách 'carcinogenesis, diagnosis, and molecular targeted treatment for nasopharyngeal carcinoma edited by shih-shun chen', y tế - sức khoẻ, y học thường thức phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả
Plants defend themselves from other organisms by elaborating bioactive chemical
defences. This is the essential basis of the use of herbal medicines that still represents a
major therapeutic resort for much of humanity However, at the outset, it must be stated that
any plant that is not part of our evolved dietary cultures is potentially dangerous.
Commercial herbal medicinal preparations approved by expert regulatory authorities have a
significant place in mainstream conventional medicine and in complementary medicine.
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: In vivo Molecular targeting effects of anti-Sp17ICG-Der-02 on hepatocellular carcinoma evaluated by an optical imaging system
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration...
"Molecular imaging" has been previously defined as "the in vivo characterization and measurement of biologic processes at the cellular and molecular level." This broad definition emerged during the last few years as a consequence of the convergence of molecular and cell biology with imaging science, including medical physics and technology. One of the major goals of molecular imaging has become the development of noninvasive strategies of "molecular profiling" in living subjects, i.e.
Sulfoquinovosylacylglycerols (SQAGs), in particular compounds with C18
fatty acid(s) on the glycerol moiety, may be clinically promising antitumor
and⁄or immunosuppressive agents. They were found originally as inhibitors
of mammalian DNA polymerases. However, SQAGs can arrest cultured
mammalian cells not only at S phase but also at M phase, suggesting they
have several molecular targets.
Numerous virus–target cell interactions have been described, and it is now clear that different viruses can use similar host-cell receptors for entry. The list of certain and likely host receptors for viral pathogens is long. Among the host membrane components that can serve as receptors for viruses are sialic acids, gangliosides, glycosaminoglycans, integrins and other members of the immunoglobulin superfamily, histocompatibility antigens, and regulators and receptors for complement components.
RNA-mediated gene silencing (RNA interference) is a powerful way to
knock down gene expression and has revolutionized the fields of cellular
and molecular biology. Indeed, the transfection of cultured cells with small
interfering RNAs (siRNAs) is currently considered to be the best and easi-est approach to loss-of-function experiments.
Various bacterial protein toxins and effectors target the actin cytoskeleton.
At least three groups of toxins⁄effectors can be identified, which directly
modify actin molecules. One group of toxins⁄effectors causes ADP-ribosy-lation of actin at arginine-177, thereby inhibiting actin polymerization.
The mitogenic toxin fromPasteurella multocida(PMT) is a member of the
dermonecrotic toxin family, which includes toxins fromBordetella, Escheri-chia coliandYersinia. Members of the dermonecrotic toxin family modu-late G-protein targets in host cells through selective deamidation and⁄or
transglutamination of a critical active site Gln residue in the G-protein tar-get, which results in the activation of intrinsic GTPase activity.
Most drugs against malaria that are available or under development target
a single process of the parasite infective cycle, favouring the appearance of
resistant mutants which are easily spread in areas under chemotherapeutic
Bacterial type IV secretion systems (T4SS) form supramolecular protein
complexes that are capable of transporting DNA or protein substrates
across the bacterial cell envelope and, in many cases, also across eukaryotic
target cell membranes.
Reliable prediction of specific transcription factor target genes is a major
challenge in systems biology and functional genomics. Current
sequence-based methods yield many false predictions, due to the short and
degenerated DNA-binding motifs.
NEDD8 is a ubiquitin-like protein that controls vital bio-logical events through its conjugation to target proteins.
Previously, we identifieda negative regulator oftheNEDD8
conjugation system, NEDD8 ultimate buster-1 (NUB1),
that recruits NEDD8 and its conjugates to the proteasome
for degradation. Recently, we performed yeast two-hybrid
screening with NUB1 as bait and isolated a ubiquitin pre-cursor UbC1 that is composed ofnine tandem repeats of
a ubiquitin unit through a-peptide bonds.
Targeting signals are critical for proteins to find their specific cellular desti-nation. Signals for protein targeting to the endoplasmic reticulum (ER),
mitochondria, peroxisome and nucleus are distinct and the mechanisms of
protein translocation across these membrane compartments also vary
Pancreatic cancer is one of the most fatal human malignancies with extremely poor
prognosis making it the fourth leading cause of cancer-related deaths in the United
States. The molecular mechanisms of pancreatic carcinogenesis are not well
understood. The major focus of these two books is towards the understanding of the
basic biology of pancreatic carcinogenesis, identification of newer molecular targets
and the development of adjuvant and neoadjuvant therapies.