Diseases of the neuromuscular junction (NMJ) include a large spectrum of
acquired and inherited disorders mainly characterized by fluctuating muscle
weakness and fatigability of ocular, bulbar or limb muscles. Remarkable
progress has been made in our understanding of the pathogenesis of these
disorders in recent years.
Pompilidotoxins (PMTXs,a and b) are small peptides consisting of 13
amino acids purified from the venom of the solitary waspsAnoplius samari-ensis(a-PMTX) and Batozonellus maculifrons(b-PMTX). They are known
to facilitate synaptic transmission in the lobster neuromuscular junction,
and to slow sodium channel inactivation.