Neck cancer

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  • Harrison's Internal Medicine Chapter 84. Head and Neck Cancer Head and Neck Cancer: Introduction Epithelial carcinomas of the head and neck arise from the mucosal surfaces in the head and neck area and typically are squamous cell in origin. This category includes tumors of the paranasal sinuses, the oral cavity, and the nasopharynx, oropharynx, hypopharynx, and larynx. Tumors of the salivary glands differ from the more common carcinomas of the head and neck in etiology, histopathology, clinical presentation, and therapy. Thyroid malignancies are described in Chap. 335.

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  • Head and Neck Cancer: Treatment Patients with head and neck cancer can be categorized into three clinical groups: those with localized disease, those with locally or regionally advanced disease, and those with recurrent and/or metastatic disease. Comorbidities associated with tobacco and alcohol abuse can affect treatment outcome and define long-term risks for patients who are cured of their disease. Localized Disease Nearly one-third of patients have localized disease; that is, T1 or T2 (stage I or stage II) lesions without detectable lymph node involvement or distant metastases.

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  • Chemoprevention β-Carotene and cis-retinoic acid can lead to the regression of leukoplakia. However, cis-retinoic acid does not reduce the incidence of second primaries Treatment Complications Complications from treatment of head and neck cancer are usually correlated to the extent of surgery and exposure of normal tissue structures to radiation. Currently, the extent of surgery has been limited or completely replaced by chemotherapy and radiation therapy as the primary approach. Acute complications of radiation include mucositis and dysphagia.

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  • Clinical Presentation and Differential Diagnosis Most head and neck cancers occur after age 50, although these cancers can appear in younger patients, including those without known risk factors. The manifestations vary according to the stage and primary site of the tumor. Patients with nonspecific signs and symptoms in the head and neck area should be evaluated with a thorough otolaryngologic exam, particularly if symptoms persist longer than 2–4 weeks. Cancer of the nasopharynx typically does not cause early symptoms.

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  • Table 84-1 TNM Classification for Head and Neck Cancer (Except Nasopharyngeal) Primary Tumor Site T Grade Oropharynx Hypopharynx T1 0–2 cm 0–2 cm T2 2.

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  • Squamous cell carcinoma of the head and neck affects more than 40,000 people each year in the U.S., and at least 13,000 people each year die of this disease. In many countries, oral cancers are one of the leading causes of cancer incidence, and a major cause of morbidity and mortality. Sadly, these statistics have not improved despite clear delineation of tobacco and alcohol as contributory or etiologic in at least 80% of cases.

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  • Tham khảo sách 'head and neck cancer edited by mark agulnik', y tế - sức khoẻ, y học thường thức phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả

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  • The head and neck is a region of considerable anatomical and functional complexity, making the accurate staging of a head and neck neoplasm a challenging task. The clinician often detects pathology, but may not appreciate, based on the physical examination, the entire submucosal tumor extension, nor the possible regional and distant disease spread. The introduction of CT and MRI has revolutionized head and neck radiology. Current radiological modalities provide a reliable visualization of the head and neck structures to an unprecedented level of detail.

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Dysphagia in head and neck cancer patients following intensity modulated radiotherapy (IMRT)...

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  • Table 84-2 Definition of TNM–Nasopharynx Primary Tumor (T) Stage Grouping TX Cannot assessed be 0 Stage Tis N0 M0 T0 No evidence I Stage T1 N0 M0 Tis Carcinoma in situ IIA Stage T2a N0 M0 T1 Tumor confined IIB Stage T1 N1 M0 to the nasopharynx T2 Tumor extends to soft tissues T2 N1 M0 T2a extends to Tumor the T2a N1 M0 oropharynx and/or nasal cavity parapharyngeal extension w/o T2b Any tumor with extension parapharyngeal T2b N1 M0 T3 Tumor involves T2b N1 M0 bony structures and/or paranasal sinuses T4 Tumor intracranial with e...

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Long-term outcome and patterns of failure in patients with advanced head and neck cancer...

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  • Making a Treatment Plan From information on the extent of disease and the prognosis and in conjunction with the patient's wishes, it is determined whether the treatment approach should be curative or palliative in intent. Cooperation among the various professionals involved in cancer treatment is of the utmost importance in treatment planning.

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: CT-guided iodine-125 seed permanent implantation for recurrent head and neck cancers...

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: F-FDG PET/CT-based gross tumor volume definition for radiotherapy in head and neck Cancer: a correlation study between suitable uptake value threshold and tumor parameters...

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Early clinical experience with volumetric modulated arc therapy in head and neck cancer patients...

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Assessment of peri- and postoperative complications and Karnofsky-performance status in head and neck cancer patients after radiation or chemoradiation that underwent surgery with regional or free-flap reconstruction for salvage, palliation, or to improve function...

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: " The epidermal growth factor receptor (EGFR) in head and neck cancer: its role and treatment implications...

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Systems biology-defined NF-κB regulons, interacting signal pathways and networks are implicated in the malignant phenotype of head and neck cancer cell lines differing in p53 status...

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  • Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Research Article Automatic Speech Recognition Systems for the Evaluation of Voice and Speech Disorders in Head and Neck Cancer

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  • Tham khảo sách 'diagnosis and management of head and neck cancer', y tế - sức khoẻ, y dược phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả

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