Angiogenesis is an extension process of the cardiovascular network within human body. It is usually triggered by the demand of oxygen and nutrients from the fast growing tissue and uncontrollably dividing cells, as seen during wound healing and tumor progression. This book focuses on tumor angiogenesis and includes 8 chapters written by highly experienced scholars from five different countries.
Ampliﬁcation of N-myc oncogene is a frequent event in advanced stages of human neuroblastoma and correlates with poor prognosis and enhanced neovascularization. Angiogenesis is an indispensable prerequisite for the progression and metastasis of solid malignancies, which is modulated by tumor suppressors and oncogenes. We have addressed the possibility that N-myc oncogene might regulate angiogenesis in neuroblastoma. Here, we report that experimental N-Myc overexpression results in down-regulation of leukemia inhibitory factor (LIF), a modulator of endothelial cell proliferation....
Peptides which should be generated from the neuropeptide
FF (NPFF) precursor were identified in a neuronal (human
neuroblastoma SH-SY5Y) cell line and in COS-7 cells after
transient transfection of the human proNPFFAcDNA and
were comparedwith those detected in themouse spinal cord.
After reverse-phase high performance liquid chromatogra-phy of soluble material, NPFF-related peptides were im-munodetected with antisera raised against NPFF and
identified by using on-line capillary liquid chromatography/
nanospray ion trap tandem mass spectrometry. ...
Xếp lạo theo giải phẫu bệnh A.Các u của nơron thần kinh
-U nguyên bào thần kinh khứu giác, xúc giác B. Các u tế bào thần kinh đệm( gliomas)
U tế bào hình sao( astrocytoma)
-U tế bào hình sao ít nhành( oligodendroglioma) -U màng não thất( ependymoma)
-U đám rối mạch mạc (choroid plexus tumors) -U tế bào thần kinh đệm hỗn hợp