Xem 1-20 trên 129 kết quả Mutations associated
  • An intact two-parent family and regular church attendance are each associated with fewer problem behaviors, more positive social development, and fewer parental concerns about the child’s learning and achievement. Taken together, the two home-environment factors have an additive relationship with child well-being. That is, children who live in an intact family and attend religious services regularly generally come out best on child development measures, while children who do neither come out worst.

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  • Oxidative stress and imbalance between free radical generation and detoxi-fication may play a pivotal role in the pathogenesis of Leber’s hereditary optic neuropathy (LHON). Mitochondria, carrying the homoplasmic 11778⁄ND4, 3460⁄ND1 and 14484⁄ND6 mtDNA point mutations associ-ated with LHON, were used to generate osteosarcoma-derived cybrids. Enhanced mitochondrial production of reactive oxygen species has recently been demonstrated in these cybrids [Beretta S, Mattavelli L, Sala G, Trem-olizzo L, Schapira AHV, Martinuzzi A, Carelli V & Ferrarese C (2004) Brain127, 2183–2192]. ...

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Prevalence of reverse transcriptase and protease mutations associated with antiretroviral drug resistance among drug-naïve HIV-1 infected pregnant women in Kagera and Kilimanjaro regions, Tanzania...

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  • Vitamin E is an important topic because many benefits and some risks have been attributed to it when used as a nutritional supplement. Moreover, there has been considerable progress in the basic science of this vitamin in recent years. This volume reviews recent aspects of the biochemistry and molecular biology of this vitamin, associated macromolecules, metabolism of the vitamin and its derivatives, and its many roles in health and disease. The various contributions comprising this volume are listed here in the order in which they are presented in the volume....

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  • The paper seeks to assess how a major policy regime change – such as the introduction of the currency board in Bulgaria – affects the flow of bank credit to the corporate sector. An attempt is made to identify the determinants of corporate credit separately from the viewpoint of lenders and borrowers. The estimated credit supply and credit demand equations provide empirical evidence of important changes in microeconomic behavioral patterns which can be associated with the policy regime change.

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  • Multiple Sleep Latency Test (MSLT) can objectively evaluate daytime sleepiness. When used as diagnostic prosedure of central hypersomnia it should be done during the day after polysomnographically documented adequate night sleep, which lasts at least six hours and after two weeks of regular sleep. (Carscadon & Dement, 1982, American sleep disorders association, 1992) (ICSD-2, 2005). Evaluation of MSLT starts 1,5-3 hours after morning awakening and consists of 5, or at least 4 records of polysomnography, each lasting 20minutes (Littner et al., 2005).

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  • The most basic yet comprehensive component of a strong institutional image is a unified visual presentation. Collectively, all elements of the University of Kentucky must present to the world a consistent image that reflects our quality, professionalism and mission. The University of Kentucky name carries heavy responsibility. It stands as the sum of the institution’s many parts and embodies the authentic, recognizable essence of this institution. It must reinforce to many diverse audiences a definitive and unique impression.

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  • Directive 2002/45/EC applies more specifically to leather production, and prohibits the marketing of substances and preparations for the fat liquoring of leather containing C10-C13 chloro-alkanes in concentrations above 1%. For all pieces of furniture, reference should be made to Directive 1999/44/EC on certain aspects of the sale of consumer goods and associated guarantees. This Directive regulates fitness for purpose of consumer goods and the liability of the seller. Directive 1999/44/EC provides basic protection to consumers against inferior products.

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  • Three point mutations R335S, L336V and V476L, distin-guish the sequence of a cytochrome P450CYP6A2 variant assumed to be responsible for 1,1,1-trichloro-2,2-bis-(4¢-chlorophenyl)ethane (DDT) resistance in theRDDT R strain ofDrosophila melanogaster. To determine the impact of each mutation on the function of CYP6A2, the wild-type enzyme (CYP6A2wt) ofCyp6a2was expressed inEscheri-chia colias well as three variants carrying a single mutation, the double mutant CYP6A2vSV and the triple mutant CYP6A2vSVL. All CYP6A2 variants were less stable than the CYP6A2wt protein. ...

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  • Mutations in the tumor suppressor breast cancer susceptibility gene 1 (BRCA1), an important player in the DNA damage response, apoptosis, cell cycle regulation and transcription, confer a significantly elevated life-time risk for breast and ovarian cancer.

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  • Sedation is the important factor in comfort of brain trauma patients. Insuffient sedation causes hypertension, tachycardia, hypoxia, hypercapnia and uncomfortable with ventilator. On the other hand excess sedation causes hypotansion, bradycardia, coma, respiratory depresion, ileus, renal insufficiency, veinous stasis and immunosupression. For the patients in the critical care unit firstly nonpharmacological method should be experinced for sedation. The patients should be frequently oriented.

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  • However, despite sharing a common signature CLLs expressing mutated and unmutated IgVH genes differentially express more than 100 genes. Among these, over-expression of genes encoding zeta-chain-associated protein 70 (ZAP-70), lipoprotein lipase (LPL), BCL-7a, dystrophin and gravin are observed in the aggressive unmutated cases, while stable mutated cases over-express Wnt3, CTLA-4, NRIP1 nuclear receptor gene, ADAM29 and the transcription factor TCF7 [53]. These results suggest that indolent mutated and aggressive unmutated CLLs constitute two variants of the same disease.

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  • This paper reviews the use of diagnostics in buildings, both in commissioning and in operations and maintenance. The difference between fault detection and fault diagnosis is defined. The kinds of fault that can arise at different stages of the building life cycle are described and the ways that these different kinds of fault can be detected are discussed. Other issues addressed include manual and automatic methods and whole building vs. component-level approaches.

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  • Regulators to date have opted for a relatively "non-interventionist" approach to environmental accounting reform. The U.S. Environmental Protection Agency, for instance, through surveys and case studies, has identified weaknesses in private sector environmental accounting and promotes the diffusion of accounting "best practices." This outreach- and communication-based approach may be expanded upon in the future, however. There currently are calls from some environmental advocates for more aggressive regulatory actions in this area, such as mandated environmental accounting.

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  • The putative CLL precursor could be an antigen-experienced CD27+ B cell, expanded either in the course of a GC B-cell T-dependent or T-independent response by chronic antigen- stimulation through extrinsic or autoantigens. Over time, genetic abnormalities may accumulate in the genome of these chronically stimulated B cells and lead to the outgrow of clones with MBL phenotype. Additional genetic aberrations may be incorporated in the course of proliferation leading to the oncogenic hit that transform these precursor in bona fide CLL cells. ...

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  • No one knows more about a broad range of prescription drugs and other medications than your pharmacist. Pharmacists study all the aspects of prescription drug therapy, with an emphasis on safe patient care. The Doctor of Pharmacy (PharmD) degree requires at least two years of col- lege followed by four years of professional pharmacy study. To keep their licenses, pharmacists must take several new courses every year to every two years, depending on the state they are licensed in. Some pharma- cists take extra training to specialize in such areas as geriatric pharmacy. ...

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  • Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Codon usage in vertebrates is associated with a low risk of acquiring nonsense mutations

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  • The GCC region is a small but important part of the global economy. Its 2007 real GDP was around US$810 billion, accounting for just 2.1% of the global total 12 . Despite the relatively small size of their economies and populations13 , the rate of GDP growth in GCC countries reached 6.4% in 2007, which is similar to the Asia Pacific average (5% to 6%). Its growth rate exceeded the averages for Latin America, Europe, the OECD and the Middle East. In terms of GDP per capita, Qatar, the UAE, and Kuwait rank among the highest...

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  • The letter of intention to audit is issued in the post to the organisation selected for inspection. In addition, an electronic notification may also be sent via email provided that a valid e-mail address for the compliance officer/regulatory function is to hand. The letter of intention to audit will specify a date for the inspection to take place and request that the data controller contact the Office of the Data Protection Commissioner to confirm whether the date is agreeable.

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  • As explained in Sales that are generally nontaxable, charges for composed type only or reproduction proofs of composed type only, are not taxable. Charges for the composition of type are considered charges for a service, unless the charges are part of the sale of printed matter. “Composed type” includes type together with lined borders and plain, straight, fancy, or curved lines. Composed type also includes charts, tables, graphs, and similar methods of providing information.

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