Multiple integrals

The extent to which changes in gene expression can influence cardiovascular disease risk across different tissue types has not yet been systematically explored. We have developed an analysis pipeline that integrates tissue-specific gene expression, Mendelian randomization and multiple-trait colocalization to develop functional mechanistic insight into the causal pathway from a genetic variant to a complex trait.

15p vibransone 28-03-2024 2 2   Download

The mitochondrial genome is transcribed as continuous polycistrons of RNA containing multiple genes. As a consequence, post-transcriptional events are critical for the regulation of gene expression and therefore all aspects of mitochondrial function.

12p vioraclene 31-03-2024 2 2   Download

Smith-Magenis syndrome (SMS) is a developmental disability/multiple congenital anomaly disorder resulting from haploinsufficiency of RAI1. It is characterized by distinctive facial features, brachydactyly, sleep disturbances, and stereotypic behaviors.

15p vioraclene 31-03-2024 2 2   Download

The decision-making process for supply chain management is complex and involves multiple people across multiple teams. This article deals with the problem of choosing an optimal management solution in a turbulent economy. We systematise new management risks in the context of a pandemic are systematized. A method for constructing an integral risk assessment function for managerial decisionmaking is proposed. We identify aneed for an expert community to make more informed decisions has been identified.

5p longtimenosee06 27-03-2024 3 2   Download

We report the findings from 4437 individuals (3219 patients and 1218 relatives) who have been analyzed by whole genome sequencing (WGS) at the Genomic Medicine Center Karolinska-Rare Diseases (GMCKRD) since mid-2015.

15p vibransone 28-03-2024 2 2   Download

DNA sequencing has unveiled extensive tumor heterogeneity in several different cancer types, with many exhibiting diverse subclonal populations. Identifying and tracing mutations throughout the expansion and progression of a tumor represents a significant challenge.

11p vibransone 28-03-2024 1 1   Download

Preclinical studies and early clinical trials have shown that targeting cancer neoantigens is a promising approach towards the development of personalized cancer immunotherapies. DNA vaccines can be rapidly and efficiently manufactured and can integrate multiple neoantigens simultaneously.

13p vibransone 28-03-2024 1 1   Download

Single liquid biopsy analytes (LBAs) have been utilized for therapy selection in metastatic breast cancer (MBC). We performed integrative statistical analyses to examine the clinical relevance of using multiple LBAs: matched circulating tumor cell (CTC) mRNA, CTC genomic DNA (gDNA), extracellular vesicle (EV) mRNA, and cellfree DNA (cfDNA).

14p vibransone 28-03-2024 3 2   Download

The plasticity of monocytes enables them to exert multiple roles during an immune response, including promoting immune tolerance. How monocytes alter their functions to convey immune tolerance in the context of lower respiratory tract infections in humans is not well understood.

17p vibransone 28-03-2024 1 1   Download

To study methodological approaches to employee remuneration planning taking into account the relationship between the types of supply chain management (SCM) and the staff effectiveness based on the multiple regression model and evaluation of the optimal payment times based on a dynamic model with a distributed lag. The application of the concept of sustainable supply chain management in the operation strategy of industrial enterprise seems to be a very important function. This supply chain also covers all three aspects of sustainable development: business, environmental, and social.

9p longtimenosee06 27-03-2024 1 1   Download

The multiple de novo copy number variant (MdnCNV) phenotype is described by having four or more constitutional de novo CNVs (dnCNVs) arising independently throughout the human genome within one generation. It is a rare peri-zygotic mutational event, previously reported to be seen once in every 12,000 individuals referred for genome-wide chromosomal microarray analysis due to congenital abnormalities.

21p viellison 28-03-2024 2 2   Download

Ebook "Reactivity of metal-metal bonds" are reviewed under the supervision of the Editors with the assistance of the Series Advisory Board and are selected to maintain the integrity of the symposia; however, verbatim reproductions of previously published papers are not accepted. Both reviews and reports of research are acceptable since symposia may embrace both types of presentation.

324p coduathanh1122 27-03-2024 1 1   Download

Spatial multi-omic studies have emerged as a promising approach to comprehensively analyze cells in tissues, enabling the joint analysis of multiple data modalities like transcriptome, epigenome, proteome, and metabolome in parallel or even the same tissue section. This review focuses on the recent advancements in spatial multi-omics technologies, including novel data modalities and computational approaches.

17p vicwell 29-02-2024 4 2   Download

Part 2 book "Calculus" includes content: Mathematical modeling with differential equations, infinite series, parametric and polar curves - conic sections, three dimensional space - vectors, vector valued functions, partial derivatives, multiple integrals, topics in vector calculus.

732p muasambanhan07 18-02-2024 1 1   Download

Part 2 book "A textbook of engineering mathematics I" includes content: Multiple integrals; double integrals; working rule; double integration for polar curves; change of the order of integration; change of variables in a multiple integral; beta and gamma functions; transformations of gamma function; transformations of beta function; relation between beta and gamma functions; some important deductions; duplication formula; evaluate the integrals; application to area (double integrals),... and other contents.

177p muasambanhan07 18-02-2024 2 1   Download

Part 2 book "Advanced engineering mathematics" includes content: Multiple integration, integral functions, vector analysis, complax analysis, optimization and linear programming.

467p muasambanhan06 01-02-2024 7 2   Download

Part 2 book "Engineering mathematics" includes content: Techniques of integration; applications of integration; further topics in integration, numerical integration; Taylor polynomials, Taylor series and Maclaurin series, ordinary differential equations; ordinary differential equations; the Laplace transform; difference equations and the Z transform; fourier series; the Fourier transform; functions of several variables; vector calculus; line integrals and multiple integrals; probability; statistics and probability distributions.

548p muasambanhan06 01-02-2024 1 0   Download

Ebook "Landscape ecology in Asian cultures" to understand and manage such complex landscapes, interdisciplinary and transdisciplinary approaches are necessary, emphasizing the integration of natural and social sciences and considering multiple landscape functions. The spatial patterns of Asian landscapes are strongly related to human activities and their impacts.

336p tachieuhoa 28-01-2024 2 2   Download

Cantharidin (CTD) is the active ingredient of Chinese medicine, which has been traditionally used in multiple cancers treatment, especially in hepatocellular carcinoma (HCC). However, a comprehensive analysis of the CTD-related molecular mechanism is still necessary to understand its functions in HCC treatment. This study aimed to reveal the novel molecular targets and regulatory networks of CTD in HCC.

14p vileonardodavinci 23-12-2023 5 2   Download

Continued part 1, part 2 of ebook "Strengthening information and control systems: The Synergy between information technology and accounting models" provides readers with contents including: from theory to practice - first adoption of integrated reporting by the Italian public utilities; business intelligence in public sector organizations - a case study; management control systems for the water concessionaires governance - a multiple cases study in the Italian seaports; benefits and barriers of social/collaborative ERP systems - a state of the art and research agenda;...

149p mocthanhdao0210 19-11-2023 4 3   Download