This book is about how to construct and use computational models of specific
parts of the nervous system, such as a neuron, a part of a neuron or a
network of neurons. It is designed to be read by people from a wide range of
backgrounds from the biological, physical and computational sciences. The
word ‘model’ can mean different things in different disciplines, and even researchers
in the same field may disagree on the nuances of its meaning.
NADPH-dependent dual-flavin enzymes provide electrons in many redox
reactions, although the mechanism responsible for regulating their electron
flux remains unclear. We recently proposed a four-state kinetic model that
links the electron flux through a dual-flavin enzyme to its rates of interfla
In view of the dynamic growth in the luxury market and the availability of luxury goods to a wider range of consumers
than ever before, the luxury market has transformed from its traditional conspicuous consumption model to a new
experiential luxury sensibility marked by a change in the way consumers define luxury. In a global context, it is critically
important for luxury researchers and marketers to understand why consumers buy luxury, what they believe luxury is and
how their perception of luxury value impacts their buying behavior.
Abstract Although gait change is considered a useful indicator of severity in animal models of Parkinson's disease, systematic and extensive gait analysis in animal models of neurological deficits is not well established. The CatWalk-assisted automated gait analysis system provides a comprehensive way to assess a number of dynamic and static gait parameters simultaneously. In this study, we used the Catwalk system to investigate changes in gait parameters in adult rats with unilateral 6-OHDA-induced lesions and the...
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Selective COX-2 inhibition prevents progressive dopamine neuron degeneration in a rat model of Parkinson's disease
Recent re-analyses of time series studies have highlighted a second important epidemiological
and statistical issue known as confounding bias. Pollution relative rate estimates for mortality=
morbidity could be confounded by observed and unobserved time-varying confounders (such as
weather variables, season, and in°uenza epidemics) that vary in a similar manner as the air pol-
lution and mortality=morbidity time series. To control for confounding bias, smooth functions of
time and temperature variables are included into the semi-parametric Poisson regression model....
A large body of research over several decades has grappled with how and
whether fear can persuade consumers to change their health behaviors. Different
models have been proposed to describe the cognitive and emotional
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Modified cell cycle status in a mouse model of altered neuronal vulnerability (slow Wallerian degeneration; Wlds)...
It is our pleasure to present the Proceedings of the 16th
International Congress on Parkinson’s Disease (PD) and
Related Disorders (16th ICPD) which took place in Berlin
from June 5–9, 2005. This congress was the most successful
congress ever with more than 3500 participants in the
roaring German capital, consisting of an innovative program
and with emphasis on bringing basic and clinical scientists
together. Special attention has was paid in inviting young
The extracellular signal regulated protein kinases (ERK1/2)
are essential for normal development and functional plasti-city of the central nervous system. However, a growing
number of recent studies in models of cerebral ischemia,
brain trauma and neurodegenerative diseases implicate a
detrimental role for ERK1/2 signaling during oxidative
neuronal injury. Neurons undergoing oxidative stress-rela-ted injuries typically display a biphasic or sustained pattern
of ERK1/2 activation.
Recent and increasing use of computational tools in the field
of nicotinic receptors has led to the publication of several
models of ligand–receptor interactions. Thesemodels are all
basedon the crystal structure at 2.7 A˚ resolutionof aprotein
related to the extracellular N-terminus of nicotinic acetyl-choline receptors (nAChRs), the acetylcholine binding pro-tein. In the absence of any X-ray or NMR information on
nAChRs, this new structure has provided a reliable alter-native to study the nAChR structure....
Meta-theoretical results on the decidability, generatire capacity, and recognition complexity o~ several syntactic theories are surveyed These include context-free , lexical func-computer o r a parallel array of neurons. These results over whole classes of machines are very difficult to obtain, and none el any significance exist for parsiD.g problems. Restricting ourselves to a specific machine model and an algorithm M for j', we can ask about the cost. (e.g time or space) e(z) of executing M on a specific input z. ...
At the time of Isaac Newton’s invention of the calculus in the 17th century, the mechanical clock was the most
sophisticated machine known. The simplicity of the clock allowed its movements to be completely described with
mathematics. Newton not only described the clock’s movements with mathematics, but also the movements of the
planets and other astronomical bodies. Because of the success of the Newtonian method, a mathematics-based
model of reality resulted.
The purpose of
The Handbook of Neuroprosthetic Methods
is threefold. First,
the book combines the most commonly employed concepts, applications,
and knowledge from the many disciplines associated with neuroprosthetic
research in a clear and instructive way. Second, the book provides examples
of neuroprosthetic systems at different stages of development, from the more
mature cochlear implant to the maturing areas of upper-limb and motor
control to the relatively fledgling area of visual prostheses.
Motor neuron degeneration in amyotrophic lateral sclerosis involves oxida-tive damage. Glutathione (GSH) is critical as an antioxidant and a redox
modulator. We used a motor neuronal cell line (NSC-34) to investigate
whether wild-type and familial amyotrophic lateral sclerosis-linked G93A
mutant Cu,Zn superoxide dismutase (wt⁄G93ASOD1) modified the GSH
pool and glutamate cysteine ligase (GCL), the rate-limiting enzyme for
An emerging body of evidence supports a key role for the endocannabinoid
system in numerous physiological and pathological mechanisms of the cen-tral nervous system. In the recent past, many experimental studies have
examined the putative protective or toxic effects of drugs interacting with
cannabinoid receptors or have measured the brain levels of endocannabi-noids inin vitro and in vivo models of cerebral ischemia.
Parkinson’s disease (PD), a common progressive neurodegenerative disor-der, is characterized by degeneration of dopamine neurons in the substantia
nigra and neuronal proteinaceous aggregates called Lewy bodies (LBs).
The etiology of PD is probably a combination of environmental and
(BQ) Part 1 book "Molecular histopathology and tissue biomarkers in drug and diagnostic development" presentation of content: Histopathology - A canvas and landscape of disease in drug and diagnostic development, histopathology in mouse models of rheumatoid arthritis, markers used for visualization and quantification of blood and lymphatic vessels, image analysis tools for quantification of spinal motor neuron subtype identities,...
Chapter 1: Your Neurons at Work Chapter 2: Framing Your Thoughts Chapter 3: Putting Your Brain to Work Chapter 4: Tools for Clear Thinking Chapter 5: Food for Thought Chapter 6: The Conscious Mind Chapter 7: A Model of the Mind Chapter 8: Solving Problems Chapter 9: Getting it Right Chapter 10: Managing Your Resources Chapter 11: Clear Thinking and