Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Long-term tracking of neurological complications of encephalopathy and myopathy in a patient with nephropathic cystinosis: a case report and review of the literature
Neuro-oncology has evolved substantially as a
clinical and research discipline over the past few
decades. Initially the province of isolated devotees,
it has become a well-recognized subspecialty
of neurology, oncology, and neurosurgery. The
Society for Neuro-Oncology, founded just five
years ago, now has almost 1000 members. Most
tertiary care hospitals have staff physicians who
consider themselves neuro-oncologists. These physicians
typically are involved in the evaluation and
management of neurologic complications of systemic
cancer and its treatment, as well as of primary
Harrison's Internal Medicine Chapter 97. Paraneoplastic Neurologic Syndromes
Paraneoplastic Neurologic Syndromes: Introduction
Paraneoplastic neurologic disorders (PNDs) are cancer-related syndromes that can affect any part of the nervous system (Table 97-1). They are remote effects of cancer, caused by mechanisms other than metastasis or by any of the complications of cancer such as coagulopathy, stroke, metabolic and nutritional conditions, infections, and side effects of cancer therapy. In 60% of patients the neurologic symptoms precede the cancer diagnosis.
Second, it should not be forgot that several neuroprotectant have failed not because
they lacked efficacy, but because they revealed unexpected side effects. Many NMDAreceptor
antagonists were discarded because in clinical trials they showed psychedelic
unwanted effects. Tirilazad, an antioxidant belonging to the “lazaroid” class of
antioxidants, unexpectedly worsened outcome of ischemic stroke, a fact very likely
explained by some unexpected toxic action(s) that offset its neuroprotective ability.
Epidemiological studies conducted during the past decade
revealed that CD is one of the most common lifelong disorders worldwide. CD can
manifest with a previously unsuspected range of clinical presentations, including the
typical malabsorption syndrome and a spectrum of symptoms potentially affecting
any organ system. Since CD is often atypical or even silent on clinical ground, many
cases remain undiagnosed and exposed to the risk of long term complications, such as
anemia and other hematological complications, osteoporosis, neurological
complications or cancer....
Sonneville et al. Annals of Intensive Care 2011, 1:10 http://www.annalsofintensivecare.com/content/1/1/10
Management of neurological complications of infective endocarditis in ICU patients
Romain Sonneville, Bruno Mourvillier, Lila Bouadma and Michel Wolff*
Abstract Patients with infective endocarditis (IE) are generally referred to the intensive care unit (ICU) for one or more organ dysfunctions caused by complications of IE. Neurologic events are frequent causes of ICU admission in patients with IE.
Paraneoplastic neurologic disorders (PNDs) are cancer-related syndromes that can affect any part of the nervous system (Table 97-1). They are remote effects of cancer, caused by mechanisms other than metastasis or by any of the complications of cancer such as coagulopathy, stroke, metabolic and nutritional conditions, infections, and side effects of cancer therapy. In 60% of patients the neurologic symptoms precede the cancer diagnosis. Overall, clinically disabling PNDs occur in 0.
Corticosteroids are often used as an adjunct in the treatment of various forms of tuberculosis (TB) and for the prevention
of complications, such as constrictive pericarditis, hydrocephalus, focal neurological deficits, pleural adhesions, and intestinal
strictures. Notwithstanding, they have been proven in clinical trials to improve the following outcomes only — death or
disability in human immunodeficiency virus (HIV)-seronegative patients with tubercular meningitis and tubercular
Figure 12 Diabetic neuroarthropathy, or Charcot foot, is believed to be a neurologically-mediated complication of diabetes, with the development modified by musculoskeletal stress. The result is osseous fragmentation and joint subluxation with often significant morphologic changes in the architecture of the foot. Complications of the Charcot foot include ulceration under areas of bony prominence and potential amputation often related to infection/osteomyelitis that develops adjacent to the area of ulceration.
Epilepsy is the most common neurological
disorder in adolescence. The convulsive disorders
may conveniently be divided into epilepsy
beginning before adolescence and epilepsy arising
during adolescence. Juvenile myoclonic epilepsy
typically begins in early adolescence with a peak
of onset between 13 and 15 years of age. Primary
generalized epilepsy namely the juvenile absence
epilepsy is an age-related onset usually at puberty
is a distinct syndrome from childhood absence
As part of our clinical and research activities in neurology and psychiatry,
we had the chance to examine hundreds of patients with Parkinson’s disease
(PD). The Movement Disorders Unit kept us abreast of the new developments
in the management of the clinical complications of PD, and made us
aware of the emotional, behavioral, and cognitive complications of the
disease. These problems have been speciWcally studied at the Departments
of Neuropsychiatry of our Institutes, where we carry out most of our clinical
and research activities in the interface between neurology and psychiatry....